Transcriptional dysregulation during myeloid transformation in AML. (Q36970214)

17 August 2017

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title

Transcriptional dysregulation during myeloid transformation in AML. (English)

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transcriptional dysregulation

17 August 2017

main subject

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Pabst T

1

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17 August 2017

Mueller BU

series ordinal

2

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17 August 2017

language of work or name

English

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publication date

1 October 2007

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17 August 2017

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17 August 2017

volume

26

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17 August 2017

issue

47

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17 August 2017

page(s)

6829-6837

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210765

17 August 2017

exact match

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cites work

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Risk assessment in patients with acute myeloid leukemia and a normal karyotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPalpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Transcriptional regulation of granulocyte and monocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

c-Myc is a critical target for c/EBPalpha in granulopoiesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Reciprocal effects of C/EBPalpha and PKCdelta on JunB expression and monocytic differentiation depend upon the C/EBPalpha basic region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

C/EBPalpha and the pathophysiology of acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Regulation of CCAAT/enhancer-binding protein (C/EBP) activator proteins by heterodimerization with C/EBPgamma (Ig/EBP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Cis-acting regulatory variation in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Transcription factors in myeloid development: balancing differentiation with transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Transcriptional regulation in myelopoiesis: Hematopoietic fate choice, myeloid differentiation, and leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Phosphorylation of C/EBPalpha inhibits granulopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Disruption of differentiation in human cancer: AML shows the way.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Prognostically useful gene-expression profiles in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

C/EBPalpha directs monocytic commitment of primary myeloid progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Stepwise reprogramming of B cells into macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

Infrequent hypermethylation of CEBPA promotor in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: a report of 59 cases by the Groupe Français d'Hématologie Cellulaire (GFHC) and the Groupe Français de Cytogénétique Hématologique (GFCH)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

AML patients with CEBPalpha mutations mostly retain identical mutant patterns but frequently change in allelic distribution at relapse: a comparative analysis on paired diagnosis and relapse samples

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

Identification of RUNX1/AML1 as a classical tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

Mutation of CEBPA in familial acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling-based clustering of AML

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210765

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210765

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Dimensions Publication ID

17 August 2017

1050056036

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Fatcat ID

release_urzxrkrcg5chxmuxu5y3o7rvty

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Fatcat

https://api.fatcat.wiki/v0/release/urzxrkrcg5chxmuxu5y3o7rvty

24 November 2022

mapped directly with Wikidata item

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