The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription (Q37273144)

19 August 2017

The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription (English)

1 reference

19 August 2017

Hong Ming Shen

1

1 reference

19 August 2017

Michael G Poirier

2

1 reference

19 August 2017

Michael J Allen

3

1 reference

19 August 2017

Justin North

4

1 reference

19 August 2017

Ratnesh Lal

5

1 reference

19 August 2017

Jonathan Widom

6

1 reference

19 August 2017

Ursula Storb

7

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19 August 2017

language of work or name

English

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publication date

20 April 2009

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Journal of Experimental Medicine

19 August 2017

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19 August 2017

206

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19 August 2017

5

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19 August 2017

1057-1071

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Spontaneous access to DNA target sites in folded chromatin fibers

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Dynamic regulation of nucleosome positioning in the human genome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

The role of chromatin during transcription

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

A genomic code for nucleosome positioning

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

An mRNA sequence derived from a programmed frameshifting signal decreases codon discrimination during translation initiation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

AID in somatic hypermutation and class switch recombination

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Measurement of histone-DNA interaction free energy in nucleosomes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

AID mediates hypermutation by deaminating single stranded DNA.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

The structure of DNA in the nucleosome core

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Transcription-dependent increase in multiple classes of base substitution mutations in Escherichia coli

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Promoter escape by RNA polymerase II

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Persistent interactions of core histone tails with nucleosomal DNA following acetylation and transcription factor binding

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Crystal structure of the nucleosome core particle at 2.8 A resolution

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Supercoiling of the DNA template during transcription

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Sequence motifs and free energies of selected natural and non-natural nucleosome positioning DNA sequences.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Escherichia coli translation initiation factor 3 discriminates the initiation codon in vivo

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Nucleosome remodeling induced by RNA polymerase II: loss of the H2A/H2B dimer during transcription.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715043

Sequence and position-dependence of the equilibrium accessibility of nucleosomal DNA target sites

3 September 2018

1 reference

12 December 2020

Lifetime of the histone octamer studied by continuous-flow quasielastic light scattering: test of a model for nucleosome transcription

1 reference

12 December 2020

A histone octamer can step around a transcribing polymerase without leaving the template

1 reference

12 December 2020

Mechanism of protein access to specific DNA sequences in chromatin: a dynamic equilibrium model for gene regulation

1 reference

12 December 2020

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

1 reference

12 December 2020

Nucleosome positions predicted through comparative genomics

1 reference

12 December 2020

DNA deaminases AID and APOBEC3G act processively on single-stranded DNA

1 reference

12 December 2020

Effects of Sequence and Structure on the Hypermutability of Immunoglobulin Genes

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20082678

1 reference

19 August 2017

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19 August 2017

1 reference