Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells. (Q37394999)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24282297%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells (English)

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1 March 2020

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3

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1 March 2020

Hongbo Chi

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1 March 2020

author name string

Yanyan Wang

1

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1 March 2020

Gonghua Huang

2

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1 March 2020

Kai Yang

4

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1 March 2020

Richard F Lamb

5

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1 March 2020

language of work or name

English

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publication date

26 November 2013

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24282297%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

1 March 2020

published in

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1 March 2020

volume

110

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1 March 2020

issue

50

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1 March 2020

page(s)

E4894-903

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Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.

1 March 2020

cites work

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6 September 2017

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6 September 2017

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Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function.

6 September 2017

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Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

6 September 2017

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

6 September 2017

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6 September 2017

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Regulation of T-cell survival and mitochondrial homeostasis by TSC1

6 September 2017

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The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

6 September 2017

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Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

6 September 2017

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Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates

6 September 2017

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HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

6 September 2017

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Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation

6 September 2017

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

6 September 2017

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Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

6 September 2017

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Rheb1 is required for mTORC1 and myelination in postnatal brain development

6 September 2017

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Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

6 September 2017

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6 September 2017

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6 September 2017

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

6 September 2017

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6 September 2017

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6 September 2017

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Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

6 September 2017

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mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS.

6 September 2017

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6 September 2017

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Differentiation of effector CD4 T cell populations (*)

6 September 2017

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

6 September 2017

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Immunoregulatory functions of mTOR inhibition.

6 September 2017

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In vivo analysis of dendritic cell development and homeostasis

6 September 2017

1 reference

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Inflammatory signals in dendritic cell activation and the induction of adaptive immunity

6 September 2017

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mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

6 September 2017

1 reference

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

6 September 2017

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TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

6 September 2017

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

6 September 2017

1 reference

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Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

6 September 2017

1 reference

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LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

6 September 2017

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Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

6 September 2017

1 reference

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The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

6 September 2017

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

6 September 2017

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The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

6 September 2017

1 reference

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Essential role for nuclear PTEN in maintaining chromosomal integrity

6 September 2017

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Monocytes give rise to mucosal, but not splenic, conventional dendritic cells

6 September 2017

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

6 September 2017

1 reference

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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

6 September 2017

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mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.

28 September 2017

1 reference

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Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.

28 September 2017

1 reference

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Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling

26 June 2018

1 reference

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A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864282

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864282

The TSC-mTOR signaling pathway regulates the innate inflammatory response

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864282

A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24282297

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24282297

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1308905110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24282297%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24282297%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference