PI3-kinase mutation linked to insulin and growth factor resistance in vivo (Q36737908)

16 August 2017

PI3-kinase mutation linked to insulin and growth factor resistance in vivo (English)

1 reference

16 August 2017

12

Pål R Njølstad

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16 August 2017

10

Anders Molven

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16 August 2017

11

C Ronald Kahn

1 reference

16 August 2017

Jonathon N Winnay

1

1 reference

16 August 2017

Marie H Solheim

2

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16 August 2017

Ercument Dirice

3

1 reference

16 August 2017

Masaji Sakaguchi

4

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16 August 2017

Hye-Lim Noh

5

1 reference

16 August 2017

Hee Joon Kang

6

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16 August 2017

Hirokazu Takahashi

7

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16 August 2017

Kishan K Chudasama

8

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16 August 2017

Jason K Kim

9

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16 August 2017

language of work or name

English

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publication date

14 March 2016

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Journal of Clinical Investigation

16 August 2017

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16 August 2017

126

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16 August 2017

4

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16 August 2017

1401-1412

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describes a project that uses

16 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4811129/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Exome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndrome

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A novel deletion of IGF1 in a patient with idiopathic short stature provides insight Into IGF1 haploinsufficiency.

29 September 2017

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Mutations in PIK3R1 cause SHORT syndrome

29 September 2017

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SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling

29 September 2017

1 reference

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PIK3R1 mutations cause syndromic insulin resistance with lipoatrophy

29 September 2017

1 reference

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Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in mice

29 September 2017

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Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms

29 September 2017

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A heterozygous mutation of the insulin-like growth factor-I receptor causes retention of the nascent protein in the endoplasmic reticulum and results in intrauterine and postnatal growth retardation

29 September 2017

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A-type lamins and signaling: the PI 3-kinase/Akt pathway moves forward

29 September 2017

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Lamin A Ser404 is a nuclear target of Akt phosphorylation in C2C12 cells

29 September 2017

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

29 September 2017

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The Rap-B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells

29 September 2017

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A family with severe insulin resistance and diabetes due to a mutation in AKT2.

29 September 2017

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p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity

29 September 2017

1 reference

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Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

29 September 2017

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Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

29 September 2017

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Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

29 September 2017

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Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

29 September 2017

1 reference

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Integrative mitogenic role of protein kinase B/Akt in beta-cells.

29 September 2017

1 reference

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Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit

29 September 2017

1 reference

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Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein

29 September 2017

1 reference

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Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

29 September 2017

1 reference

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Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice

29 September 2017

1 reference

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

29 September 2017

1 reference

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Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin

29 September 2017

1 reference

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The study of phosphoinositide 3-kinase function

29 September 2017

1 reference

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Role of insulin-like growth factors in embryonic and postnatal growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

SHORT syndrome and insulin resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

The SHORT syndrome: further delineation and natural history

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Insulin Receptor Deficiency in Genetic and Acquired Obesity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Heterozygous mutation within a kinase-conserved motif of the insulin-like growth factor I receptor causes intrauterine and postnatal growth retardation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Insulin Receptor Regulation and Desensitization in Rat Hepatoma Cells: Concomitant Changes in Receptor Number and in Binding Affinity

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

PIK3R1 mutations in SHORT syndrome

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Hyperinsulinemic-euglycemic clamp to assess insulin sensitivity in vivo.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Identification by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and phosphatidylinositol 3-kinase

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811129

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

4 December 2018

1 reference

12 December 2020

Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance

1 reference

12 December 2020

Autosomal dominant partial lipodystrophy associated with Rieger anomaly, short stature, and insulinopenic diabetes

1 reference

12 December 2020

SHORT syndrome: a new case with probable autosomal dominant inheritance.

1 reference

12 December 2020

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess

1 reference

12 December 2020

Identification of a novel heterozygous IGF1 splicing mutation in a large kindred with familial short stature

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI84005

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

26974159

1 reference