Biology of HIF-1alpha (Q37079724)

18 August 2017

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title

Biology of HIF-1alpha (English)

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18 August 2017

A Weidemann

1

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PubMed ID

18259201

18 August 2017

R S Johnson

series ordinal

2

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18 August 2017

15 February 2008

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Cell Death & Differentiation

18 August 2017

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18 August 2017

15

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18 August 2017

621-627

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18 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/cdd.2008.12

18 August 2017

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cites work

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Activation of the HIF pathway in cancer

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

The PAS superfamily: sensors of environmental and developmental signals

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Induction of HIF-1alpha in response to hypoxia is instantaneous

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Isolation of a tumor factor responsible for angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

The hypoxic response of tumors is dependent on their microenvironment.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Expression of hypoxia-inducible factor 1? in brain tumors

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

The von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Regulation of HIF-1alpha stability through S-nitrosylation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

HIF-1alpha is essential for myeloid cell-mediated inflammation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.12

7 January 2021

Identifiers

DOI

10.1038/CDD.2008.12

1 reference

PubMed ID

18259201

Dimensions Publication ID

18 August 2017

0 references

1 reference

PubMed ID

18259201