Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage. (Q37288448)

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scientific article published on 27 May 2009

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English	Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.	scientific article published on 27 May 2009

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29 January 2020

Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage (English)

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29 January 2020

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29 January 2020

Micheal J Zuscik

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29 January 2020

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Qiuqian Wu

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29 January 2020

Erik R Sampson

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29 January 2020

Kyung-O K Kim

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29 January 2020

Regis J O'Keefe

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29 January 2020

Di Chen

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29 January 2020

Randy N Rosier

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29 January 2020

Experimental Cell Research

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29 January 2020

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29 January 2020

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29 January 2020

2386-2398

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29 January 2020

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.

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Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

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Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms

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A dominant interference collagen X mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice

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BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation

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6 September 2017

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

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Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation

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6 September 2017

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

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6 September 2017

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

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6 September 2017

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

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6 September 2017

TGF-beta signaling by Smad proteins

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6 September 2017

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3 September 2018

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Transcriptional control by the TGF-beta/Smad signaling system

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Smads: transcriptional activators of TGF-beta responses

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12 December 2020

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Differential effects of transforming growth factors beta 1, beta 2, beta 3 and beta 5 on chondrogenesis in mouse limb bud mesenchymal cells

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12 December 2020

based on heuristic

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Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta

1 reference

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12 December 2020

based on heuristic

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Osteoarthritic lesions: involvement of three different collagenases

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.YEXCR.2009.05.019

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29 January 2020

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29 January 2020

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29 January 2020

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