Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR. (Q36910210)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23620596%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR (English)

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29 February 2020

2

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29 February 2020

author name string

D Fernando Estrada

series ordinal

1

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29 February 2020

Emily E Scott

series ordinal

3

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29 February 2020

language of work or name

English

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publication date

25 April 2013

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29 February 2020

number of pages

11

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Journal of Biological Chemistry

inferred from page(s)

published in

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29 February 2020

volume

288

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issue

23

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29 February 2020

page(s)

17008-17018

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The action of cytochrome b(5) on CYP2E1 and CYP2C19 activities requires anionic residues D58 and D65.

29 February 2020

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Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5).

29 September 2017

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Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

29 September 2017

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The syndrome of 17,20 lyase deficiency

29 September 2017

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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

29 September 2017

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Abiraterone and increased survival in metastatic prostate cancer

29 September 2017

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29 September 2017

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The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b(5).

29 September 2017

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Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven.

29 September 2017

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The developmental increase in adrenocortical 17,20-lyase activity (biochemical adrenarche) is driven primarily by increasing cytochrome b5 in neonatal rhesus macaques.

29 September 2017

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Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven.

29 September 2017

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Identification of the interactions between cytochrome P450 2E1 and cytochrome b5 by mass spectrometry and site-directed mutagenesis

29 September 2017

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Human cytochrome b5 requires residues E48 and E49 to stimulate the 17,20-lyase activity of cytochrome P450c17.

29 September 2017

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Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis

29 September 2017

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Using NMRView to visualize and analyze the NMR spectra of macromolecules

29 September 2017

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Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer

29 September 2017

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CYP17 Mutation E305G Causes Isolated 17,20-Lyase Deficiency by Selectively Altering Substrate Binding

29 September 2017

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The many roles of cytochrome b5

29 September 2017

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The molecular basis of isolated 17,20 lyase deficiency

29 September 2017

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Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer

29 September 2017

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Solution structure of reduced microsomal rat cytochrome b5

29 September 2017

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The genetic and functional basis of isolated 17,20-lyase deficiency

29 September 2017

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

29 September 2017

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Male pseudohermaphroditism due to 17α-hydroxylase deficiency

29 September 2017

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Cytochrome P-450 C21scc: one enzyme with two actions: hydroxylase and lyase

29 September 2017

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Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis

29 September 2017

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Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase.

29 September 2017

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Interaction of human CYP17 (P-450(17alpha), 17alpha-hydroxylase-17,20-lyase) with cytochrome b5: importance of the orientation of the hydrophobic domain of cytochrome b5.

27 June 2018

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Modeling and mutagenesis of the active site of human P450c17.

27 June 2018

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The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.

27 June 2018

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Expression of cytochrome b5 in yeast and characterization of mutants of the membrane-anchoring domain.

27 June 2018

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Effect of polymorphism in the porcine cytochrome b5 ( CYB5A) gene on androstenone and skatole concentrations and sexual development in Swedish pig populations

27 June 2018

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NMR structure note: oxidized microsomal human cytochrome b5.

4 September 2018

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Engineering, expression, and purification of "soluble" human cytochrome P45017alpha and its functional characterization

4 September 2018

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The cationic charges on Arg347, Arg358 and Arg449 of human cytochrome P450c17 (CYP17) are essential for the enzyme's cytochrome b5-dependent acyl-carbon cleavage activities

4 September 2018

1 reference

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The alpha-helical membrane spanning domain of cytochrome b5 interacts with cytochrome P450 via nonspecific interactions

4 September 2018

1 reference

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Refinement and structural analysis of bovine cytochrome b5 at 1.5 A resolution

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675632

Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675632

Reconstitution of the enzymatic activities of cytochrome P450s using recombinant flavocytochromes containing rat cytochrome b(5) fused to NADPH--cytochrome P450 reductase with various membrane-binding segments

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675632

Lysine mutagenesis identifies cationic charges of human CYP17 that interact with cytochrome b5 to promote male sex-hormone biosynthesis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675632

P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675632

Cytochrome b5 increases the rate of product formation by cytochrome P450 2B4 and competes with cytochrome P450 reductase for a binding site on cytochrome P450 2B4

4 September 2018

1 reference

12 December 2020

Effects of conditions for reconstitution with cytochrome b5 on the formation of products in cytochrome P-450-catalyzed reactions

1 reference

12 December 2020

Role of electron transport in the regulation of the lyase activity of C21 side-chain cleavage P-450 from porcine adrenal and testicular microsomes

1 reference

12 December 2020

Cytochrome b5 inhibits electron transfer from NADPH-cytochrome P450 reductase to ferric cytochrome P450 2B4

1 reference

12 December 2020

Influence of ionic strength on the P450 monooxygenase reaction and role of cytochrome b5 in the process

1 reference

12 December 2020

Abnormal morphology of spermatozoa in cytochrome P450 17alpha-hydroxylase/17, 20-lyase (CYP17) deficient mice

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12 December 2020

Identifiers

DOI

10.1074/JBC.M113.468926

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23620596%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23620596%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

23620596

1 reference