Maintaining immunological tolerance with Foxp3. (Q36965687)

17 August 2017

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title

Maintaining immunological tolerance with Foxp3. (English)

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17 August 2017

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Lauren E Mays

1

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17 August 2017

Youhai H Chen

series ordinal

2

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17 August 2017

language of work or name

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1 November 2007

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17 August 2017

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17 August 2017

volume

17

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17 August 2017

issue

11

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17 August 2017

page(s)

904-918

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https://scigraph.springernature.com/pub.10.1038/cr.2007.84

17 August 2017

exact match

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cites work

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

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https://api.crossref.org/works/10.1038%2FCR.2007.84

Peripheral selection of the T cell repertoire

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2007.84

Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2007.84

Selecting and maintaining a diverse T-cell repertoire

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2007.84

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2007.84

The immunopathology of multiple sclerosis: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Role of CD8+ T cells in murine experimental allergic encephalomyelitis

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2007.84

Multiple sclerosis: relevance of class I and class II MHC-expressing cells to lesion development

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2007.84

Functional diversity of helper T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

T(H)-17 cells in the circle of immunity and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Association of CD4+ CD25+ T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Regulatory T cells: key controllers of immunologic self-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2007.84

Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Guarding the immune system: suppression of autoimmunity by CD4+CD25+ immunoregulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

X-chromosome inactivation analysis in a female carrier of FOXP3 mutation

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2007.84

An essential role for Scurfin in CD4+CD25+ T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Mature T cells depend on signaling through the IKK complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

LAT-mediated signaling in CD4+CD25+ regulatory T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Essential role of LAT in T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Thymic development and peripheral homeostasis of regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Regulatory T cell development in the absence of functional Foxp3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Developmental regulation of Foxp3 expression during ontogeny.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Interleukin 2 signaling is required for CD4(+) regulatory T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

A function for interleukin 2 in Foxp3-expressing regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

FOXP3 controls regulatory T cell function through cooperation with NFAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Transcription factors of the NFAT family: regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Transcriptional regulation by calcium, calcineurin, and NFAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

NFAT signaling: choreographing the social lives of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Transcriptional mechanisms underlying lymphocyte tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Multiple Domains Define the Expression and Regulatory Properties of Foxp1 Forkhead Transcriptional Repressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

CD4+ CD25+ suppressor T cells: more questions than answers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Mechanisms of suppression by suppressor T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Human T regulatory cells can use the perforin pathway to cause autologous target cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Tolerance, not immunity, crucially depends on IL-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

T cell regulation as a side effect of homeostasis and competition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Dynamics of suppressor T cells: in vivo veritas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

In vivo instruction of suppressor commitment in naive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Regulatory T cells and mechanisms of immune system control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

Self-nonself discrimination by T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

A Molecular Basis for MHC Class II—Associated Autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4,

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis

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https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Control of autoimmune myocarditis and multiorgan inflammation by glucocorticoid-induced TNF receptor family-related protein(high), Foxp3-expressing CD25+ and CD25- regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Origin of regulatory T cells with known specificity for antigen

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Self-specific MHC class II-restricted CD4-CD8- T cells that escape deletion and lack regulatory activity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Interleukin-2 is indispensable for development of immunological self-tolerance

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion

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https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Fueling regulation: IL-2 keeps CD4+ Treg cells fit

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https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells

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https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

From vanilla to 28 flavors: multiple varieties of T regulatory cells

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https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice

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https://api.crossref.org/works/10.1038%2FCR.2007.84

7 January 2021

Identifiers

DOI

10.1038/CR.2007.84

1 reference

17 August 2017

1 reference