Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. (Q37175962)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19390090%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus (English)

1 reference

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26 January 2020

3

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26 January 2020

author name string

Hainan Chen

1

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26 January 2020

Xueying Gu

2

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26 January 2020

Rita Bottino

4

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26 January 2020

Juan L Contreras

5

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26 January 2020

Alexander Tarakhovsky

6

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26 January 2020

Seung K Kim

7

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26 January 2020

language of work or name

1 reference

1 April 2009

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26 January 2020

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26 January 2020

volume

23

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26 January 2020

issue

8

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26 January 2020

page(s)

975-985

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Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation

26 January 2020

cites work

1 reference

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Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

6 September 2017

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Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.

6 September 2017

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Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus

6 September 2017

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

6 September 2017

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6 September 2017

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6 September 2017

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The regulation of INK4/ARF in cancer and aging

6 September 2017

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Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function

6 September 2017

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p16INK4a induces an age-dependent decline in islet regenerative potential

6 September 2017

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Intrinsic regulators of pancreatic beta-cell proliferation

6 September 2017

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Molecular control of cell cycle progression in the pancreatic beta-cell

6 September 2017

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The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

6 September 2017

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Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

6 September 2017

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Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth

6 September 2017

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Ink4a/Arf expression is a biomarker of aging

6 September 2017

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Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

6 September 2017

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Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

6 September 2017

1 reference

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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

6 September 2017

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

6 September 2017

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Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

6 September 2017

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

6 September 2017

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6 September 2017

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14 September 2017

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27 June 2018

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Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

27 June 2018

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3 September 2018

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3 September 2018

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Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

3 September 2018

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Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes

3 September 2018

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Role of the INK4a locus in tumor suppression and cell mortality.

3 September 2018

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Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19390090

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19390090

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19390090

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.1742509

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19390090%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19390090%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference