The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells. (Q37143515)

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5 March 2020

title

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells (English)

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5 March 2020

6

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author name string

Elisa Franzolin

1

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5 March 2020

Giovanna Pontarin

2

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5 March 2020

Chiara Rampazzo

3

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5 March 2020

Cristina Miazzi

4

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5 March 2020

Paola Ferraro

5

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5 March 2020

Peter Reichard

7

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5 March 2020

Vera Bianchi

8

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5 March 2020

language of work or name

English

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publication date

15 July 2013

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Proceedings of the National Academy of Sciences of the United States of America

5 March 2020

published in

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volume

110

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issue

35

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5 March 2020

page(s)

14272-14277

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Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.

5 March 2020

cites work

1 reference

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The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation

6 September 2017

1 reference

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Promoter methylation regulates SAMHD1 gene expression in human CD4+ T cells

6 September 2017

1 reference

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Telomere length homeostasis responds to changes in intracellular dNTP pools

6 September 2017

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Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells

6 September 2017

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Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair

6 September 2017

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Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages

6 September 2017

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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

6 September 2017

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Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

6 September 2017

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Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli

6 September 2017

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Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase

6 September 2017

1 reference

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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

6 September 2017

1 reference

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Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-Substrate Complex

6 September 2017

1 reference

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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

6 September 2017

1 reference

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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

6 September 2017

1 reference

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Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

6 September 2017

1 reference

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Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances

6 September 2017

1 reference

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Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

6 September 2017

1 reference

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Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae.

6 September 2017

1 reference

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Ribonucleotide reductases

6 September 2017

1 reference

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6 September 2017

The many faces of SAM

1 reference

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Enzymatic cleavage of deoxyguanosine triphosphate to deoxyguanosine and tripolyphosphate

6 September 2017

1 reference

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Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis

6 September 2017

1 reference

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Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells

6 September 2017

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Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder

6 September 2017

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The HD domain defines a new superfamily of metal-dependent phosphohydrolases

6 September 2017

1 reference

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Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools

6 September 2017

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Human adenosine deaminase. cDNA and complete primary amino acid sequence

6 September 2017

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Interactions between deoxyribonucleotide and DNA synthesis

6 September 2017

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Purine nucleoside phosphorylase deficiency

6 September 2017

1 reference

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Characterization of a mutator gene in Chinese hamster ovary cells

6 September 2017

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Knockdown of cytosolic 5'-nucleotidase II (cN-II) reveals that its activity is essential for survival in astrocytoma cells.

6 September 2017

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p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.

14 September 2017

1 reference

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Mitochondrial deoxyribonucleotides, pool sizes, synthesis, and regulation

14 September 2017

1 reference

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Cytosolic high K(m) 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism

14 September 2017

1 reference

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MCB elements and the regulation of DNA replication genes in yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3761606

Immunocytochemical evidence for the cytoplasmic localization and differential expression during the cell cycle of the M1 and M2 subunits of mammalian ribonucleotide reductase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3761606

Deoxyribonucleotide metabolism in cycling and resting human fibroblasts with a missense mutation in p53R2, a subunit of ribonucleotide reductase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3761606

Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3761606

Localization of ribonucleotide reductase in mammalian cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3761606

Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3761606

Biochemical characterization of TT1383 from Thermus thermophilus identifies a novel dNTP triphosphohydrolase activity stimulated by dATP and dTTP.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3761606

HIV Interplay with SAMHD1

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1312033110

21 January 2018

DNA replication fidelity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23858451

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1312033110

1 reference

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5 March 2020

0 references

1 reference

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5 March 2020

PubMed publication ID

23858451

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858451%20AND%20SRC:MED&resulttype=core&format=json