PTEN: a default gate-keeping tumor suppressor with a versatile tail (Q37216319)

19 August 2017

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title

PTEN: a default gate-keeping tumor suppressor with a versatile tail (English)

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19 August 2017

Xinjiang Wang

1

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PubMed ID

18626510

19 August 2017

Xuejun Jiang

series ordinal

2

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19 August 2017

1 August 2008

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19 August 2017

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19 August 2017

18

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19 August 2017

8

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19 August 2017

807-816

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https://scigraph.springernature.com/pub.10.1038/cr.2008.83

19 August 2017

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cites work

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

The biology and clinical relevance of the PTEN tumor suppressor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Germline mutations in PTEN are present in Bannayan-Zonana syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Essential role for nuclear PTEN in maintaining chromosomal integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Epigenetic PTEN silencing in malignant melanomas without PTEN mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Regulation of PTEN transcription by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Regulation of PTEN by Rho small GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Phosphorylation of the PTEN tail regulates protein stability and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

PTEN is destabilized by phosphorylation on Thr366.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

The redox regulation of PI 3-kinase-dependent signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

21 January 2018

New insights into PTEN.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Regulation of the PTEN phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Pten dose dictates cancer progression in the prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Ubiquitination regulates PTEN nuclear import and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

The nuclear affairs of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

PTEN: life as a tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

The multiple roles of PTEN in tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Inhibition of neuronal phenotype by PTEN in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Lack of PTEN sequesters CHK1 and initiates genetic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

PTEN: from pathology to biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Mutations of the human PTEN gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

PTEN: one gene, many syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Genetic pathways to primary and secondary glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Mouse models dissect the role of p53 in cancer and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Decision making by p53: life, death and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

p53 ubiquitination: Mdm2 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Mechanistic insights into maintenance of high p53 acetylation by PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

PTEN Autoregulates Its Expression by Stabilization of p53 in a Phosphatase-Independent Manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

Epigenetic silencing of the PTEN gene in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

7 January 2021

A role for nuclear PTEN in neuronal differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

7 January 2021

Redox regulation of PTEN by S-nitrosothiols

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

7 January 2021

Nuclear PTEN: a tale of many tails

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

7 January 2021

Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

7 January 2021

Gatekeeper for endometrium: the PTEN tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.83

7 January 2021

Identifiers

DOI

10.1038/CR.2008.83

1 reference

PubMed ID

18626510

Dimensions Publication ID

19 August 2017

0 references

1 reference

PubMed ID

18626510