Neuroprotective role of mitochondrial uncoupling protein 2 in cerebral stroke (Q37400589)

20 August 2017

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title

Neuroprotective role of mitochondrial uncoupling protein 2 in cerebral stroke (English)

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20 August 2017

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Suresh L Mehta

1

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PubMed ID

19240738

20 August 2017

P Andy Li

series ordinal

2

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20 August 2017

25 February 2009

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Journal of Cerebral Blood Flow & Metabolism

20 August 2017

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20 August 2017

29

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20 August 2017

1069-1078

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20 August 2017

6

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Mitochondrial uncoupling proteins in the CNS: in support of function and survival.

20 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Increased infarct size and lack of hyperphagic response after focal cerebral ischemia in peroxisome proliferator-activated receptor beta-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Increased oxidative stress during hyperglycemic cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Protective role of uncoupling protein 2 in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Cellular pathology of hilar neurons in Ammon's horn sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Effects of rosiglitazone on global ischemia-induced hippocampal injury and expression of mitochondrial uncoupling protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Decrease of intracellular ATP content downregulated UCP2 expression in mouse hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

UCP2 protects hypothalamic cells from TNF-alpha-induced damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondrial function as a determinant of recovery or death in cell response to injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Global cerebral ischemia in the rat: online monitoring of oxygen free radical production using chemiluminescence in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondrial uncoupling proteins--what is their physiological role?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Superoxide activates mitochondrial uncoupling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

The mitochondrial uncoupling protein-2: current status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Hyperglycemia and focal brain ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Molecular cloning of rat uncoupling protein 2 cDNA and its expression in genetically obese Zucker fatty (fa/fa) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondrial membrane potential and ischemic neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondrial hyperpolarization after transient oxygen-glucose deprivation and subsequent apoptosis in cultured rat hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondrial membrane potential and intracellular ATP content after transient experimental ischemia in the cultured hippocampal neuron

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Neurotoxic glutamate treatment of cultured cerebellar granule cells induces Ca2+ -dependent collapse of mitochondrial membrane potential and ultrastructural alterations of mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Fatty acid interaction with mitochondrial uncoupling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

'Mild Uncoupling' does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Roles of PPARs in health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

The modulating effects of the overexpression of uncoupling protein 2 on the formation of reactive oxygen species in vascular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling proteins: the issues from a biochemist point of view

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Calcium in ischemic cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Sites of generation of reactive oxygen species in homogenates of brain tissue determined with the use of respiratory substrates and inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Hyperglycemia-exaggerated ischemic brain damage following 30 min of middle cerebral artery occlusion is not due to capillary obstruction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Role of hyperglycaemia-related acidosis in ischaemic brain damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondrial uncoupling as a potential therapeutic target in acute central nervous system injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Oxidative and nitrosative stress in brain mitochondria of diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

The emerging functions of UCP2 in health, disease, and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Delayed ischemic preconditioning activates nuclear-encoded electron-transfer-chain gene expression in parallel with enhanced postanoxic mitochondrial respiratory recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Molecular targets in cerebral ischemia for developing novel therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Streptozotocin-induced diabetes causes astrocyte death after ischemia and reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

The effects of the overexpression of recombinant uncoupling protein 2 on proliferation, migration and plasminogen activator inhibitor 1 expression in human vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Coregulator codes of transcriptional regulation by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Cardiac UCP2 expression and myocardial oxidative metabolism during acute septic shock in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

High glucose-induced oxidative stress and mitochondrial dysfunction in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

T(3) increases mitochondrial ATP production in oxidative muscle despite increased expression of UCP2 and -3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling: new approaches to an old problem of bioenergetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Hypoxic remodeling of Ca2+ stores in type I cortical astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

21 January 2018

Glucose neurotoxicity

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https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling is without an effect on the production of reactive oxygen species by in situ synaptic mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

21 January 2018

The PPAR resource page.

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

Penumbral tissue alkalosis in focal cerebral ischemia: relationship to energy metabolism, blood flow, and steady potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells.

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Metabolism of glucose into glutamate via the hexose monophosphate shunt and its inhibition by 6-aminonicotinamide in rat brain in vivo

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Overexpression of UCP3 in cultured human muscle lowers mitochondrial membrane potential, raises ATP/ADP ratio, and favors fatty acid vs. glucose oxidation.

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Tissue-specific expression of the uncoupling protein family in streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers.

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

The influence of plasma glucose concentrations on ischemic brain damage is a threshold function

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

UCP2 muscle gene transfer modifies mitochondrial membrane potential

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency.

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Amplified expression of uncoupling proteins in human brain ischemic lesions

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Transient focal ischemia in hyperglycemic rats is associated with increased cerebral infarction

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Depolarization-induced mitochondrial Ca accumulation in sympathetic neurons: spatial and temporal characteristics

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Uncoupling protein 2 in the brain: distribution and function

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Glucose potassium insulin infusions in the treatment of acute stroke patients with mild to moderate hyperglycemia: the Glucose Insulin in Stroke Trial (GIST)

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Inositol trisphosphate, polyphosphoinositide turnover, and high-energy metabolites in focal cerebral ischemia and reperfusion

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2009.4

7 January 2021

Identifiers

DOI

10.1038/JCBFM.2009.4

1 reference

20 August 2017

1 reference

PubMed ID

19240738