p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β (Q37137884)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27427981%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β (English)

1 reference

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18 March 2020

0 references

0 references

Enrique Hernández-Jiménez

2

1 reference

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18 March 2020

Rahman Shokri

3

1 reference

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18 March 2020

Dimitrios Balomenos

9

1 reference

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18 March 2020

author name string

Gorjana Rackov

1

1 reference

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18 March 2020

Lorena Carmona-Rodríguez

4

1 reference

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18 March 2020

Santos Mañes

5

1 reference

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18 March 2020

Melchor Álvarez-Mon

6

1 reference

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18 March 2020

Eduardo López-Collazo

7

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18 March 2020

Carlos Martínez-A

8

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18 March 2020

language of work or name

English

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publication date

18 July 2016

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Journal of Clinical Investigation

18 March 2020

published in

1 reference

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18 March 2020

volume

126

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18 March 2020

page(s)

3089-3103

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18 March 2020

issue

8

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The multifaceted biology of plasmacytoid dendritic cells

18 March 2020

cites work

1 reference

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An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation

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Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation

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Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

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M1 and M2 Macrophages: Oracles of Health and Disease

14 September 2017

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Genomic responses in mouse models poorly mimic human inflammatory diseases

14 September 2017

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CXCL5 limits macrophage foam cell formation in atherosclerosis

14 September 2017

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Macrophage plasticity and polarization: in vivo veritas

14 September 2017

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Transcriptional regulation of macrophage polarization: enabling diversity with identity

14 September 2017

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Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritis

14 September 2017

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CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

14 September 2017

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

14 September 2017

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Type I interferon: friend or foe?

14 September 2017

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Alternative activation of macrophages: mechanism and functions

14 September 2017

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Two physically, functionally, and developmentally distinct peritoneal macrophage subsets

14 September 2017

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Endotoxin tolerance: new mechanisms, molecules and clinical significance

14 September 2017

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Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.

14 September 2017

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Macrophage diversity and polarization in atherosclerosis: a question of balance

14 September 2017

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Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling

14 September 2017

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The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages

14 September 2017

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Exploring the full spectrum of macrophage activation

14 September 2017

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Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease

14 September 2017

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Monocytes from cystic fibrosis patients are locked in an LPS tolerance state: down-regulation of TREM-1 as putative underlying mechanism.

14 September 2017

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14 September 2017

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Signaling to NF-kappaB by Toll-like receptors

14 September 2017

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Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model

14 September 2017

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Myeloid differentiation factor 88-independent Toll-like receptor pathway: Sustaining inflammation or promoting tolerance?

14 September 2017

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Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling.

14 September 2017

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Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis

14 September 2017

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Should we inhibit type I interferons in sepsis?

14 September 2017

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Biochemical and functional characterization of three activated macrophage populations.

14 September 2017

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The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production

14 September 2017

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Monocyte and macrophage heterogeneity

14 September 2017

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Negative regulation of toll-like receptor-mediated immune responses

14 September 2017

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DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit

14 September 2017

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The chemokine system in diverse forms of macrophage activation and polarization

14 September 2017

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BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages

14 September 2017

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Toll-like receptor signalling

14 September 2017

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Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients

14 September 2017

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IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages

14 September 2017

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Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

14 September 2017

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The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome

14 September 2017

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14 September 2017

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IRAK-M is a negative regulator of Toll-like receptor signaling

14 September 2017

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The p50-homodimer mechanism in tolerance to LPS.

14 September 2017

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Regulation of an essential innate immune response by the p50 subunit of NF-kappaB.

14 September 2017

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LPS tolerance in monocytes/macrophages: three 3' cytosins are required in the DNA binding motif for detection of upregulated NF-kappa B p50 homodimers

14 September 2017

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

14 September 2017

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Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors

14 September 2017

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Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20.

14 September 2017

1 reference

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Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance

14 September 2017

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Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade

14 September 2017

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TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

14 September 2017

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Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1α.

29 September 2017

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NFκB2/p100 is a key factor for endotoxin tolerance in human monocytes: a demonstration using primary human monocytes from patients with sepsis.

29 September 2017

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Endotoxin tolerance drives neutrophil to infectious site

27 June 2018

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Type I interferon drives tumor necrosis factor-induced lethal shock

27 June 2018

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CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells

27 June 2018

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Btk regulates macrophage polarization in response to lipopolysaccharide.

27 June 2018

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Pharmacological inhibition of type I interferon signaling protects mice against lethal sepsis.

3 September 2018

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Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients.

3 September 2018

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p21(waf1/CIP1), a CDK inhibitor and a negative feedback system that controls macrophage activation.

3 September 2018

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Regulation of macrophage activation and septic shock susceptibility via p21(WAF1/CIP1).

3 September 2018

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p21CIP1/WAF1 controls proliferation of activated/memory T cells and affects homeostasis and memory T cell responses.

3 September 2018

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Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis.

3 September 2018

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Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.

3 September 2018

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NF-kappaB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance

3 September 2018

1 reference

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The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development.

3 September 2018

1 reference

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Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

3 September 2018

1 reference

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Splenic CD4+ T Cells Have a Distinct Transcriptional Response Six Hours after the Onset of Sepsis

3 September 2018

1 reference

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IL-12 Suppression During Experimental Endotoxin Tolerance: Dendritic Cell Loss and Macrophage Hyporesponsiveness

4 December 2018

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12 December 2020

LPS-Induced Upregulation of SHIP Is Essential for Endotoxin Tolerance

1 reference

12 December 2020

Monocyte intracellular cytokine production during human endotoxaemia with or without a second in vitro LPS challenge: effect of RWJ-67657, a p38 MAP-kinase inhibitor, on LPS-hyporesponsiveness

1 reference

12 December 2020

Endotoxin Tolerance Represents a Distinctive State of Alternative Polarization (M2) in Human Mononuclear Cells

1 reference

12 December 2020

LPS tolerance in human endothelial cells: reduced PMN adhesion, E-selectin expression, and NF-kappaB mobilization

1 reference

12 December 2020

American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis

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12 December 2020

Gene-specific control of inflammation by TLR-induced chromatin modifications

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12 December 2020

The role of macrophages in LPS-induced lethality and tissue injury

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12 December 2020

Identifiers

DOI

10.1172/JCI83404

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27427981%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27427981%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference