Targeted manipulation of apoptosis in cancer treatment (Q37257292)

19 August 2017

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title

Targeted manipulation of apoptosis in cancer treatment (English)

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19 August 2017

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Justin A Call

1

1 reference

PubMed ID

18760670

19 August 2017

S Gail Eckhardt

series ordinal

2

1 reference

PubMed ID

18760670

19 August 2017

D Ross Camidge

series ordinal

3

1 reference

19 August 2017

27 August 2008

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Lancet Oncology Commission

19 August 2017

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19 August 2017

9

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19 August 2017

1002-1011

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19 August 2017

10

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The role of apoptosis in cancer development and treatment response

19 August 2017

1 reference

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The Bcl-2 apoptotic switch in cancer development and therapy

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Portrait of a killer: the mitochondrial apoptosome emerges from the shadows

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

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Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function

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Intrinsic tumour suppression

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Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma

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Higher spontaneous apoptotic index in small cell compared with non-small cell lung carcinoma cell lines; lack of correlation with Bcl-2/Bax

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Antisense therapy in malignant diseases: status quo and quo vadis?

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Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group

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Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia

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Randomized phase II Study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103.

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Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis

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Structural biology of the Bcl-2 family of proteins

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Investigations on gossypol: past and present developments

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Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

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A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

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Discovery of a novel small molecule binding site of human survivin

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The proteasome: a worthwhile target for the treatment of solid tumours?

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The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells

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Survivin-dependent and -independent pathways and the induction of cancer cell death by tetra-O-methyl nordihydroguaiaretic acid

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Tetra-O-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression

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Regulation of survivin function by Hsp90

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Rational design of shepherdin, a novel anticancer agent.

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A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins.

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p53, the cellular gatekeeper for growth and division

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Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

1 reference

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Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis.

1 reference

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Death receptors and ligands in cervical carcinogenesis: an immunohistochemical study

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Targeted induction of apoptosis in cancer management: the emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents

1 reference

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HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo

1 reference

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Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1.

1 reference

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The promise of TRAIL--potential and risks of a novel anticancer therapy

1 reference

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Phase 1 and Pharmacokinetic Study of Lexatumumab in Patients with Advanced Cancers

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Safety and antitumor activity of recombinant soluble Apo2 ligand

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Targeting death receptors in cancer with Apo2L/TRAIL.

1 reference

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A Phase I trial of TNFerade biologic in patients with soft tissue sarcoma in the extremities

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TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a phase I study in patients with solid tumors

1 reference

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TRAIL death receptors and cancer therapeutics

1 reference

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Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

1 reference

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7 January 2021

10.1016/S1470-2045(08)70209-2

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

18760670