Intracellular pH sensors: design principles and functional significance (Q36731993)

15 August 2017

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title

Intracellular pH sensors: design principles and functional significance (English)

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15 August 2017

3

Matthew P Jacobson

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15 August 2017

2

Diane L Barber

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15 August 2017

1

Jyoti Srivastava

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PubMed ID

17289928

15 August 2017

language of work or name

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1 February 2007

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15 August 2017

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15 August 2017

22

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15 August 2017

30-39

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Imaging alpha-hemolysin with molecular dynamics: ionic conductance, osmotic permeability, and the electrostatic potential map

15 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Incorporating protein conformational flexibility into the calculation of pH-dependent protein properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The determinants of pKas in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Structural and dynamical properties of different protonated states of mutant HIV-1 protease complexed with the saquinavir inhibitor studied by molecular dynamics simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

pH regulates the polymerization of actin in the sea urchin egg cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The LDL receptor: how acid pulls the trigger

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Atomic resolution structures of ribonuclease A at six pH values

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Intracellular pH modulation of ADF/cofilin proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Calculations of proton-binding thermodynamics in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Regulation of intracellular pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

A comparative structural analysis of the ADF/cofilin family

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Structural definition of the F-actin-binding THATCH domain from HIP1R

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Structure of influenza haemagglutinin at the pH of membrane fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Histidine button engineered into cardiac troponin I protects the ischemic and failing heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Molecular mechanisms of pH-driven conformational transitions of proteins: insights from continuum electrostatics calculations of acid unfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Calpain-mediated proteolysis of talin regulates adhesion dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Combining conformational flexibility and continuum electrostatics for calculating pK(a)s in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Functional plasticity in the substrate binding site of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: contribution of His41 to the pH-dependent stability of the N-terminal subdomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Conformational changes in cubic insulin crystals in the pH range 7-11

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Human immunodeficiency virus-1 protease. 2. Use of pH rate studies and solvent kinetic isotope effects to elucidate details of chemical mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

How pH opens a H+ channel: the gating mechanism of influenza A M2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Constant pH molecular dynamics with proton tautomerism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Polarization of Na(+)/H(+) and Cl(-)/HCO (3)(-) exchangers in migrating renal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Alterations of intracellular pH homeostasis in apoptosis: origins and roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The structure--function relationship of hemoglobin in solution at atomic resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The effect of two actin depolymerizing factors (ADF/cofilins) on actin filament turnover : pH sensitivity of F-actin binding by human ADF, but not of Acanthamoeba actophorin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Ca2+ activation of the cPLA2 C2 domain: ordered binding of two Ca2+ ions with positive cooperativity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Atomic description of an enzyme reaction dominated by proton tunneling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The I/LWEQ module: a conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Acid-triggered membrane insertion of Pseudomonas exotoxin A involves an original mechanism based on pH-regulated tryptophan exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Raman spectroscopic study on the copper(II) binding mode of prion octapeptide and its pH dependence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Biomolecular simulations at constant pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Constant pH molecular dynamics in generalized Born implicit solvent

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The pH dependence of stability of the activation helix and the catalytic site of GART.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Twinfilin is an actin-filament-severing protein and promotes rapid turnover of actin structures in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The Molecular Basis for the pH-activation Mechanism in the Channel-forming Bacterial Colicin E1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The closed state of a H+ channel helical bundle combining precise orientational and distance restraints from solid state NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Protonation of histidine and histidine-tryptophan interaction in the activation of the M2 ion channel from influenza a virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

A Novel View of pH Titration in Biomolecules†

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Structural basis of the Tanford transition of bovine beta-lactoglobulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Effect of inhibitors of Na+/H+-exchange and gastric H+/K+ ATPase on cell volume, intracellular pH and migration of human polymorphonuclear leucocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Molecular basis of listeriolysin O pH dependence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Gating of inward-rectifier K+ channels by intracellular pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Optimization of 13C direct detection NMR methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Electrostatic coupling to pH-titrating sites as a source of cooperativity in protein-ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Role of the Na/H exchanger NHE1 in cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Towards a structural view of gating in potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Multistate folding of the villin headpiece domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Polymerization of actin. IV. Role of Ca++ and H+ in the assembly of actin and in membrane fusion in the acrosomal reaction of echinoderm sperm

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Structural mechanism of plant aquaporin gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Cytosolic pH regulates root water transport during anoxic stress through gating of aquaporins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The role of intracellular alkalinization in the establishment of anterior neural fate in Xenopus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Regulation of movement speed by intracellular pH during Dictyostelium discoideum chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Improving the accuracy of protein pKa calculations: conformational averaging versus the average structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

NMR structure of an F-actin-binding "headpiece" motif from villin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Structural basis of pH-dependent antibody binding by the neonatal Fc receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The Na+/H+ antiporter potentiates growth and retinoic acid-induced differentiation of P19 embryonal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Improved pKa calculations through flexibility based sampling of a water-dominated interaction scheme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Calpain proteases in cell adhesion and motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Local conformational fluctuations can modulate the coupling between proton binding and global structural transitions in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Crystal structures of CO-, deoxy- and met-myoglobins at various pH values

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Conformation and hydrogen ion titration of proteins: a continuum electrostatic model with conformational flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Modulation of endothelial cell growth arrest and apoptosis by vascular endothelial growth inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

The Octapeptide Repeats in Mammalian Prion Protein Constitute a pH-dependent Folding and Aggregation Site

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Assessing the acid-base and conformational properties of histidine residues in human prion protein (125-228) by means of pKa calculations and molecular dynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

ADF/Cofilin Controls Cell Polarity during Fibroblast Migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Characterization of an Actin-binding Site within the Talin FERM Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

Modeling of protein conformational fluctuations in pKa predictions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00035.2006

10.1152/PHYSIOL.00035.2006

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

17289928