Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications (Q37104877)

18 August 2017

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title

Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications (English)

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18 August 2017

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Harold E Bays

1

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18 August 2017

Ann P Tighe

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2

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18 August 2017

Richard Sadovsky

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3

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18 August 2017

Michael H Davidson

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4

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18 August 2017

1 March 2008

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Expert Review of Cardiovascular Therapy

18 August 2017

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18 August 2017

6

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18 August 2017

391-409

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18 August 2017

3

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Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring Study

18 August 2017

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey

21 January 2018

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Dyslipidemia in visceral obesity: mechanisms, implications, and therapy

21 January 2018

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The relationship of body mass index to diabetes mellitus, hypertension and dyslipidaemia: comparison of data from two national surveys

21 January 2018

1 reference

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Adiposopathy: how do diet, exercise and weight loss drug therapies improve metabolic disease in overweight patients?

21 January 2018

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Adiposopathy: why do adiposity and obesity cause metabolic disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Long-term follow-up of patients with acute hypertriglyceridemia-induced pancreatitis

21 January 2018

1 reference

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Issues in hyperlipidemic pancreatitis

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Diagnosis of familial combined hyperlipidemia based on lipid phenotype expression in 32 families: results of a 5-year follow-up study

21 January 2018

1 reference

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Unraveling the complex genetics of familial combined hyperlipidemia

21 January 2018

1 reference

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Acquired lipoprotein lipase deficiency associated with chronic urticaria. A new etiology for type I hyperlipoproteinemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Effect of exercise duration on postprandial hypertriglyceridemia in men with metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Decreasing the plasma triglyceride level in hypertriglyceridemia-induced pancreatitis in pregnancy: a case report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Pharmacotherapy for dyslipidaemia – current therapies and future agents

21 January 2018

1 reference

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Regulation of plasma triglycerides in insulin resistance and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Mutations in exon 3 of the lipoprotein lipase gene segregating in a family with hypertriglyceridemia, pancreatitis, and non-insulin-dependent diabetes

21 January 2018

1 reference

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Adiposopathy: sick fat causes high blood sugar, high blood pressure and dyslipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach

21 January 2018

1 reference

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Etiopathogenesis of nonalcoholic steatohepatitis

21 January 2018

1 reference

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A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury.

21 January 2018

1 reference

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Fat Modification in the Diabetes Diet

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

New perspectives on atherogenesis: role of abnormal triglyceride-rich lipoprotein metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Hypertriglyceridemia: its etiology, effects and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Lipoprotein distribution in the metabolic syndrome, type 2 diabetes mellitus, and familial combined hyperlipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Influence of dietary carbohydrate and fat on LDL and HDL particle distributions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Hypertriglyceridemia as a cardiovascular risk factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction

21 January 2018

1 reference

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Apolipoprotein B versus non-high-density lipoprotein cholesterol: and the winner is...

21 January 2018

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Torcetrapib/atorvastatin combination therapy

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Low-density lipoprotein size, pravastatin treatment, and coronary events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Postprandial, but not postabsorptive low-density lipoproteins increase the expression of intercellular adhesion molecule-1 in human aortic endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Impaired postprandial apolipoprotein-B48 metabolism in the obese, insulin-resistant JCR:LA-cp rat: increased atherogenicity for the metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Postprandial lipoprotein metabolism, genes and risk of cardiovascular disease.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Atherogenesis: a postprandial phenomenon

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Postprandial triglycerides and blood coagulation

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

The biochemistry of n-3 polyunsaturated fatty acids

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease

21 January 2018

1 reference

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Fish intake, contaminants, and human health: evaluating the risks and the benefits

21 January 2018

1 reference

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n-3 fatty acids and lipoproteins: comparison of results from human and animal studies

21 January 2018

1 reference

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Treatment of hypertriglyceridemia with omega-3 fatty acids: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Effects of n-3 fatty acids on postprandial triacylglycerol and hormone concentrations in normal subjects.

21 January 2018

1 reference

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Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism

21 January 2018

1 reference

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Clinical overview of Omacor: a concentrated formulation of omega-3 polyunsaturated fatty acids

21 January 2018

1 reference

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Effect of alpha linolenic acid on cardiovascular risk markers: a systematic review

21 January 2018

1 reference

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Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype

21 January 2018

1 reference

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The bioavailability and pharmacodynamics of different concentrations of omega-3 acid ethyl esters.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Safety considerations with omega-3 fatty acid therapy

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Differentiating prescription omega-3-acid ethyl esters (P-OM3) from dietary-supplement omega-3 fatty acids

21 January 2018

1 reference

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Variable hypocoagulant effect of fish oil intake in humans: modulation of fibrinogen level and thrombin generation

21 January 2018

1 reference

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Expert opinion: omega-3 fatty acids and bleeding-cause for concern?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Why do omega-3 fatty acids lower serum triglycerides?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Trans geometric isomers of EPA decrease LXRalpha-induced cellular triacylglycerol via suppression of SREBP-1c and PGC-1beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Activation of PPARdelta alters lipid metabolism in db/db mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

The farnesoid X receptor induces very low density lipoprotein receptor gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Regulatory effects of HMG CoA reductase inhibitor and fish oils on apolipoprotein B-100 kinetics in insulin-resistant obese male subjects with dyslipidemia.

21 January 2018

1 reference

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Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Regulation of the production and catabolism of plasma low density lipoproteins in hypertriglyceridemic subjects. Effect of weight loss

21 January 2018

1 reference

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Omega-3 fatty acids in inflammation and autoimmune diseases

21 January 2018

1 reference

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Influence of topical administration of n-3 and n-6 essential and n-9 nonessential fatty acids on the healing of cutaneous wounds

21 January 2018

1 reference

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Fish-oil dietary supplementation in patients with Raynaud's phenomenon: a double-blind, controlled, prospective study

21 January 2018

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Diet as a risk factor for atopy and asthma

21 January 2018

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The role of fish oil/omega-3 fatty acids in the treatment of IgA nephropathy

21 January 2018

1 reference

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Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction

21 January 2018

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Clinical efficacy of n-3 fatty acid supplementation in patients with asthma

21 January 2018

1 reference

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Women and omega-3 Fatty acids

21 January 2018

1 reference

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Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial.

21 January 2018

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Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study.

21 January 2018

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Omega-3 fatty acids in the treatment of psychiatric disorders

21 January 2018

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MRI and neuropsychological improvement in Huntington disease following ethyl-EPA treatment

21 January 2018

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Multiple sclerosis and nutrition

21 January 2018

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A pilot open case series of ethyl-EPA supplementation in the treatment of anorexia nervosa

21 January 2018

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Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression

21 January 2018

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N-3 fatty acids and pregnancy outcomes

21 January 2018

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The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina

21 January 2018

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Is there a case for n-3 fatty acid supplementation in cystic fibrosis?

21 January 2018

1 reference

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n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review

21 January 2018

1 reference

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Are omega-3 fatty acids the most important nutritional modulators of coronary heart disease risk?

21 January 2018

1 reference

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Fish intake and risk of incident atrial fibrillation

21 January 2018

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The role of omega-3 fatty acids in cardiac protection: an overview

21 January 2018

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Immediate effects of n-3 fatty acid infusion on the induction of sustained ventricular tachycardia.

21 January 2018

1 reference

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Effect of n-3 fatty acids from fish on electrocardiographic characteristics in patients with frequent premature ventricular complexes.

21 January 2018

1 reference

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Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial

21 January 2018

1 reference

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Effects of dietary fat intake in sudden death: reduction of death with omega-3 fatty acids

21 January 2018

1 reference

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Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART).

21 January 2018

1 reference

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Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies

21 January 2018

1 reference

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Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and post-prandial lipid metabolism in healthy subjects

21 January 2018

1 reference

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An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Dietary fat and postprandial lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

The role of omega-3 fatty acids in cardiovascular disease

21 January 2018

1 reference

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Omega-3 fatty acids and inflammation

21 January 2018

1 reference

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Inhibition of leukocyte-endothelial interactions by oxidized omega-3 fatty acids: a novel mechanism for the anti-inflammatory effects of omega-3 fatty acids in fish oil.

21 January 2018

1 reference

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Correlation of serum triglyceride and its reduction by omega-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins.

21 January 2018

1 reference

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The effect of concentrated n-3 fatty acids versus gemfibrozil on plasma lipoproteins, low density lipoprotein heterogeneity and oxidizability in patients with hypertriglyceridemia.

21 January 2018

1 reference

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Triglycerides and the Risk of Coronary Heart Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.6.3.391

Prevalence and Prognostic Impact of Subclinical Cardiovascular Disease in Individuals With the Metabolic Syndrome and Diabetes

21 January 2018

1 reference

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Effects of n-3 fatty acids on cartilage metabolism

21 January 2018

1 reference

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Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1586/14779072.6.3.391

1 reference

18 August 2017

1 reference