Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice (Q37143384)

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scientific article published on 16 March 2009

Language	Label	Description	Also known as
English	Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice	scientific article published on 16 March 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

0 references

apoptotic process

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atherosclerosis

1 reference

based on heuristic

inferred from title

Dorien M Schrijvers

object named as

Dorien M Schrijvers

5

0 references

object named as

Yibin Wang

2

0 references

Tracie A. Seimon

1

object named as

Tracie A Seimon

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

author name string

Seongah Han

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Takafumi Senokuchi

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

George Kuriakose

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Alan R Tall

7

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Ira A Tabas

8

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

language of work or name

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publication date

16 March 2009

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Europe PubMed Central

PMC publication ID

18 August 2017

Journal of Clinical Investigation

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Europe PubMed Central

PMC publication ID

18 August 2017

119

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

886-898

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Mechanisms and consequences of macrophage apoptosis in atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease

1 reference

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6 September 2017

High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

p38 pathway kinases as anti-inflammatory drug targets

1 reference

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6 September 2017

p38 MAPK in regulating cellular responses to ultraviolet radiation

1 reference

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6 September 2017

Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.

1 reference

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6 September 2017

Phagocytosis in atherosclerosis: Molecular mechanisms and implications for plaque progression and stability.

1 reference

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6 September 2017

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

1 reference

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6 September 2017

The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival

1 reference

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6 September 2017

Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy

1 reference

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6 September 2017

Identification of a tumour suppressor network opposing nuclear Akt function

1 reference

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6 September 2017

Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

Pathologic assessment of the vulnerable human coronary plaque

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1 reference

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6 September 2017

Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

New techniques for the evaluation of the vulnerable plaque.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

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6 September 2017

Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

6 September 2017

Distinct cellular functions of MK2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

14 September 2017

Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

14 September 2017

Serum-withdrawal-dependent apoptosis of hippocampal neuroblasts involves Ca++ release by endoplasmic reticulum and caspase-12 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

14 September 2017

Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

14 September 2017

Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

14 September 2017

Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and a

1 reference

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14 September 2017

Heat Shock Protein 27 Controls Apoptosis by Regulating Akt Activation

1 reference

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14 September 2017

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

1 reference

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29 September 2017

Insulin regulation of gene expression through the forkhead transcription factor Foxo1 (Fkhr) requires kinases distinct from Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

29 September 2017

Macrophages and atherosclerotic plaque stability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

29 September 2017

The unfolded protein response is an important regulator of inflammatory genes in endothelial cells

1 reference

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27 June 2018

Free cholesterol loading of macrophages induces apoptosis involving the fas pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

27 June 2018

Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

3 September 2018

Akt up- and down-regulation in response to endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

3 September 2018

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

3 September 2018

Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

3 September 2018

Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

3 September 2018

Elevated gadd153/chop expression and enhanced c-Jun N-terminal protein kinase activation sensitizes aged cells to ER stress

1 reference

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3 September 2018

Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells

1 reference

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3 September 2018

The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662559

3 September 2018

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

1 reference

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3 September 2018

RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice.

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3 September 2018

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3 September 2018

Systemic Deficiency of the MAP Kinase–Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice

1 reference

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4 December 2018

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287091

12 December 2020

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Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287091

12 December 2020

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Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions. A cytochemical and ultrastructural study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287091

12 December 2020

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The Phenotype of Inflammatory Macrophages Is Stimulus Dependent: Implications for the Nature of the Inflammatory Response

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287091

12 December 2020

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Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287091

12 December 2020

based on heuristic

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Apoptosis in atherogenesis: implications for plaque destabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19287091

12 December 2020

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p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of atherosclerosis: MRI assessment

1 reference

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based on heuristic

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Identifiers

10.1172/JCI37262

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

0 references

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