The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism. (Q37035832)

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1 April 2020

title

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism (English)

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Constantine S. Tam

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Joshua Fein

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Ian J Majewski

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David C Huang

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Andrew W. Roberts

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Anthony Letai

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author name string

Jing Deng

2

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John F Seymour

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Su Young Kim

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Lijian Yu

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Jennifer R Brown

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David Westerman

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Eric G Si

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David Segal

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Sari L Heitner Enschede

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Matthew S Davids

15

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language of work or name

English

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publication date

11 April 2016

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volume

127

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issue

25

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1 April 2020

page(s)

3215-3224

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Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

1 April 2020

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Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic Leukemia

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Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib

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Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia

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Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia

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Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

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A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

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Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy

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Clearance of apoptotic cells: implications in health and disease

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29 September 2017

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PubMed

https://pubmed.ncbi.nlm.nih.gov/27069256

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2016-01-688796

1 reference

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1 April 2020

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1 April 2020

PubMed publication ID

27069256

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