Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. (Q37246230)

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25 January 2020

title

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates (English)

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25 January 2020

1

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25 January 2020

Travis H Stracker

2

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25 January 2020

John Petrini

4

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25 January 2020

author name string

Annalee Baker

3

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25 January 2020

David B Roth

5

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25 January 2020

publication date

1 April 2009

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25 January 2020

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25 January 2020

volume

34

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25 January 2020

issue

1

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25 January 2020

page(s)

13-25

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MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

25 January 2020

cites work

1 reference

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Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability

6 September 2017

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Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation

6 September 2017

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Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair

6 September 2017

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The endless tale of non-homologous end-joining

6 September 2017

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Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

6 September 2017

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Human CtIP promotes DNA end resection

6 September 2017

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IgH class switching and translocations use a robust non-classical end-joining pathway

6 September 2017

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Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.

6 September 2017

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Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining

6 September 2017

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Defective signal joint recombination in fanconi anemia fibroblasts reveals a role for Rad50 in V(D)J recombination

6 September 2017

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DNA-PK autophosphorylation facilitates Artemis endonuclease activity

6 September 2017

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ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

6 September 2017

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The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

6 September 2017

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Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells.

6 September 2017

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Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

6 September 2017

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Restraining the V(D)J recombinase

6 September 2017

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Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

6 September 2017

1 reference

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Cancer predisposition and hematopoietic failure in Rad50(S/S) mice

6 September 2017

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The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

6 September 2017

1 reference

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A murine model of Nijmegen breakage syndrome

6 September 2017

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

6 September 2017

1 reference

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Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome

6 September 2017

1 reference

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Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

6 September 2017

1 reference

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A mechanistic basis for Mre11-directed DNA joining at microhomologies

6 September 2017

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Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group

6 September 2017

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

6 September 2017

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Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

6 September 2017

1 reference

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DNA hairpin opening mediated by the RAG1 and RAG2 proteins

6 September 2017

1 reference

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Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

6 September 2017

1 reference

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Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation

6 September 2017

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Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11.

6 September 2017

1 reference

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Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

A severe combined immunodeficiency mutation in the mouse

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Methods for studying the cellular response to DNA damage: influence of the Mre11 complex on chromosome metabolism.

6 September 2017

1 reference

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Targeted disruption of the Artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

V(D)J rearrangement in Nijmegen breakage syndrome

28 September 2017

1 reference

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Formation and resolution of double-strand break intermediates in V(D)J rearrangement

28 September 2017

1 reference

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Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae

26 June 2018

1 reference

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RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704125

Rag mutations reveal robust alternative end joining

3 September 2018

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12 December 2020

Novel strand exchanges in V(D)J recombination

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12 December 2020

T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination

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12 December 2020

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

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12 December 2020

p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes

1 reference

12 December 2020

V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation

1 reference

12 December 2020

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

12 December 2020

The Rad50 hook domain is a critical determinant of Mre11 complex functions

1 reference

12 December 2020

The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements

1 reference

12 December 2020

10.1016/J.MOLCEL.2009.03.009

Identifiers

DOI

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25 January 2020

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25 January 2020

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