Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting. (Q37162837)

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17 January 2020

title

Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting (English)

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17 January 2020

5

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17 January 2020

Daniel Russ

6

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17 January 2020

Dereje D Jima

7

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17 January 2020

Amrie C Grammer

9

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17 January 2020

author name string

Nancy S Longo

1

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17 January 2020

Patricia L Lugar

2

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17 January 2020

Sule Yavuz

3

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17 January 2020

Wen Zhang

4

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17 January 2020

Sandeep S Dave

8

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17 January 2020

Peter E Lipsky

10

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17 January 2020

language of work or name

English

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publication date

20 November 2008

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17 January 2020

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17 January 2020

volume

113

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17 January 2020

issue

16

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17 January 2020

page(s)

3706-3715

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Characterization of Ig gene somatic hypermutation in the absence of activation-induced cytidine deaminase

17 January 2020

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Human IgM+CD27+ B cells: memory B cells or "memory" B cells?

6 September 2017

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Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.

6 September 2017

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Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells

6 September 2017

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DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse

6 September 2017

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DNA repair in antibody somatic hypermutation

6 September 2017

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SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

6 September 2017

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ABCB1 transporter discriminates human resting naive B cells from cycling transitional and memory B cells

6 September 2017

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Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells

6 September 2017

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B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil

6 September 2017

1 reference

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Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification

6 September 2017

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MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes

6 September 2017

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Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells

6 September 2017

1 reference

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Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled

6 September 2017

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A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination

6 September 2017

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Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions

6 September 2017

1 reference

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Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

6 September 2017

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Exploration, normalization, and summaries of high density oligonucleotide array probe level data

6 September 2017

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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

6 September 2017

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The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant

6 September 2017

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

6 September 2017

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

6 September 2017

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CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans

6 September 2017

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

6 September 2017

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

6 September 2017

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Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

6 September 2017

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

6 September 2017

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Defects of T-cell effector function and post-thymic maturation in X-linked hyper-IgM syndrome

6 September 2017

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6 September 2017

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Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

6 September 2017

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Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

6 September 2017

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Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells

6 September 2017

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6 September 2017

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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers

6 September 2017

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Expansion, selection and mutation of antigen-specific B cells in germinal centers

6 September 2017

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gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory

6 September 2017

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Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6.

14 September 2017

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CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10.

14 September 2017

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Absence of IgD-CD27(+) memory B cell population in X-linked hyper-IgM syndrome

14 September 2017

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Defective expression of CD40 ligand on T cells causes "X-linked immunodeficiency with hyper-IgM (HIGM1)".

14 September 2017

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The CD40 ligand expressed by human B cells costimulates B cell responses

14 September 2017

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IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.

29 September 2017

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Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

27 June 2018

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

27 June 2018

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Evolution of somatic hypermutation and gene conversion in adaptive immunity

27 June 2018

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Yates's correction for continuity and the analysis of 2 x 2 contingency tables.

27 June 2018

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Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

27 June 2018

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Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers.

27 June 2018

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Why do B cells mutate their immunoglobulin receptors?

3 September 2018

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Molecular diagnosis of Burkitt's lymphoma

3 September 2018

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3 September 2018

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Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells

4 December 2018

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AID expression identifies interfollicular large B cells as putative precursors of mature B-cell malignancies.

3 September 2018

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Human splenic marginal zone B cells lack expression of activation-induced cytidine deaminase

3 September 2018

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Characterization of the human Ig heavy chain antigen binding complementarity determining region 3 using a newly developed software algorithm, JOINSOLVER.

3 September 2018

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Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

3 September 2018

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Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

3 September 2018

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Targeting and selection of mutations in human Vlambda rearrangements.

3 September 2018

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Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands.

3 September 2018

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Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.

3 September 2018

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Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.

3 September 2018

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CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome

3 September 2018

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Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction.

3 September 2018

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Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

3 September 2018

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12 December 2020

Delineation of selective influences shaping the mutated expressed human Ig heavy chain repertoire

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The human CD77- B cell population represents a heterogeneous subset of cells comprising centroblasts, centrocytes, and plasmablasts, prompting phenotypical revision

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The influence of CD40-CD154 interactions on the expressed human V(H) repertoire: analysis of V(H) genes expressed by individual B cells of a patient with X-linked hyper-IgM syndrome

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Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene

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CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

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Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human VHDJH rearrangements

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Molecular mechanisms and selection influence the generation of the human V lambda J lambda repertoire

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A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus

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Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL

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Strand-biased spreading of mutations during somatic hypermutation

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Somatic hypermutation of VkappaJkappa rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs

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CD27: a memory B-cell marker

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10.1182/BLOOD-2008-10-183632

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17 January 2020

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