Molecular strategies to inhibit the replication of RNA viruses (Q37099776)

18 August 2017

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Molecular strategies to inhibit the replication of RNA viruses (English)

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18 August 2017

Erik De Clercq

2

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Johan Neyts

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Johan Neyts

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3

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Pieter Leyssen

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1

object named as

Pieter Leyssen

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18 August 2017

4 February 2008

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18 August 2017

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18 August 2017

78

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18 August 2017

1

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18 August 2017

9-25

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Placebo-controlled, double-blind trial of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome in North America.

18 August 2017

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12 December 2020

Modelling how ribavirin improves interferon response rates in hepatitis C virus infection

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12 December 2020

Carbohydrate-binding agents: a potential future cornerstone for the chemotherapy of enveloped viruses?

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12 December 2020

The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase

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12 December 2020

Conversion of viramidine to ribavirin in vivo by adenosine deaminase and its inhibition by 2'-deoxycoformycin.

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12 December 2020

Treatment of Marburg and Ebola hemorrhagic fevers: a strategy for testing new drugs and vaccines under outbreak conditions

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12 December 2020

Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins

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12 December 2020

Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents

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12 December 2020

Ribavirin prophylaxis and therapy for experimental argentine hemorrhagic fever

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12 December 2020

A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity

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12 December 2020

Mechanism of action of T-705 against influenza virus

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12 December 2020

Treating hepatitis C: can you teach old dogs new tricks?

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12 December 2020

The potentiating effect of ribavirin on interferon in the treatment of hepatitis C: lack of evidence for ribavirin-induced viral mutagenesis.

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12 December 2020

Inhibitors of IMP dehydrogenase prevent sindbis virus replication and reduce GTP levels in Aedes albopictus cells

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12 December 2020

Inhibition of bovine viral diarrhea virus (BVDV) by mizoribine: synergistic effect of combination with interferon-alpha

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12 December 2020

Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate

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12 December 2020

Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy

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12 December 2020

The broad spectrum antiviral nucleoside ribavirin as a substrate for a viral RNA capping enzyme.

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12 December 2020

Neuraminidase inhibitors for influenza

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12 December 2020

Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection.

1 reference

12 December 2020

In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease

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12 December 2020

Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.

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12 December 2020

3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice

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12 December 2020

Synthesis of influenza neuraminidase inhibitors

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12 December 2020

Initial Binding of the Broad Spectrum Antiviral Nucleoside Ribavirin to the Hepatitis C Virus RNA Polymerase

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12 December 2020

Crimean Congo-haemorrhagic fever treated with oral ribavirin

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12 December 2020

Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad-spectrum antiviral drug

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12 December 2020

Treatment of acute Nipah encephalitis with ribavirin.

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12 December 2020

Inhibition of Respiratory Syncytial Virus Fusion by the Small Molecule VP-14637 via Specific Interactions with F Protein

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12 December 2020

Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses

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12 December 2020

Inhibitory effect of selected antiviral compounds on measles (SSPE) virus replication in vitro

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12 December 2020

Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections.

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12 December 2020

Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus

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12 December 2020

The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target

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12 December 2020

Mutagenic effects of ribavirin and response to interferon/ribavirin combination therapy in chronic hepatitis C.

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12 December 2020

Targeting hepatitis C virus translation: stopping HCV where it starts.

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12 December 2020

Entry of parainfluenza virus into cells as a target for interrupting childhood respiratory disease

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12 December 2020

Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase

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12 December 2020

SARS: systematic review of treatment effects

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12 December 2020

Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine

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12 December 2020

Lassa virus infection of rhesus monkeys: pathogenesis and treatment with ribavirin

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12 December 2020

Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses

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12 December 2020

Effect of 1-beta-D-ribofuranosyl1-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on herpes and vaccinia keratitis and encephalitis in laboratory animals

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12 December 2020

Potential of antiviral therapy and prophylaxis for controlling RNA viral infections of livestock

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12 December 2020

Rational design of potent sialidase-based inhibitors of influenza virus replication

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12 December 2020

The therapeutic efficacy of ribamidil and virazole in experimental Lassa fever in monkeys

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12 December 2020

The efficacy of oral ribavirin in the treatment of crimean-congo hemorrhagic fever in Iran

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12 December 2020

Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus

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12 December 2020

In vitro and in vivo activities of T-705 and oseltamivir against influenza virus

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12 December 2020

Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine

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12 December 2020

Analysis of Ribavirin Mutagenicity in Human Hepatitis C Virus Infection

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12 December 2020

Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses

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12 December 2020

Biophysical characterization of HRC peptide analogs interaction with heptad repeat regions of the SARS-coronavirus Spike fusion protein core

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12 December 2020

Studies on the mechanism of the antiviral activity of ribavirin against reovirus.

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12 December 2020

Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties

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12 December 2020

Comparative activities of several nucleoside analogs against influenza A, B, and C viruses in vitro

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12 December 2020

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

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12 December 2020

Pradimicin A, a carbohydrate-binding nonpeptidic lead compound for treatment of infections with viruses with highly glycosylated envelopes, such as human immunodeficiency virus

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12 December 2020

In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combination

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12 December 2020

Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus

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12 December 2020

Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon

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12 December 2020

Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase

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12 December 2020

Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin

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12 December 2020

Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice

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12 December 2020

Antiviral action of ribavirin in chronic hepatitis C.

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12 December 2020

Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C.

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12 December 2020

The role of antivirals in the control of influenza.

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12 December 2020

Influenza: lessons from past pandemics, warnings from current incidents.

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12 December 2020

Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses

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12 December 2020

Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis.

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12 December 2020

In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease

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12 December 2020

Ribavirin Induces Error-Prone Replication of GB Virus B in Primary Tamarin Hepatocytes

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12 December 2020

Rhinovirus chemotherapy

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12 December 2020

Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern

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12 December 2020

In Vitro and In Vivo Activities of T-705 against Arenavirus and Bunyavirus Infections

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12 December 2020

Tropolone and its derivatives as inhibitors of the helicase activity of hepatitis C virus nucleotide triphosphatase/helicase

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12 December 2020

Poly(I)-Poly(C12U) but Not Ribavirin Prevents Death in a Hamster Model of Nipah Virus Infection

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12 December 2020

Antiviral drug discovery and development: where chemistry meets with biomedicine

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12 December 2020

Highly pathogenic RNA viral infections: challenges for antiviral research.

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12 December 2020

The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture

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12 December 2020

In vitro and in vivo influenza virus-inhibitory effects of viramidine

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12 December 2020

Inhibitory effects of antiviral compounds on respiratory syncytial virus replication in vitro

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12 December 2020

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

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12 December 2020

Current and future antiviral therapy of severe seasonal and avian influenza

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12 December 2020

The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.

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12 December 2020

Ribavirin causes error catastrophe during Hantaan virus replication.

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12 December 2020

Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children

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12 December 2020

The anti-yellow fever virus activity of ribavirin is independent of error-prone replication

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12 December 2020

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

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12 December 2020

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity

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12 December 2020

Nuclear import in viral infections

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12 December 2020

Challenges and successes in developing new therapies for hepatitis C.

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12 December 2020

Hepatitis C virus: virology, diagnosis and management of antiviral therapy.

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12 December 2020

Treatment of hantavirus pulmonary syndrome

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12 December 2020

ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE (AMANTADINE).

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12 December 2020

RSV604, a novel inhibitor of respiratory syncytial virus replication

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12 December 2020

Molecular approaches for the treatment of hemorrhagic fever virus infections.

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12 December 2020

Inhibition of hendra virus fusion.

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12 December 2020

Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5

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12 December 2020

Experimental Lassa fever virus infection successfully treated with ribavirin

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12 December 2020

Application of real-time PCR for testing antiviral compounds against Lassa virus, SARS coronavirus and Ebola virus in vitro

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12 December 2020

Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases

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12 December 2020

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

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12 December 2020

Antiviral agents active against influenza A viruses.

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12 December 2020

Effect of ribavirin, levovirin and viramidine on liver toxicological gene expression in rats

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12 December 2020

An NS3 serine protease inhibitor abrogates replication of subgenomic hepatitis C virus RNA.

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12 December 2020

Does antiviral therapy have a role in the control of Japanese encephalitis?

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12 December 2020

Mechanisms of action of ribavirin against distinct viruses

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12 December 2020

Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin.

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12 December 2020

New opportunities for field research on the pathogenesis and treatment of Lassa fever

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12 December 2020

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

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12 December 2020

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

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12 December 2020

Design of wide-spectrum inhibitors targeting coronavirus main proteases

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12 December 2020

Targeting glycosylation as a therapeutic approach

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12 December 2020

Treatment of Crimean-Congo hemorrhagic fever

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12 December 2020

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

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12 December 2020

2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus.

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12 December 2020

Mutations that confer resistance to mycophenolic acid and ribavirin on sindbis virus map to the nonstructural protein nsP1

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12 December 2020

Antiviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse model

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12 December 2020

Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses

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12 December 2020

Crystal structure of Dengue virus NS3 protease in complex with a Bowman-Birk inhibitor: implications for flaviviral polyprotein processing and drug design

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12 December 2020

Mechanism of action of a pestivirus antiviral compound

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12 December 2020

Animal models of highly pathogenic RNA viral infections: encephalitis viruses

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12 December 2020

Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor

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12 December 2020

Ribavirin therapy for Nipah virus infection

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12 December 2020

Viral infection and host defense

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12 December 2020

Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China

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12 December 2020

Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target

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12 December 2020

Inhibitory effect of selected antiviral compounds on arenavirus replication in vitro

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12 December 2020

Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms

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12 December 2020

A novel antiviral agent which inhibits the endonuclease of influenza viruses

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12 December 2020

The broad spectrum antiviral agent ribavirin inhibits capping of mRNA

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12 December 2020

In vitro and in vivo activities of anti-influenza virus compound T-705.

1 reference

12 December 2020

The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase

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12 December 2020

The ribavirin analog ICN 17261 demonstrates reduced toxicity and antiviral effects with retention of both immunomodulatory activity and reduction of hepatitis-induced serum alanine aminotransferase levels

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12 December 2020

Specific inhibition of hepatitis C virus replication by cyclosporin A.

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12 December 2020

Absorption, metabolism, and excretion of [14C]viramidine in humans

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12 December 2020

Intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience. Ribavirin Study Group.

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12 December 2020

Mizoribine inhibits hepatitis C virus RNA replication: effect of combination with interferon-alpha

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12 December 2020

Antiviral action and selectivity of 6-azauridine

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12 December 2020

A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.

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12 December 2020

RNA virus error catastrophe: direct molecular test by using ribavirin

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12 December 2020

Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent

1 reference

12 December 2020

Prospective, Double-Blind, Concurrent, Placebo-Controlled Clinical Trial of Intravenous Ribavirin Therapy of Hemorrhagic Fever with Renal Syndrome

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12 December 2020

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

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12 December 2020

In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses

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12 December 2020

In vitro assembly of PB2 with a PB1-PA dimer supports a new model of assembly of influenza A virus polymerase subunits into a functional trimeric complex

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12 December 2020

Treatment of Argentine hemorrhagic fever

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12 December 2020

The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro

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12 December 2020

Antiviral effects of an iminosugar derivative on flavivirus infections

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12 December 2020

Anti-enterovirus activity and structure–activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles

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12 December 2020

Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile.

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12 December 2020

Monitoring of clinical and laboratory data in two cases of imported Lassa fever

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12 December 2020

Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.

1 reference

12 December 2020

The carbohydrate-binding plant lectins and the non-peptidic antibiotic pradimicin A target the glycans of the coronavirus envelope glycoproteins

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12 December 2020

Treatment of yellow fever

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12 December 2020

Lassa fever. Effective therapy with ribavirin

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12 December 2020

An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-β-d-ribofuranoside

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12 December 2020

Inhibition of Crimean-Congo hemorrhagic fever viral infectivity yields in vitro by ribavirin

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12 December 2020

10.1016/J.ANTIVIRAL.2008.01.004

Identifiers

DOI

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18 August 2017

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PubMed ID

18313769