Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes (Q28344700)

10

object named as

C Ronald Kahn

0 references

Kohjiro Ueki

2

object named as

Kohjiro Ueki

0 references

Matteo Iannacone

object named as

Matteo Iannacone

7

1 reference

ORCID Public Data File 2021

author name string

Franck Mauvais-Jarvis

1

0 references

David A Fruman

3

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Michael F Hirshman

4

0 references

Kei Sakamoto

5

0 references

Laurie J Goodyear

6

0 references

Lewis C Cantley

Journal of Clinical Investigation

9

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language of work or name

English

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publication date

January 2002

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published in

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volume

109

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page(s)

141-9

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issue

1

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cites work

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20 March 2017

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1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

20 March 2017

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Positional cloning of the mouse obese gene and its human homologue

20 March 2017

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The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

20 March 2017

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Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

20 March 2017

1 reference

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A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene

20 March 2017

1 reference

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Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

20 March 2017

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Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit

29 September 2017

1 reference

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Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy

29 September 2017

1 reference

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Insulin action in the polycystic ovary syndrome

29 September 2017

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Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

29 September 2017

1 reference

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The role of phosphoinositide 3-kinase lipid products in cell function

29 September 2017

1 reference

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Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains

29 September 2017

1 reference

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Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phosphoenolpyruvate carboxykinase gene transcription

29 September 2017

1 reference

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Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

29 September 2017

1 reference

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p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin

29 September 2017

1 reference

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Specific increase in p85alpha expression in response to dexamethasone is associated with inhibition of insulin-like growth factor-I stimulated phosphatidylinositol 3-kinase activity in cultured muscle cells

29 September 2017

1 reference

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Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.

29 September 2017

1 reference

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Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene

29 September 2017

1 reference

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Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

29 September 2017

1 reference

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Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

29 September 2017

1 reference

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Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150818

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150818

Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150818

Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway

2 June 2018

1 reference

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Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150818

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150818

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150818

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150818

Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150818

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

27 November 2018

1 reference

12 December 2020

Signalling pathways involved in the stimulation of glycogen synthesis by insulin in rat hepatocytes

1 reference

12 December 2020

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

1 reference

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

12 December 2020

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

1 reference

12 December 2020

The missing link with obesity?

1 reference

12 December 2020

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

1 reference

12 December 2020

Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin

1 reference

12 December 2020

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2882825

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release_y4ao5kymxrchhbp4xfsn2tzy7e

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2882825

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1 reference

1 reference