TGF-beta signaling in vascular biology and dysfunction (Q37359962)

19 August 2017

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title

TGF-beta signaling in vascular biology and dysfunction (English)

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19 August 2017

Marie-José Goumans

1

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19 August 2017

Zhen Liu

series ordinal

2

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19 August 2017

Peter ten Dijke

series ordinal

3

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19 August 2017

language of work or name

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1 January 2009

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19 August 2017

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19 August 2017

19

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19 August 2017

1

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19 August 2017

116-127

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https://scigraph.springernature.com/pub.10.1038/cr.2008.326

19 August 2017

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cites work

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Extracellular control of TGFbeta signalling in vascular development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Endoglin in angiogenesis and vascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Betaglycan presents ligand to the TGF beta signaling receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Endoglin modulates cellular responses to TGF-beta 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Bone morphogenetic protein-9 is a circulating vascular quiescence factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Molecular regulation of angiogenesis and lymphangiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Mechanisms of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Blood vessel formation: what is its molecular basis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Angiogenesis in life, disease and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Essential role of endothelial Smad4 in vascular remodeling and integrity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Smad5 is essential for left-right asymmetry in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

A role for smad6 in development and homeostasis of the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

VE-cadherin is a critical endothelial regulator of TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

TGFbeta1 induces vasculogenesis and inhibits angiogenic sprouting in an embryonic stem cell differentiation model: respective contribution of ALK1 and ALK5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Hypoxia induces alteration of bone morphogenetic protein receptor signaling in pulmonary artery endothelial cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Endoglin expression on human microvascular endothelial cells association with betaglycan and formation of higher order complexes with TGF-beta signalling receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Endoglin expression regulates basal and TGF-beta1-induced extracellular matrix synthesis in cultured L6E9 myoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

CD105 prevents apoptosis in hypoxic endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

CD105 is important for angiogenesis: evidence and potential applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Characterization of murine S-endoglin isoform and its effects on tumor development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

L- and S-endoglin differentially modulate TGFbeta1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Transforming growth factor-betas and vascular disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Increased neointima formation in cysteine-rich protein 2-deficient mice in response to vascular injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Endoglin is required for myogenic differentiation potential of neural crest stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

SMAD proteins control DROSHA-mediated microRNA maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Development of the aortic vessel wall as defined by vascular smooth muscle and extracellular matrix markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Endothelial-mesenchymal interactions in vitro reveal molecular mechanisms of smooth muscle/pericyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Involvement of p38 MAP kinase in TGF-beta-stimulated VEGF synthesis in aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

SMAD4 mutations found in unselected HHT patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

The molecular genetics of Marfan syndrome and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Aneurysm syndromes caused by mutations in the TGF-beta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Angiotensin II blockade and aortic-root dilation in Marfan's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Preeclampsia as a cause of preterm and late preterm (near-term) births

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Soluble endoglin contributes to the pathogenesis of preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Implications of mutations of activin receptor-like kinase 1 gene (ALK1) in addition to bone morphogenetic protein receptor II gene (BMPR2) in children with pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Medical therapy for pulmonary arterial hypertension: updated ACCP evidence-based clinical practice guidelines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

TGF-beta1 and angiotensin networking in cardiac remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Essential role of Smad3 in angiotensin II-induced vascular fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Angiotensin-converting enzyme inhibition and ventricular remodeling after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Losartan for the treatment of hypertension and left ventricular hypertrophy: the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Peptide growth factors can provoke "fetal" contractile protein gene expression in rat cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Alterations of beta-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta(1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

Expression of transforming growth factor type III receptor in vascular endothelial cells increases their responsiveness to transforming growth factor beta 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

7 January 2021

Purification and properties of a type beta transforming growth factor from bovine kidney

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

7 January 2021

Endothelial progenitor cells for postnatal vasculogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

7 January 2021

Smad7 is required for the development and function of the heart

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

7 January 2021

Reduced angiogenic responses in adult Endoglin heterozygous mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

7 January 2021

Regulation of differentiation of vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

7 January 2021

Targeted disruption of TGF-beta-Smad3 signaling leads to enhanced neointimal hyperplasia with diminished matrix deposition in response to vascular injury

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

7 January 2021

BMP-2 gene expression and effects on human vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

7 January 2021

Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

7 January 2021

VEGF regulates FGF-2 and TGF-beta1 expression in injury endothelial cells and mediates smooth muscle cells proliferation and migration

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

7 January 2021

Hereditary hemorrhagic telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.326

7 January 2021

Identifiers

DOI

10.1038/CR.2008.326

1 reference

19 August 2017

1 reference