Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1. (Q36917461)

17 August 2017

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title

Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1. (English)

1 reference

polycystic kidney disease

17 August 2017

0 references

1 reference

Thomas Weimbs

1

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17 August 2017

publication date

22 August 2007

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American Journal of Physiology - Renal Physiology

17 August 2017

published in

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17 August 2017

volume

293

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17 August 2017

issue

5

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17 August 2017

page(s)

F1423-32

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Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors

17 August 2017

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Understanding pathogenic mechanisms in polycystic kidney disease provides clues for therapy

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Signaling mechanisms, interaction partners, and target genes of STAT6.

21 January 2018

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Tuberous sclerosis and the kidney: from mesenchyme to epithelium, and beyond

21 January 2018

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Urinary clusterin levels in the rat correlate with the severity of tubular damage and may help to differentiate between glomerular and tubular injuries

21 January 2018

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An interleukin-4-induced transcription factor: IL-4 Stat

21 January 2018

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Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins

21 January 2018

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Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

21 January 2018

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Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia

21 January 2018

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21 January 2018

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21 January 2018

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The polycystic kidney disease 1 gene product modulates Wnt signaling

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Annexin A5 interacts with polycystin-1 and interferes with the polycystin-1 stimulated recruitment of E-cadherin into adherens junctions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

MAL regulates clathrin-mediated endocytosis at the apical surface of Madin-Darby canine kidney cells.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Sirolimus Prolongs Recovery from Delayed Graft Function After Cadaveric Renal Transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation

21 January 2018

1 reference

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Up-regulation of galectin-3 in acute renal failure of the rat

21 January 2018

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A possible role for metalloproteinases in renal cyst development

21 January 2018

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21 January 2018

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Tuberous sclerosis complex: from Drosophila to human disease.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.

21 January 2018

1 reference

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Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

C-type lectin-like domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Bending the MDCK cell primary cilium increases intracellular calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Removal of the MDCK cell primary cilium abolishes flow sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The renal cell primary cilium functions as a flow sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

PKD1 interacts with PKD2 through a probable coiled-coil domain

21 January 2018

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"Mistakes happen": somatic mutation and disease

21 January 2018

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Role of immunocompetent cells in nonimmune renal diseases

21 January 2018

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Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice

21 January 2018

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Renal cystic disease in tuberous sclerosis: role of the polycystic kidney disease 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystic kidney disease: cell division without a c(l)ue?

21 January 2018

1 reference

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Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Addition of sirolimus to cyclosporine delays the recovery from delayed graft function but does not affect 1-year graft function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-1 can interact with homer 1/Vesl-1 in postnatal hippocampal neurons

21 January 2018

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Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology.

21 January 2018

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Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD).

21 January 2018

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Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

21 January 2018

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Overexpression of PKD1 causes polycystic kidney disease

21 January 2018

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Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunities

21 January 2018

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Autosomal dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Xenopus Bicaudal-C is required for the differentiation of the amphibian pronephros.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Characterization of cis-autoproteolysis of polycystin-1, the product of human polycystic kidney disease 1 gene.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Regulation of mTOR by polycystin-1: is polycystic kidney disease a case of futile repair?

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Identification and expression of the mammalian homologue of Bicaudal-C

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The polycystin-1 C-type lectin domain binds carbohydrate in a calcium-dependent manner, and interacts with extracellular matrix proteins in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-1 interacts with intermediate filaments

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Role of primary cilia in the pathogenesis of polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Molecular pathogenesis of autosomal dominant polycystic kidney disease

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury

21 January 2018

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IL-13 activates STAT6 and inhibits liver injury induced by ischemia/reperfusion

21 January 2018

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T cells as mediators in renal ischemia/reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The C-terminal tail of the polycystin-1 protein interacts with the Na,K-ATPase alpha-subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Cystic kidney diseases: all roads lead to the cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

10.1152/AJPRENAL.00275.2007

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference