Sonic hedgehog signalling in T-cell development and activation (Q36906677)

17 August 2017

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title

Sonic hedgehog signalling in T-cell development and activation (English)

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17 August 2017

Tessa Crompton

1

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PubMed ID

17690714

17 August 2017

Susan V Outram

series ordinal

2

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PubMed ID

17690714

17 August 2017

Ariadne L Hager-Theodorides

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3

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17 August 2017

10 August 2007

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Nature Reviews Immunology

17 August 2017

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17 August 2017

7

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17 August 2017

9

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17 August 2017

726-735

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Notch regulation of lymphocyte development and function.

17 August 2017

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

31 March 2020

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Synergy between the pre-T cell receptor and Notch: cementing the alphabeta lineage choice

31 March 2020

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An HMG-box-containing T-cell factor required for thymocyte differentiation.

31 March 2020

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Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

31 March 2020

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Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development

31 March 2020

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BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis.

31 March 2020

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The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development

31 March 2020

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The role of morphogens in T-cell development

31 March 2020

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Orchestrating ontogenesis: variations on a theme by sonic hedgehog

31 March 2020

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Hedgehog signaling in animal development: paradigms and principles

31 March 2020

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Decoding the Hedgehog signal in animal development.

31 March 2020

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Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

31 March 2020

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The Hedgehog and Wnt signalling pathways in cancer

31 March 2020

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Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte

31 March 2020

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The specification of neuronal identity by graded Sonic Hedgehog signalling.

31 March 2020

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Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity

31 March 2020

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The Hedgehog response network: sensors, switches, and routers

31 March 2020

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Gli-type zinc finger proteins as bipotential transducers of Hedgehog signaling

31 March 2020

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Gli genes in development and cancer

31 March 2020

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Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

31 March 2020

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Eyes absent, a key repressor of polar cell fate during Drosophila oogenesis

31 March 2020

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Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

31 March 2020

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A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

31 March 2020

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The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

31 March 2020

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The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

31 March 2020

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The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3- cells, as well as macrophages

31 March 2020

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T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver.

31 March 2020

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Control points in early T-cell development

31 March 2020

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A positive look at double-negative thymocytes

31 March 2020

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On the brink of becoming a T cell.

31 March 2020

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Regulation of thymocyte differentiation: pre-TCR signals and beta-selection

31 March 2020

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Trafficking on serpentines: molecular insight on how maturating T cells find their winding paths in the thymus.

31 March 2020

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Thymic T cell development and progenitor localization depend on CCR7.

31 March 2020

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Role of thymic organ structure and stromal composition in steady-state postnatal T-cell production

31 March 2020

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Precursor thymocyte proliferation and differentiation are controlled by signals unrelated to the pre-TCR

31 March 2020

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Shaping the T cell repertoire

31 March 2020

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Negative selection of the T-cell repertoire: where and when does it occur?

31 March 2020

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T-cell development and the CD4-CD8 lineage decision

31 March 2020

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CD4-CD8 lineage commitment: an inside view

31 March 2020

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Thymic microenvironments for T cell differentiation and selection.

31 March 2020

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Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus

31 March 2020

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Zoned out: functional mapping of stromal signaling microenvironments in the thymus

31 March 2020

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Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation

31 March 2020

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Studies on the phenotype of migrant thymic stem cells

31 March 2020

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Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development

31 March 2020

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Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development.

31 March 2020

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Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization.

31 March 2020

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Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus.

31 March 2020

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Progression of regulatory gene expression states in fetal and adult pro-T-cell development

31 March 2020

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Reduced thymocyte development in sonic hedgehog knockout embryos

31 March 2020

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Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation

31 March 2020

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The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.

31 March 2020

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A novel approach to thymic rejuvenation in the aged

31 March 2020

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Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus

31 March 2020

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Expression of hedgehog proteins in the human thymus

31 March 2020

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Estrogen deficiency results in enhanced expression of Smoothened of the Hedgehog signaling in the thymus and affects thymocyte development

31 March 2020

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Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

31 March 2020

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Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.

31 March 2020

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Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling

31 March 2020

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The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity

31 March 2020

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Sonic hedgehog regulates early human thymocyte differentiation by counteracting the IL-7-induced development of CD34+ precursor cells

31 March 2020

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Inhibition of GLI1 gene activation by Patched1

31 March 2020

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The interpretation of morphogen gradients

31 March 2020

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Immature thymocytes that fail to express TCRbeta and/or TCRgamma delta proteins die by apoptotic cell death in the CD44(-)CD25(-) (DN4) subset.

31 March 2020

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

31 March 2020

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

31 March 2020

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RAG-1-deficient mice have no mature B and T lymphocytes

31 March 2020

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Fine tuning of TCR signaling by CD5.

31 March 2020

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Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis.

31 March 2020

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Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes

31 March 2020

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Sonic hedgehog promotes cell cycle progression in activated peripheral CD4(+) T lymphocytes

31 March 2020

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Sonic Hedgehog Signaling Modulates Activation of and Cytokine Production by Human Peripheral CD4+ T Cells

31 March 2020

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Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia

31 March 2020

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Regulation of lymphoid development, differentiation, and function by the Notch pathway.

31 March 2020

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Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling

31 March 2020

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Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

31 March 2020

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Levels of Gli3 repressor correlate with Bmp4 expression and apoptosis during limb development.

31 March 2020

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A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon.

31 March 2020

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Mutations affecting segment number and polarity in Drosophila

31 March 2020

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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

31 March 2020

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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

31 March 2020

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Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

31 March 2020

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Embryonic origins of mammalian hematopoiesis

31 March 2020

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Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration

31 March 2020

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Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

31 March 2020

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Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

31 March 2020

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An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis

31 March 2020

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Gli and hedgehog in cancer: tumours, embryos and stem cells.

31 March 2020

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Hedgehog signalling in cancer formation and maintenance

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2151

1 reference

17 August 2017

1 reference

PubMed ID

17690714