Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design (Q36908436)

17 August 2017

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title

Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design (English)

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17 August 2017

Hodawadekar SC

1

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17 August 2017

Marmorstein R

series ordinal

2

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17 August 2017

language of work or name

English

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publication date

1 August 2007

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17 August 2017

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17 August 2017

volume

26

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17 August 2017

issue

37

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17 August 2017

page(s)

5528-5540

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Neuronal protection by sirtuins in Alzheimer's disease

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structural basis for the mechanism and regulation of Sir2 enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Resveratrol improves health and survival of mice on a high-calorie diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Catalytic mechanism of a MYST family histone acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Epigenetics--an epicenter of gene regulation: histones and histone-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Anticancer activities of histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Mechanism of human SIRT1 activation by resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

MOZ is fused to p300 in an acute monocytic leukemia with t(8;22).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Histone deacetylases (HDACs): characterization of the classical HDAC family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Conjunction dysfunction: CBP/p300 in human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Acetylation and deacetylation of non-histone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Sir2: an NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Substrate-specific activation of sirtuins by resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Histone deacetylase inhibitors: from target to clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Use of substrate analogs and mutagenesis to study substrate binding and catalysis in the Sir2 family of NAD-dependent protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Targeting histone deacetylase in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Histone chaperones, a supporting role in the limelight

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Crystal structure of the nucleosome core particle at 2.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Histone deacetylase inhibitors in programmed cell death and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structure and function of histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structure of histone deacetylases: insights into substrate recognition and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Histone acetyltransferases: function, structure, and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Linking histone acetylation to transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

An active site tyrosine residue is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Crystal structure of a bacterial class 2 histone deacetylase homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Histone modifications: signalling receptors and potential elements of a heritable epigenetic code

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Inhibitors of Sir2: evaluation of splitomicin analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

The biochemistry of sirtuins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Acetylation of histones and transcription-related factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Regulation of the p300 HAT domain via a novel activation loop.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Histone acetylation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Regulation of higher-order chromatin structures by nucleosome-remodelling factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Implications of small molecule activators and inhibitors of histone acetyltransferases in chromatin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

21 January 2018

Chromatin architecture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Histone modifying enzymes and cancer: going beyond histones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

DFT-based ranking of zinc-binding groups in histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD+ and Acetylated Peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

Insights into structure and function of GCN5/PCAF and yEsa 1 histone acetyltransferase domains:

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

7 January 2021

HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

7 January 2021

N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

7 January 2021

p300/CBP-associated factor histone acetyltransferase processing of a peptide substrate. Kinetic analysis of the catalytic mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

7 January 2021

Innovative agents in cancer prevention.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

7 January 2021

Hat1: the emerging cellular roles of a type B histone acetyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

7 January 2021

Sirtuins: critical regulators at the crossroads between cancer and aging

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

7 January 2021

Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210619

7 January 2021

Theoretical study revealing the functioning of a novel combination of catalytic motifs in histone deacetylase

1 reference

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7 January 2021

Selective HAT inhibitors as mechanistic tools for protein acetylation

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210619

1 reference

17 August 2017

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