Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses (Q37351778)

19 August 2017

2 references

8 February 2021

31 July 2022

Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses (English)

1 reference

hypoxia-inducible factor 1

19 August 2017

1 reference

22 December 2019

1 reference

22 December 2020

1 reference

24 January 2021

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8 February 2021

1 reference

Joanna Obacz

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1 reference

19 August 2017

Silvia Pastorekova

series ordinal

2

1 reference

19 August 2017

Borek Vojtesek

series ordinal

3

1 reference

19 August 2017

Roman Hrstka

series ordinal

4

1 reference

19 August 2017

language of work or name

1 reference

14 August 2013

12 references

19 August 2017

3 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

22 December 2019

22 December 2020

24 January 2021

8 February 2021

31 July 2022

12 references

19 August 2017

3 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

22 December 2019

22 December 2020

24 January 2021

8 February 2021

31 July 2022

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1

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Creative Commons Attribution 2.0 Generic

19 August 2017

11 references

3 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

22 December 2019

22 December 2020

24 January 2021

8 February 2021

on focus list of Wikimedia project

31 July 2022

copyright status

copyrighted

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Chaperoning of mutant p53 protein by wild-type p53 protein causes hypoxic tumor regression

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Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia

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Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death

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Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway.

6 September 2017

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Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors.

6 September 2017

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The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53-p21 axis

6 September 2017

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Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival

6 September 2017

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HIF-1α effects on angiogenic potential in human small cell lung carcinoma

6 September 2017

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Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element.

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.

6 September 2017

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Hypoxia and energetic tumour metabolism

6 September 2017

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Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

6 September 2017

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MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

6 September 2017

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The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

6 September 2017

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HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers

6 September 2017

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Role of autophagy in suppression of inflammation and cancer

6 September 2017

1 reference

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

6 September 2017

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Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration

6 September 2017

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Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha

6 September 2017

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HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms.

6 September 2017

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Kinases as upstream regulators of the HIF system: their emerging potential as anti-cancer drug targets

6 September 2017

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

6 September 2017

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Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer.

6 September 2017

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Cytoplasmic functions of the tumour suppressor p53.

6 September 2017

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IDH1 and IDH2 mutations in gliomas

6 September 2017

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The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.

6 September 2017

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P53 mRNA controls p53 activity by managing Mdm2 functions

6 September 2017

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ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.

6 September 2017

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Cancer cell metabolism: Warburg and beyond

6 September 2017

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Regulation of autophagy by cytoplasmic p53

6 September 2017

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Clinicopathologic significance of HIF-1alpha, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer

6 September 2017

1 reference

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Transcriptional control of human p53-regulated genes

6 September 2017

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Sugar and fat - that's where it's at: metabolic changes in tumors

6 September 2017

1 reference

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Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell lines

6 September 2017

1 reference

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Hypoxia: a key regulator of angiogenesis in cancer

6 September 2017

1 reference

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The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

6 September 2017

1 reference

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p53 stabilization and transactivation by a von Hippel-Lindau protein

6 September 2017

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The coordinate regulation of the p53 and mTOR pathways in cells

6 September 2017

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Inhibition of macroautophagy triggers apoptosis

6 September 2017

1 reference

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

6 September 2017

1 reference

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DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.

6 September 2017

1 reference

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Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide.

6 September 2017

1 reference

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p53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer

6 September 2017

1 reference

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On the Origin of Cancer Cells

6 September 2017

1 reference

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

6 September 2017

1 reference

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Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

6 September 2017

1 reference

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Hypoxia links ATR and p53 through replication arrest

6 September 2017

1 reference

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

6 September 2017

1 reference

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Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

6 September 2017

1 reference

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Hypoxia-inducible expression of tumor-associated carbonic anhydrases

6 September 2017

1 reference

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p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Stress signals utilize multiple pathways to stabilize p53

6 September 2017

1 reference

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Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies

6 September 2017

1 reference

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Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

6 September 2017

1 reference

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6 September 2017

1 reference

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Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

The p53-mdm-2 autoregulatory feedback loop

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Oxidative DNA damage and senescence of human diploid fibroblast cells.

6 September 2017

1 reference

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Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease

6 September 2017

1 reference

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Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases

14 September 2017

1 reference

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Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors

14 September 2017

1 reference

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Chemoradiation interactions under reduced oxygen conditions: Cellular characteristics of an in vitro model

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Response of tumour cells to hypoxia: role of p53 and NFkB.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

AG490 promotes HIF-1α accumulation by inhibiting its hydroxylation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Hypoxia-induced autophagy: cell death or cell survival?

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Poorer outcome in stromal HIF-2 alpha- and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

The P-glycoprotein multidrug transporter

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Immunohistochemical assessment of apoptosis-associated proteins: p53, Bcl-xL, Bax and Bak in gastric cancer cells in correlation with clinical and pathomorphological factors.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Molecular markers associated with response to chemotherapy in gastro-entero-pancreatic neuroendocrine tumors

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Ex vivo expansion of human mesenchymal stem cells: a more effective cell proliferation kinetics and metabolism under hypoxia.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

New roles for pyruvate kinase M2: working out the Warburg effect

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Chaperone-dependent stabilization and degradation of p53 mutants

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Hypoxia attenuates the p53 response to cellular damage

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3844392

Particulate and free hexokinase in fetal rat liver

2 September 2018

1 reference

12 December 2020

Prognostic value of vascular endothelial growth factor expression in gastric carcinoma

1 reference

12 December 2020

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix

1 reference

12 December 2020

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

12 December 2020

Clinical applications of detecting dysfunctional p53 tumor suppressor protein

1 reference

12 December 2020

Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level

1 reference

12 December 2020

Identifiers

DOI

10.1186/1476-4598-12-93

1 reference

Dimensions Publication ID

19 August 2017

0 references

1 reference

19 August 2017

PubMed publication ID

23945296

1 reference