Signal transduction in transgenic mouse models of human breast cancer--implications for human breast cancer (Q37225436)

19 August 2017

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title

Signal transduction in transgenic mouse models of human breast cancer--implications for human breast cancer (English)

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19 August 2017

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Richard Marcotte

1

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PubMed ID

18651209

19 August 2017

William J Muller

series ordinal

2

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19 August 2017

24 July 2008

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Journal of Mammary Gland Biology and Neoplasia

19 August 2017

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19 August 2017

13

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19 August 2017

3

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19 August 2017

323-335

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https://scigraph.springernature.com/pub.10.1007/s10911-008-9087-3

19 August 2017

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Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice

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Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity

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Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation

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ShcA signalling is essential for tumour progression in mouse models of human breast cancer

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12 December 2020

Long-term exposure to elevated levels of circulating TIMP-1 but not mammary TIMP-1 suppresses growth of mammary carcinomas in transgenic mice.

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12 December 2020

Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice

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12 December 2020

Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis

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12 December 2020

The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter

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12 December 2020

Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion

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12 December 2020

Duality of p27Kip1 function in tumorigenesis

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12 December 2020

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer

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12 December 2020

Involvement of insulin receptor substrate 2 in mammary tumor metastasis

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12 December 2020

Cyclin D1, EMS1 and 11q13 amplification in breast cancer

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12 December 2020

The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

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12 December 2020

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

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12 December 2020

p53 mutations in breast cancer

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12 December 2020

The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

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12 December 2020

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

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12 December 2020

Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer

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12 December 2020

Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis

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12 December 2020

Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation

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12 December 2020

CDK inhibitors: cell cycle regulators and beyond

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12 December 2020

Polyoma virus middle T antigen and its role in identifying cancer-related molecules

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Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

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12 December 2020

Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breast

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12 December 2020

A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas

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12 December 2020

The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression to carcinoma

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12 December 2020

Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression

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12 December 2020

ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells

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12 December 2020

Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

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12 December 2020

The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling

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12 December 2020

p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling

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12 December 2020

Tumour dormancy in breast cancer: an update

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12 December 2020

Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice.

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12 December 2020

Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice

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12 December 2020

Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

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12 December 2020

Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4

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12 December 2020

Gene expression profiling of neu-induced mammary tumors from transgenic mice reveals genetic and morphological similarities to ErbB2-expressing human breast cancers

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12 December 2020

Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli

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12 December 2020

Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma

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12 December 2020

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

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12 December 2020

p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis.

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12 December 2020

Cyclin D1 and breast cancer

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12 December 2020

Cell transformation by the middle T-antigen of polyoma virus

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12 December 2020

Breast cancer in 2007: incidence, risk assessment, and risk reduction strategies

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12 December 2020

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

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12 December 2020

Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors

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12 December 2020

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation

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12 December 2020

Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

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12 December 2020

Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland

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12 December 2020

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

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12 December 2020

A novel splice variant of HER2 with increased transformation activity

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12 December 2020

Mammary tumor suppression by transforming growth factor beta 1 transgene expression

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12 December 2020

The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis

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12 December 2020

The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis

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12 December 2020

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

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12 December 2020

Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling

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12 December 2020

EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion

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12 December 2020

A role for the scaffolding adapter GAB2 in breast cancer

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12 December 2020

Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice

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12 December 2020

The predictive value of HER2 in breast cancer

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12 December 2020

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

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12 December 2020

New functions for the matrix metalloproteinases in cancer progression

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12 December 2020

Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

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12 December 2020

Eph-ephrin bidirectional signaling in physiology and disease

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12 December 2020

Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

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12 December 2020

The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy.

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12 December 2020

The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.

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12 December 2020

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis

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12 December 2020

Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis.

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12 December 2020

Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis

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12 December 2020

The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation.

1 reference

12 December 2020

Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor

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12 December 2020

Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.

1 reference

12 December 2020

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.

1 reference

12 December 2020

Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis.

1 reference

12 December 2020

Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo

1 reference

12 December 2020

The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting

1 reference

12 December 2020

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice

1 reference

12 December 2020

Akt1 governs breast cancer progression in vivo

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12 December 2020

Specific protection against breast cancers by cyclin D1 ablation

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12 December 2020

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis

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12 December 2020

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1 reference

12 December 2020

Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer

1 reference

12 December 2020

Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu

1 reference

12 December 2020

Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance

1 reference

12 December 2020

Induction of mammary gland hyperplasia in transgenic mice over-expressing human Cdc25B.

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12 December 2020

Overexpression of the protein tyrosine phosphatase PTP1B in human breast cancer: association with p185c-erbB-2 protein expression

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12 December 2020

The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer

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12 December 2020

Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer?

1 reference

12 December 2020

Models, mechanisms and clinical evidence for cancer dormancy

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12 December 2020

Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction.

1 reference

12 December 2020

Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice

1 reference

12 December 2020

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies

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12 December 2020

The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis

1 reference

12 December 2020

Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas

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12 December 2020

IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells

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12 December 2020

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner

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12 December 2020

Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice

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12 December 2020

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

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12 December 2020

Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted

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12 December 2020

MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease

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12 December 2020

The insulin-like growth factor 1 receptor in cancer: old focus, new future

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12 December 2020

The transcriptional repressor Snail promotes mammary tumor recurrence

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12 December 2020

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene

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12 December 2020

MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways

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12 December 2020

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

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12 December 2020

Role of Gab2 in mammary tumorigenesis and metastasis.

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12 December 2020

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12 December 2020

Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

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12 December 2020

A new model for ductal carcinoma in situ suggests strategies for treatment

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12 December 2020

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

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12 December 2020

The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity

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12 December 2020

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

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12 December 2020

10.1007/S10911-008-9087-3

Identifiers

DOI

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19 August 2017

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PubMed ID

18651209