p38 pathway kinases as anti-inflammatory drug targets (Q36919718)

17 August 2017

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title

p38 pathway kinases as anti-inflammatory drug targets (English)

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17 August 2017

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J F Schindler

1

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17 August 2017

J B Monahan

series ordinal

2

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17 August 2017

W G Smith

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 September 2007

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Journal of Dental Research

17 August 2017

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17 August 2017

86

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17 August 2017

9

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17 August 2017

800-811

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Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

17 August 2017

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https://api.crossref.org/works/10.1177%2F154405910708600902

Insulin signal transduction through protein kinase cascades.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Generation and characterization of p38beta (MAPK11) gene-targeted mice.

21 January 2018

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https://api.crossref.org/works/10.1177%2F154405910708600902

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Mechanism of p38 MAP kinase activation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Feedback control of the protein kinase TAK1 by SAPK2a/p38

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Mechanisms of regulating the Raf kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Biological therapies for inflammatory bowel disease: research drives clinics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Signal transduction by the JNK group of MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

A synthetic inhibitor of the mitogen-activated protein kinase cascade

21 January 2018

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https://api.crossref.org/works/10.1177%2F154405910708600902

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1177%2F154405910708600902

Molecular determinants that mediate selective activation of p38 MAP kinase isoforms

21 January 2018

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https://api.crossref.org/works/10.1177%2F154405910708600902

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

21 January 2018

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https://api.crossref.org/works/10.1177%2F154405910708600902

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

MAPKAP kinases - MKs - two's company, three's a crowd

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Feedback control of MKP-1 expression by p38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Structure-function studies of p38 mitogen-activated protein kinase. Loop 12 influences substrate specificity and autophosphorylation, but not upstream kinase selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Multiple activation mechanisms of p38alpha mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Cytokine-driven cell cycling is mediated through Cdc25A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Transcriptional and post-transcriptional control of gene expression in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38alpha protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Targeting JNK for therapeutic benefit: from junk to gold?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Inhibition of p38 mitogen-activated protein kinase prevents inflammatory bone destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

p38 MAPK signaling in oral-related diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Examination of the kinetic mechanism of mitogen-activated protein kinase activated protein kinase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

AP-1 as a regulator of cell life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Circulating monocytes in patients with acute coronary syndromes lack sufficient interleukin-10 production after lipopolysaccharide stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Glia: novel counter-regulators of opioid analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Molecular basis of MAPK-activated protein kinase 2:p38 assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Crystal structure of p38 mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

RSK and MSK in MAP kinase signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154405910708600902

10.1177/154405910708600902

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference