Pathogenesis of type 2 diabetes (Q37083597)

18 August 2017

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title

Pathogenesis of type 2 diabetes (English)

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18 August 2017

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1

Michael Stumvoll

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18 August 2017

Barry J Goldstein

2

1 reference

PubMed ID

18271503

18 August 2017

Timon W van Haeften

series ordinal

3

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18 August 2017

1 January 2007

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18 August 2017

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18 August 2017

32

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18 August 2017

19-37

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18 August 2017

1-2

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Type 2 diabetes: principles of pathogenesis and therapy

18 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Carbohydrate metabolism in non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Extended longevity in mice lacking the insulin receptor in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

IRS proteins and the common path to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Cellular mechanisms of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Adiponectin: A novel adipokine linking adipocytes and vascular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Prevention of fat-induced insulin resistance by salicylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Obesity-induced inflammatory changes in adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Insulin receptors are widely distributed in human brain and bind human and porcine insulin with equal affinity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Obesity, diabetes and the central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Role of brain insulin receptor in control of body weight and reproduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Pleiotropic effects of fatty acids on pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Islet amyloid and type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Risk of diabetes in offspring of parents with non-insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Candidate genes for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Thiazolidinediones: an update.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

PPARgamma, the ultimate thrifty gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Calpains play a role in insulin secretion and action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07435800701743810

10.1080/07435800701743810

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18271503