Small GTP-binding proteins and their regulators in cardiac hypertrophy (Q37109688)

18 August 2017

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title

Small GTP-binding proteins and their regulators in cardiac hypertrophy (English)

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18 August 2017

1

Frank Lezoualc'h

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Mélanie Métrich

object named as

Mélanie Métrich

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author name string

Isabelle Hmitou

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3

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PubMed ID

18339399

18 August 2017

Nicolas Duquesnes

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4

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PubMed ID

18339399

18 August 2017

Eric Morel

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5

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18 August 2017

13 February 2008

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Journal of Molecular and Cellular Cardiology

18 August 2017

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18 August 2017

44

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18 August 2017

4

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18 August 2017

623-632

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Hypertrophy of the heart: a new therapeutic target?

18 August 2017

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Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence

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Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study

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The epidemiology of heart failure: the Framingham Study

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Does load-induced ventricular hypertrophy progress to systolic heart failure?

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Signaling pathways for cardiac hypertrophy and failure

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Regulation of cardiac hypertrophy by intracellular signalling pathways

7 January 2021

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Small guanine nucleotide-binding proteins and myocardial hypertrophy

7 January 2021

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Small GTP-binding proteins

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Role of raf proteins in cardiac hypertrophy and cardiomyocyte survival

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The Rac and Rho hall of fame: a decade of hypertrophic signaling hits

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Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses

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The Ras superfamily at a glance

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GEFs and GAPs: critical elements in the control of small G proteins

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Small GTP-binding protein-coupled receptors

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Hyperactive Ras in developmental disorders and cancer

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Rho GTPases: biochemistry and biology

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Rho GTPases and the actin cytoskeleton

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

7 January 2021

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

7 January 2021

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

7 January 2021

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7 January 2021

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Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf.

7 January 2021

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The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase

7 January 2021

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Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways

7 January 2021

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A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy

7 January 2021

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Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure

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The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel

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RhoA GTPase regulates L-type Ca2+ currents in cardiac myocytes

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Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved.

7 January 2021

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Requirement of Rac1 in the development of cardiac hypertrophy.

7 January 2021

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Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice

7 January 2021

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Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1

7 January 2021

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Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy

7 January 2021

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Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.

7 January 2021

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Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart.

7 January 2021

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Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy

7 January 2021

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Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy

7 January 2021

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Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload

7 January 2021

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Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

7 January 2021

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Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

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Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

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Further delineation of cardiac abnormalities in Costello syndrome

7 January 2021

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Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

7 January 2021

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Germline gain-of-function mutations in RAF1 cause Noonan syndrome

7 January 2021

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Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases.

7 January 2021

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HRAS mutation analysis in Costello syndrome: genotype and phenotype correlation.

7 January 2021

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MicroRNA-133 controls cardiac hypertrophy

7 January 2021

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MicroRNAs play an essential role in the development of cardiac hypertrophy

7 January 2021

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

7 January 2021

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Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.

7 January 2021

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Regulation of Ras·GTP Loading and Ras-Raf Association in Neonatal Rat Ventricular Myocytes by G Protein-coupled Receptor Agonists and Phorbol Ester

7 January 2021

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Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1

7 January 2021

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Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho.

7 January 2021

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Ras and rho are required for galphaq-induced hypertrophic gene expression in neonatal rat cardiac myocytes

7 January 2021

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Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists

7 January 2021

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Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy

7 January 2021

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The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy

7 January 2021

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Isoproterenol and cAMP regulation of the human brain natriuretic peptide gene involves Src and Rac

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cAMP-binding protein Epac induces cardiomyocyte hypertrophy.

7 January 2021

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Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation

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Regulator of G-protein signalling 3 redirects prototypical Gi-coupled receptors from Rac1 to RhoA activation

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Coupling receptor tyrosine kinases to Rho GTPases--GEFs what's the link

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Signaling interplay in Ras superfamily function

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GEF what? Dock180 and related proteins help Rac to polarize cells in new ways

7 January 2021

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Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly

7 January 2021

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Structural analysis of obscurin gene in hypertrophic cardiomyopathy

7 January 2021

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Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing.

7 January 2021

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The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.

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1 reference

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AKAP-Lbc: a molecular scaffold for the integration of cyclic AMP and Rho transduction pathways

7 January 2021

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The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

7 January 2021

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A family of cAMP-binding proteins that directly activate Rap1

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Cell physiology of cAMP sensor Epac

7 January 2021

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Epac and the cardiovascular system

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Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation

7 January 2021

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Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

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Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.

7 January 2021

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Epac proteins: multi-purpose cAMP targets

7 January 2021

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Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition

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Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

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The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

7 January 2021

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Going to cAMP just got more complicated

7 January 2021

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The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes

7 January 2021

1 reference

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Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes

7 January 2021

1 reference

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Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes

7 January 2021

1 reference

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Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

7 January 2021

1 reference

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Ral GDP dissociation stimulator and Ral GTPase are involved in myocardial hypertrophy.

7 January 2021

1 reference

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Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

7 January 2021

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Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras

7 January 2021

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Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy

7 January 2021

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Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex

7 January 2021

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An alliance between Ras GTPase-activating protein, filamin C, and Ras GTPase-activating protein SH3 domain-binding protein regulates myocyte growth

7 January 2021

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Regulation of Rho proteins by phosphorylation in the cardiovascular system

7 January 2021

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Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle

7 January 2021

1 reference

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Integrin-linked kinase at the heart of cardiac contractility, repair, and disease.

7 January 2021

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Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy

7 January 2021

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Rho kinases in cardiovascular physiology and pathophysiology

7 January 2021

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The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes--possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy.

7 January 2021

1 reference

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Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy

7 January 2021

1 reference

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Long-Term Treatment With a Specific Rho-Kinase Inhibitor Suppresses Cardiac Allograft Vasculopathy in Mice

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1 reference

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Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system

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1 reference

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Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice

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p21-activated kinases in cancer

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p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility

7 January 2021

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Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

7 January 2021

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Impact of HMG CoA reductase inhibition on small GTPases in the heart

7 January 2021

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The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B

7 January 2021

1 reference

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Activation of NADPH oxidase during progression of cardiac hypertrophy to failure

7 January 2021

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Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase

7 January 2021

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Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice.

7 January 2021

1 reference

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Role of reactive oxygen species and NAD(P)H oxidase in alpha(1)-adrenoceptor signaling in adult rat cardiac myocytes

7 January 2021

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Mechanisms of statin-mediated inhibition of small G-protein function

7 January 2021

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Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells

7 January 2021

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Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy

7 January 2021

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Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation

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Prevention of cardiac hypertrophy by atorvastatin in a transgenic rabbit model of human hypertrophic cardiomyopathy

7 January 2021

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Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling

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Enhancement of the recycling and activation of beta-adrenergic receptor by Rab4 GTPase in cardiac myocytes

7 January 2021

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Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart

7 January 2021

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Rad GTPase deficiency leads to cardiac hypertrophy

7 January 2021

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10.1016/J.YJMCC.2008.01.011

7 January 2021

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18339399