Hypoxia signalling through mTOR and the unfolded protein response in cancer (Q37290935)

19 August 2017

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title

Hypoxia signalling through mTOR and the unfolded protein response in cancer (English)

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19 August 2017

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19 August 2017

Marianne Koritzinsky

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language of work or name

English

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publication date

10 October 2008

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19 August 2017

Nature Reviews Cancer

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19 August 2017

8

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19 August 2017

11

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19 August 2017

851-864

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https://scigraph.springernature.com/pub.10.1038/nrc2501

19 August 2017

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cites work

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

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Defining the role of mTOR in cancer

31 March 2020

1 reference

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

31 March 2020

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A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

31 March 2020

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Hypoxia-induced energy stress regulates mRNA translation and cell growth

31 March 2020

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

31 March 2020

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The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

31 March 2020

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Regulation of mTOR and cell growth in response to energy stress by REDD1.

31 March 2020

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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

31 March 2020

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PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

31 March 2020

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Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb

31 March 2020

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Upstream and downstream of mTOR

31 March 2020

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A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E

31 March 2020

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Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

31 March 2020

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A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay

31 March 2020

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

31 March 2020

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Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells

31 March 2020

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Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions

31 March 2020

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Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia.

31 March 2020

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The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency

31 March 2020

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Regulation of cap-dependent translation by eIF4E inhibitory proteins

31 March 2020

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A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.

31 March 2020

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BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer

31 March 2020

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BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1 pathway and prognosis

31 March 2020

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BNIP3 as a Progression Marker in Primary Human Breast Cancer; Opposing Functions inIn situVersus Invasive Cancer

31 March 2020

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Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

31 March 2020

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Autophagy: process and function

31 March 2020

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Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3.

31 March 2020

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

31 March 2020

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Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

31 March 2020

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Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy

31 March 2020

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Autophagy in chronically ischemic myocardium.

31 March 2020

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

31 March 2020

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Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

31 March 2020

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Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

31 March 2020

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Signal integration in the endoplasmic reticulum unfolded protein response

31 March 2020

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Protein folding in the endoplasmic reticulum and the unfolded protein response.

31 March 2020

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Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

31 March 2020

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Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

31 March 2020

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ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

31 March 2020

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Translational control is required for the unfolded protein response and in vivo glucose homeostasis

31 March 2020

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XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

31 March 2020

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Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer

31 March 2020

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The role of the unfolded protein response in tumour development: friend or foe?

31 March 2020

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Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

31 March 2020

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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

31 March 2020

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

31 March 2020

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Activating transcription factor 4 is translationally regulated by hypoxic stress

31 March 2020

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Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells

31 March 2020

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Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

31 March 2020

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The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells

31 March 2020

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Enhanced synthesis of specific proteins, RNA, and DNA caused by hypoxia and reoxygenation

31 March 2020

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The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1‐Lα

31 March 2020

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Up-regulation of protein-disulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell death

31 March 2020

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IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo.

31 March 2020

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Ero1-L alpha plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer

31 March 2020

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Protein quality control in the early secretory pathway

31 March 2020

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Induction of murine HRD1 in experimental cerebral ischemia.

31 March 2020

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Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress

31 March 2020

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ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

31 March 2020

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Autophagy is activated for cell survival after endoplasmic reticulum stress

31 March 2020

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Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response

31 March 2020

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IRE1-independent gain control of the unfolded protein response

31 March 2020

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Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

31 March 2020

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

31 March 2020

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

31 March 2020

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

31 March 2020

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

31 March 2020

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Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

31 March 2020

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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

31 March 2020

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Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

31 March 2020

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Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions

31 March 2020

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Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia

31 March 2020

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Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia

31 March 2020

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Assessing IRES activity in the HIF-1alpha and other cellular 5' UTRs

31 March 2020

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Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism

31 March 2020

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Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

31 March 2020

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The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

31 March 2020

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Targeting HIF-1 for cancer therapy

31 March 2020

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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

31 March 2020

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

31 March 2020

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The interplay between MYC and HIF in cancer.

31 March 2020

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HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

31 March 2020

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Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis.

31 March 2020

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HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

31 March 2020

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Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

31 March 2020

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Role of autophagy in cancer

31 March 2020

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Hypoxia sensing and pathways of cytosolic Ca2+ increases

31 March 2020

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Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.

31 March 2020

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Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum

31 March 2020

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

31 March 2020

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Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

31 March 2020

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

31 March 2020

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Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

31 March 2020

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The HIF pathway in cancer

31 March 2020

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Hypoxia and regulation of messenger RNA translation

31 March 2020

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A microRNA signature of hypoxia

31 March 2020

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High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma

31 March 2020

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MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3

31 March 2020

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MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia

31 March 2020

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miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer

31 March 2020

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hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer

31 March 2020

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The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum

31 March 2020

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The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy

31 March 2020

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Exploiting tumour hypoxia in cancer treatment

31 March 2020

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SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

31 March 2020

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Targeting hypoxia cell signaling for cancer therapy

31 March 2020

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Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: possible role for thrombosis

31 March 2020

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Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF.

31 March 2020

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Molecular regulation of vessel maturation

31 March 2020

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The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response

31 March 2020

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HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress.

31 March 2020

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HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo

31 March 2020

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Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy

31 March 2020

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Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo

31 March 2020

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The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression

31 March 2020

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Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors

31 March 2020

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Herceptin down-regulates HER-2/neu and vascular endothelial growth factor expression and enhances taxol-induced cytotoxicity of human Ewing's sarcoma cells in vitro and in vivo.

31 March 2020

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Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1alpha

31 March 2020

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Treatment of HER-2/neu overexpressing breast cancer xenograft models with trastuzumab (Herceptin) and gefitinib (ZD1839): drug combination effects on tumor growth, HER-2/neu and epidermal growth factor receptor expression, and viable hypoxic cell fr

31 March 2020

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Modulation of intratumoral hypoxia by the epidermal growth factor receptor inhibitor gefitinib detected using small animal PET imaging

31 March 2020

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Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts

31 March 2020

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Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006)

31 March 2020

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Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus

31 March 2020

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CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling

31 March 2020

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Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer

31 March 2020

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Farnesyltransferase inhibitor effects on prostate tumor micro-environment and radiation survival

31 March 2020

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Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors

31 March 2020

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Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain

31 March 2020

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Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells

31 March 2020

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Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis

31 March 2020

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HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells

31 March 2020

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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

31 March 2020

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Rates of oxygen consumption for proliferating and quiescent cells isolated from multicellular tumor spheroids.

31 March 2020

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRC2501

1 reference

19 August 2017

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PubMed ID

18846101