Fatty acid synthase inhibitors: new directions for oncology (Q36985879)

17 August 2017

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title

Fatty acid synthase inhibitors: new directions for oncology (English)

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17 August 2017

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Steven J Kridel

1

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17 August 2017

W Todd Lowther

series ordinal

2

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17 August 2017

Charles W Pemble

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 November 2007

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Expert Opinion on Investigational Drugs

17 August 2017

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17 August 2017

16

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17 August 2017

11

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17 August 2017

1817-1829

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On the Origin of Cancer Cells

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Going malignant: the hypoxia-cancer connection in the prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Fatty acid synthase, a proficient multifunctional enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Fatty acid synthase and cancer: new application of an old pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Increased lipogenesis in cancer cells: new players, novel targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: an interinstitutional study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Trafficking and signaling by fatty-acylated and prenylated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Use of analogs and inhibitors to study the functional significance of protein palmitoylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Fatty acid synthase: a metabolic oncogene in prostate cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Key role of mitochondria in cerulenin-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

A flexible route to (5R)-thiolactomycin, a naturally occurring inhibitor of fatty acid synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Total synthesis and comparative analysis of orlistat, valilactone, and a transposed orlistat derivative: Inhibitors of fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Inhibition of fatty acid synthase by polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Structure-activity relationship of polyphenols that inhibit fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Inhibitory effects of flavonoids on animal fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

ATP citrate lyase inhibition can suppress tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

ATP citrate lyase is an important component of cell growth and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Structure and function of animal fatty acid synthase

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Structural and functional organization of the animal fatty acid synthase

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Structure and molecular organization of mammalian fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Positron emission tomography for prostate, bladder, and renal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma☆

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1817

10.1517/13543784.16.11.1817

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference