The cellular source and target of IL-21 in K/BxN autoimmune arthritis (Q37161317)

18 August 2017

The cellular source and target of IL-21 in K/BxN autoimmune arthritis (English)

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18 August 2017

Katharine E Block

1

1 reference

18 August 2017

Haochu Huang

series ordinal

2

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18 August 2017

language of work or name

English

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publication date

19 August 2013

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18 August 2017

Journal of Immunology

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18 August 2017

191

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18 August 2017

6

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18 August 2017

2948-2955

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describes a project that uses

18 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3769479/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms

6 September 2017

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IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice

6 September 2017

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6 September 2017

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Characterization of the KRN cell transfer model of rheumatoid arthritis (KRN-CTM), a chronic yet synchronized version of the K/BxN mouse

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

6 September 2017

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IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

6 September 2017

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A polymorphism within IL21R confers risk for systemic lupus erythematosus

6 September 2017

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The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

6 September 2017

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Follicular helper T cells are required for systemic autoimmunity

6 September 2017

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A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

6 September 2017

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ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

6 September 2017

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IL-21 signaling is critical for the development of type I diabetes in the NOD mouse

6 September 2017

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The role of IL-21 in regulating B-cell function in health and disease.

6 September 2017

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A fundamental role for interleukin-21 in the generation of T follicular helper cells

6 September 2017

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

6 September 2017

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Development and characterization of IL-21-producing CD4+ T cells

6 September 2017

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6 September 2017

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Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice

6 September 2017

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6 September 2017

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

6 September 2017

1 reference

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

6 September 2017

1 reference

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

6 September 2017

1 reference

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Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

6 September 2017

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An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells

6 September 2017

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A critical role for IL-21 in regulating immunoglobulin production

6 September 2017

1 reference

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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

6 September 2017

1 reference

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From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins

6 September 2017

1 reference

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Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes

6 September 2017

1 reference

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Vaccine adjuvants alter TCR-based selection thresholds.

6 September 2017

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ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6

14 September 2017

1 reference

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IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

27 June 2018

1 reference

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A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769479

Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769479

Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769479

Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme

4 December 2018

1 reference

12 December 2020

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

1 reference

12 December 2020

Organ-specific disease provoked by systemic autoimmunity

1 reference

12 December 2020

Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

1 reference

12 December 2020

Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1301173

1 reference

18 August 2017

1 reference

18 August 2017

1 reference