AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma (Q37274810)

19 August 2017

AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma (English)

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head and neck squamous cell carcinoma

19 August 2017

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author

John P Coan

6

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6 June 2020

Randall J Kimple

18

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6 June 2020

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Mark W Lingen

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6 June 2020

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Vassiliki Saloura

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6 June 2020

author name string

Toni M Brand

1

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6 June 2020

Mari Iida

2

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6 June 2020

Andrew P Stein

3

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6 June 2020

Kelsey L Corrigan

4

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Cara M Braverman

5

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6 June 2020

Hannah E Pearson

7

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Harsh Bahrar

8

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6 June 2020

Tyler L Fowler

9

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Bryan P Bednarz

10

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Sandeep Saha

11

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David Yang

12

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Parkash S Gill

13

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6 June 2020

Victoria M Villaflor

16

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Deric L Wheeler

19

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6 June 2020

Ravi Salgia

17

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6 June 2020

language of work or name

English

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publication date

12 March 2015

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19 August 2017

Clinical Cancer Research

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6 June 2020

volume

21

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issue

11

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page(s)

2601-2612

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HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis

6 June 2020

cites work

1 reference

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Axl kinase as a key target for oncology: focus on small molecule inhibitors

6 September 2017

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AXL mediates resistance to cetuximab therapy

6 September 2017

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Phase II study of cetuximab in combination with cisplatin and radiation in unresectable, locally advanced head and neck squamous cell carcinoma: Eastern cooperative oncology group trial E3303.

6 September 2017

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Axl receptor tyrosine kinase expression in breast cancer

6 September 2017

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A novel high-throughput irradiator for in vitro radiation sensitivity bioassays

6 September 2017

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AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer.

6 September 2017

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MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activation

6 September 2017

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Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib.

6 September 2017

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Human epidermal growth factor receptor 3 (HER3) blockade with U3-1287/AMG888 enhances the efficacy of radiation therapy in lung and head and neck carcinoma

6 September 2017

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The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells

6 September 2017

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Enhanced radiation sensitivity in HPV-positive head and neck cancer

6 September 2017

1 reference

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Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients

6 September 2017

1 reference

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AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells

6 September 2017

1 reference

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Development and characterization of HPV-positive and HPV-negative head and neck squamous cell carcinoma tumorgrafts

6 September 2017

1 reference

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An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

6 September 2017

1 reference

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Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer

6 September 2017

1 reference

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Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

6 September 2017

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Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor

6 September 2017

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The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.

6 September 2017

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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

6 September 2017

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Human papillomavirus predicts outcome in oropharyngeal cancer in patients treated primarily with surgery or radiation therapy

6 September 2017

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Optimal treatment for recurrent/metastatic head and neck cancer.

6 September 2017

1 reference

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Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma

6 September 2017

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AXL is an essential factor and therapeutic target for metastatic ovarian cancer

6 September 2017

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6 September 2017

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Evidence for mesenchymal-like sub-populations within squamous cell carcinomas possessing chemoresistance and phenotypic plasticity

6 September 2017

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Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma

6 September 2017

1 reference

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6 September 2017

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Defining molecular phenotypes of human papillomavirus-associated oropharyngeal squamous cell carcinoma: validation of three-class hypothesis

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model

6 September 2017

1 reference

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Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

6 September 2017

1 reference

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Expression of axl in lung adenocarcinoma and correlation with tumor progression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

Medical treatment in head and neck cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

Induction chemotherapy in locally advanced squamous cell cancer of the head and neck: evolution of the sequential treatment approach

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

ERBB receptor tyrosine kinases and cellular radiation responses

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

Evidence for a causal association between human papillomavirus and a subset of head and neck cancers

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

Activation of TYRO3/AXL tyrosine kinase receptors in thyroid cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

Nuclear EGFR contributes to acquired resistance to cetuximab

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

Epidermal growth factor receptor cooperates with Src family kinases in acquired resistance to cetuximab.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

AXL is a potential target for therapeutic intervention in breast cancer progression.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

High-throughput detection of DNA double-strand breaks using image cytometry

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

AXL inhibition sensitizes mesenchymal cancer cells to antimitotic drugs

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5032632

10.1158/1078-0432.CCR-14-2648

3 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767293%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767293%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference