The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions (Q37095351)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23678007%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions (English)

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1 March 2020

3

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1 March 2020

author name string

Maria Mastrogiannaki

series ordinal

1

1 reference

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1 March 2020

Pavle Matak

series ordinal

2

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1 March 2020

language of work or name

English

0 references

publication date

15 May 2013

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1 March 2020

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1 March 2020

volume

122

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issue

6

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1 March 2020

page(s)

885-892

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Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice

1 March 2020

cites work

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Duodenal reductase activity and spleen iron stores are reduced and erythropoiesis is abnormal in Dcytb knockout mice exposed to hypoxic conditions

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Two to tango: regulation of Mammalian iron metabolism

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis

29 September 2017

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29 September 2017

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A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

29 September 2017

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Steap proteins: implications for iron and copper metabolism

29 September 2017

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Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

29 September 2017

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Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

29 September 2017

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Regulation of systemic iron homeostasis: how the body responds to changes in iron demand

29 September 2017

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Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

29 September 2017

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29 September 2017

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29 September 2017

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Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice

29 September 2017

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29 September 2017

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29 September 2017

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

29 September 2017

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Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia

29 September 2017

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29 September 2017

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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

29 September 2017

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Physiology and molecular biology of dietary iron absorption

29 September 2017

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A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption.

29 September 2017

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Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1

29 September 2017

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Pathways of iron absorption

29 September 2017

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

29 September 2017

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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

29 September 2017

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

29 September 2017

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An iron-regulated ferric reductase associated with the absorption of dietary iron

29 September 2017

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A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

29 September 2017

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Genes that modify the hemochromatosis phenotype in mice

29 September 2017

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

29 September 2017

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Cloning and characterization of a mammalian proton-coupled metal-ion transporter

29 September 2017

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Iron regulatory proteins control a mucosal block to intestinal iron absorption

29 September 2017

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1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

27 June 2018

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HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.

27 June 2018

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Tumour necrosis factor alpha causes hypoferraemia and reduced intestinal iron absorption in mice.

27 June 2018

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Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs

27 June 2018

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Effect of altitude on erythropoiesis.

27 June 2018

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Giving anemia a boost with inhibitors of prolyl hydroxylase.

27 June 2018

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3 September 2018

1 reference

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Effect of hypoxia on the expression of iron regulatory proteins 1 and the mechanisms involved

3 September 2018

1 reference

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Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743464

Not all DMT1 mutations lead to iron overload.

3 September 2018

1 reference

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Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism.

3 September 2018

1 reference

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Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells.

3 September 2018

1 reference

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Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2).

3 September 2018

1 reference

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Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743464

Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice.

3 September 2018

1 reference

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Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis.

3 September 2018

1 reference

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Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

3 September 2018

1 reference

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Regulation of hepcidin expression at high altitude

3 September 2018

1 reference

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High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

20 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743464

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

20 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743464

Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure

4 December 2018

1 reference

12 December 2020

In vivo studies on the relationship between intestinal iron (Fe3+) absorption, hypoxia and erythropoiesis in the mouse

1 reference

12 December 2020

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

1 reference

12 December 2020

Hypoferraemia during the early inflammatory response is dependent on tumour necrosis factor activity in a murine model of protracted peritonitis

1 reference

12 December 2020

Tumour necrosis factor alpha regulates iron transport and transporter expression in human intestinal epithelial cells

1 reference

12 December 2020

Dietary iron levels and hypoxia independently affect iron absorption in mice

1 reference

12 December 2020

The influence of hypoxia on iron absorption in the rat

1 reference

12 December 2020

The polycythemia of high altitudes: iron metabolism and related aspects

1 reference

12 December 2020

Intestinal ferritin H is required for an accurate control of iron absorption

1 reference

12 December 2020

Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency

1 reference

12 December 2020

10.1182/BLOOD-2012-11-427765

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23678007%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23678007%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23678007%20AND%20SRC:MED&resulttype=core&format=json