Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype (Q35760007)

10 August 2017

title

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype (English)

1 reference

10 August 2017

1 reference

Tina L Sing

4

0 references

Jessica A. Vaisica

Jessica A Vaisica

7

0 references

Andrei Chabes

Andrei Chabes

11

0 references

Grant W Brown

Grant W Brown

13

0 references

Katsuhiko Shirahige

12

Katsuhiko Shirahige

1 reference

10 August 2017

Marta B Davidson

1

1 reference

10 August 2017

Yuki Katou

2

1 reference

10 August 2017

Andrea Keszthelyi

3

1 reference

10 August 2017

Tian Xia

5

1 reference

10 August 2017

Jiongwen Ou

6

1 reference

10 August 2017

Neroshan Thevakumaran

8

1 reference

10 August 2017

Lisette Marjavaara

9

1 reference

10 August 2017

Chad L Myers

10

1 reference

10 August 2017

language of work or name

English

0 references

publication date

10 January 2012

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10 August 2017

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10 August 2017

volume

31

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10 August 2017

issue

4

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10 August 2017

page(s)

895-907

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The distribution of the numbers of mutants in bacterial populations

10 August 2017

cites work

1 reference

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dNTP pools determine fork progression and origin usage under replication stress

2 October 2017

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Putting genetic interactions in context through a global modular decomposition

2 October 2017

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Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance.

2 October 2017

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Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools

2 October 2017

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Nucleotide deficiency promotes genomic instability in early stages of cancer development

2 October 2017

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Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

2 October 2017

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Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.

2 October 2017

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Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levels

2 October 2017

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DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity

2 October 2017

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A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.

2 October 2017

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Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response

2 October 2017

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2 October 2017

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Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase

2 October 2017

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Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit

2 October 2017

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The temporal program of chromosome replication: genomewide replication in clb5{Delta} Saccharomyces cerevisiae

2 October 2017

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A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.

2 October 2017

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Genetic instability is not a requirement for tumor development

2 October 2017

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Cancers exhibit a mutator phenotype: clinical implications

2 October 2017

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The N- and C-termini of Elg1 contribute to the maintenance of genome stability

2 October 2017

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Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms

2 October 2017

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Differential regulation of the cellular response to DNA double-strand breaks in G1.

2 October 2017

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An oncogene-induced DNA damage model for cancer development

2 October 2017

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Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination

2 October 2017

1 reference

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Ninety-six haploid yeast strains with individual disruptions of open reading frames between YOR097C and YOR192C, constructed for the Saccharomyces genome deletion project, have an additional mutation in the mismatch repair gene MSH3

2 October 2017

1 reference

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A high-resolution atlas of nucleosome occupancy in yeast

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Replication in hydroxyurea: it's a matter of time

2 October 2017

1 reference

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PCNA, the maestro of the replication fork

2 October 2017

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Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae.

2 October 2017

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Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length

2 October 2017

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

2 October 2017

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

2 October 2017

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OriDB: a DNA replication origin database

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Establishment of sister chromatid cohesion at the S. cerevisiae replication fork

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

2 October 2017

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Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.

2 October 2017

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Generation of mutator mutants during carcinogenesis

2 October 2017

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DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Hydroxyurea Arrests DNA Replication by a Mechanism That Preserves Basal dNTP Pools

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations

2 October 2017

1 reference

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S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Elg1 forms an alternative RFC complex important for DNA replication and genome integrity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways

2 October 2017

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Maintenance of genome stability in Saccharomyces cerevisiae

2 October 2017

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Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathway

2 October 2017

1 reference

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Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae

2 October 2017

1 reference

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The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.

2 October 2017

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Effects of biological DNA precursor pool asymmetry upon accuracy of DNA replication in vitro

2 October 2017

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Systematic genetic analysis with ordered arrays of yeast deletion mutants

2 October 2017

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Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion

2 October 2017

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A role for Saccharomyces cerevisiae histone H2A in DNA repair.

2 October 2017

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PCNA connects DNA replication to epigenetic inheritance in yeast.

2 October 2017

1 reference

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Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit

2 October 2017

1 reference

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

2 October 2017

1 reference

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Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

2 October 2017

1 reference

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A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools

2 October 2017

1 reference

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The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor

2 October 2017

1 reference

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Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications

2 October 2017

1 reference

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Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Role of the casein kinase I isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae

2 October 2017

1 reference

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Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways

2 October 2017

1 reference

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DNA damage and cell cycle regulation of ribonucleotide reductase

2 October 2017

1 reference

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Cell cycle regulated transcription in yeast.

2 October 2017

1 reference

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Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate

2 October 2017

1 reference

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Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability

2 October 2017

1 reference

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Interactions between deoxyribonucleotide and DNA synthesis

2 October 2017

1 reference

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DNA damage induction of ribonucleotide reductase

2 October 2017

1 reference

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The DNA damage-inducible gene DIN1 of Saccharomyces cerevisiae encodes a regulatory subunit of ribonucleotide reductase and is identical to RNR3.

2 October 2017

1 reference

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Mutator phenotype may be required for multistage carcinogenesis

2 October 2017

1 reference

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Getting started with yeast

2 October 2017

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Modulation of mutagenesis by deoxyribonucleotide levels

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae

2 October 2017

1 reference

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Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells

12 July 2018

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Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.

12 July 2018

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DUN1 encodes a protein kinase that controls the DNA damage response in yeast

12 July 2018

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Inhibition of ribonucleoside diphosphate reductase by hydroxyurea

12 July 2018

1 reference

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Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase

12 July 2018

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Comparative genome hybridization on tiling microarrays to detect aneuploidies in yeast

21 January 2018

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Genomic approach for the understanding of dynamic aspect of chromosome behavior.

21 January 2018

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Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase

21 January 2018

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A common telomeric gene silencing assay is affected by nucleotide metabolism

21 January 2018

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Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage.

21 January 2018

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Ctf4 coordinates the progression of helicase and DNA polymerase alpha.

21 January 2018

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Ribonucleotide reductase and mitochondrial DNA synthesis

21 January 2018

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Stimulation of mutagenesis by proportional deoxyribonucleoside triphosphate accumulation in Escherichia coli

21 January 2018

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Flexible filaments in a flowing soap film as a model for one-dimensional flags in a two-dimensional wind.

21 January 2018

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A stable and sensitive genotoxic testing system based on DNA damage induced gene expression in Saccharomyces cerevisiae

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280564

The synthetic genetic interaction spectrum of essential genes

25 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.485

21 January 2018

Identifiers

DOI

10.1038/EMBOJ.2011.485

1 reference

10 August 2017

1 reference

10 August 2017

1 reference