Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2 (Q37217028)

19 August 2017

Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2 (English)

1 reference

19 August 2017

0 references

Haichao Wang

6

0 references

Timothy Billiar

5

object named as

Timothy Billiar

1 reference

19 August 2017

Zhaoxia Zhang

1

1 reference

19 August 2017

Wenjun Deng

2

1 reference

19 August 2017

Rui Kang

3

1 reference

19 August 2017

Min Xie

4

1 reference

19 August 2017

Lizhi Cao

7

1 reference

19 August 2017

Daolin Tang

8

1 reference

19 August 2017

language of work or name

English

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publication date

9 March 2016

1 reference

19 August 2017

1 reference

Creative Commons Attribution 4.0 International

19 August 2017

start time

1 January 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.2119/molmed.2015.00250

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cites work

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Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages

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PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

6 September 2017

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Inhibition of nuclear Nox4 activity by plumbagin: effect on proliferative capacity in human amniotic stem cells

6 September 2017

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Plumbagin inhibits LPS-induced inflammation through the inactivation of the nuclear factor-kappa B and mitogen activated protein kinase signaling pathways in RAW 264.7 cells

6 September 2017

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Plumbagin, a vitamin K3 analogue, abrogates lipopolysaccharide-induced oxidative stress, inflammation and endotoxic shock via NF-κB suppression

6 September 2017

1 reference

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Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating trans

6 September 2017

1 reference

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Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling

6 September 2017

1 reference

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Hypoxia downregulates PPARγ via an ERK1/2-NF-κB-Nox4-dependent mechanism in human pulmonary artery smooth muscle cells

6 September 2017

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

6 September 2017

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Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in BALB/c mice

6 September 2017

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Metabolism of inflammation limited by AMPK and pseudo-starvation

6 September 2017

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EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis

6 September 2017

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Perspectives on medicinal properties of plumbagin and its analogs

6 September 2017

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Metabolic checkpoints in activated T cells

6 September 2017

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The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation

6 September 2017

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6 September 2017

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Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

6 September 2017

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NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium

6 September 2017

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HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

6 September 2017

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High-mobility group box 1 is essential for mitochondrial quality control

6 September 2017

1 reference

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Cecal ligation puncture procedure.

6 September 2017

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HMGB1 is a therapeutic target for sterile inflammation and infection

6 September 2017

1 reference

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Redox regulation of Nox proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

Plumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiols

6 September 2017

1 reference

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Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

6 September 2017

1 reference

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Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

Understanding the Warburg effect: the metabolic requirements of cell proliferation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

Immunodesign of experimental sepsis by cecal ligation and puncture

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

HMG-1 as a late mediator of endotoxin lethality in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFκB signaling pathways

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2).

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

Bone Marrow-Derived Macrophages (BMM): Isolation and Applications

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004715

First observations on the topical use of Primin, Plumbagin and Maytenin in patients with skin cancer

4 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26982513

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2119/MOLMED.2015.00250

1 reference

Dimensions Publication ID

19 August 2017

0 references

1 reference

19 August 2017

1 reference