Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? (Q36736166)

16 August 2017

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title

Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? (English)

1 reference

16 August 2017

Abdullah Ozer

1

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PubMed ID

17301803

16 August 2017

Richard K Bruick

series ordinal

2

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16 August 2017

1 March 2007

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16 August 2017

Nature Chemical Biology

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16 August 2017

3

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16 August 2017

3

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16 August 2017

144-153

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https://scigraph.springernature.com/pub.10.1038/nchembio863

16 August 2017

0 references

cites work

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21 January 2018

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Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

21 January 2018

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Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis

21 January 2018

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Enzymatic hydroxylation of proline and lysine in protocollagen

21 January 2018

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

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Hydroxylation of aspartic acid in domains homologous to the epidermal growth factor precursor is catalyzed by a 2-oxoglutarate-dependent dioxygenase

21 January 2018

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Alternative reactivity of an alpha-ketoglutarate-dependent iron(II) oxygenase: enzyme self-hydroxylation

21 January 2018

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Targeting HIF-1 for cancer therapy

21 January 2018

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Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

21 January 2018

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Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor

21 January 2018

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Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

21 January 2018

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 January 2018

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

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Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

21 January 2018

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

21 January 2018

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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

21 January 2018

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

21 January 2018

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A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

21 January 2018

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO863

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

21 January 2018

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Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

21 January 2018

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Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau

21 January 2018

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Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

21 January 2018

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Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Binding of natively unfolded HIF-1alpha ODD domain to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Endogenous 2-oxoacids differentially regulate expression of oxygen sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

The language of covalent histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Histone acetylation in chromatin structure and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Reversing histone methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Histone methylation: dynamic or static?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Methylation: lost in hydroxylation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

JmjC-domain-containing proteins and histone demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Histone demethylation by a family of JmjC domain-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Structural insights into histone demethylation by JMJD2 family members.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Regulation of p53 activity through lysine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Gene-specific modulation of TAF10 function by SET9-mediated methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Cytochrome c methyltransferase, Ctm1p, of yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Methylation of Smad6 by protein arginine N-methyltransferase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Histone deimination antagonizes arginine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

The Skp1 prolyl hydroxylase from Dictyostelium is related to the hypoxia-inducible factor-alpha class of animal prolyl 4-hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Oxygen and iron regulation of iron regulatory protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

The role of iron regulatory proteins in mammalian iron homeostasis and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Mechanism of the Prolyl Hydroxylase Reaction. 2. Kinetic Analysis of the Reaction Sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

Collagen structure: the Madras triple helix and the current scenario

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Methylation of DNA polymerase beta by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO863

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO863

1 reference

16 August 2017

1 reference

PubMed ID

17301803