Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression (Q37259201)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24216479%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression (English)

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29 February 2020

2

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Kyoung Eun Lee

4

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29 February 2020

Ruliang Xu

5

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29 February 2020

Erika A Bach

8

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Mark R Philips

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29 February 2020

author name string

Helen Court

1

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29 February 2020

Michael Hackman

3

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29 February 2020

George Miller

6

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29 February 2020

Martin O Bergö

9

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29 February 2020

Dafna Bar-Sagi

7

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language of work or name

English

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publication date

1 November 2013

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Journal of Clinical Investigation

29 February 2020

published in

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29 February 2020

volume

123

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issue

11

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page(s)

4681-4694

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Regulating the regulator: post-translational modification of RAS

29 February 2020

cites work

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6 September 2017

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Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia

6 September 2017

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Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression

6 September 2017

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Rabs and their effectors: achieving specificity in membrane traffic

6 September 2017

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Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

6 September 2017

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Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras.

6 September 2017

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

6 September 2017

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6 September 2017

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A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice

6 September 2017

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Isoprenylcysteine carboxyl methyltransferase deficiency in mice

6 September 2017

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Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

6 September 2017

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Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

6 September 2017

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Chronic pancreatitis and other risk factors for pancreatic cancer

6 September 2017

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Generalized lacZ expression with the ROSA26 Cre reporter strain

6 September 2017

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

6 September 2017

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The pleiotropic function of Delta during postembryonic development of Drosophila melanogaster

6 September 2017

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6 September 2017

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ras oncogenes in human cancer: a review

6 September 2017

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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

6 September 2017

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Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells

6 September 2017

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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

14 September 2017

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Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue

14 September 2017

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Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

14 September 2017

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Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.

28 September 2017

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FKBP12 binds to acylated H-ras and promotes depalmitoylation

28 September 2017

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Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.

26 June 2018

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A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesion

26 June 2018

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The p21 ras C-terminus is required for transformation and membrane association

26 June 2018

1 reference

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Ras signalling on the endoplasmic reticulum and the Golgi

26 June 2018

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The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate.

3 September 2018

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Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis

3 September 2018

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12 December 2020

Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

1 reference

12 December 2020

Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems

1 reference

12 December 2020

Expression and activity of human prenylcysteine-directed carboxyl methyltransferase

1 reference

12 December 2020

Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter

1 reference

12 December 2020

Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs

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12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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12 December 2020

Identifiers

DOI

10.1172/JCI65764

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24216479%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24216479%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

24216479

1 reference