Functional characterization of the cAMP-binding proteins Epac in cardiac myocytes (Q37421184)

20 August 2017

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title

Functional characterization of the cAMP-binding proteins Epac in cardiac myocytes (English)

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20 August 2017

7

Frank Lezoualc'h

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Mélanie Métrich

1

Mélanie Métrich

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Magali Berthouze

3

Magali Berthouze

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Eric Morel

Eric Morel

2

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Laetitia Pereira

Laetitia Pereira

4

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Philippe Charron

Philippe Charron

5

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author name string

Ana-Maria Gomez

6

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20 August 2017

publication date

1 January 2009

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20 August 2017

published in

Pharmacological Reports

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20 August 2017

volume

61

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20 August 2017

issue

1

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20 August 2017

page(s)

146-153

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Cyclic nucleotide research -- still expanding after half a century

20 August 2017

cites work

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Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting

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Epac proteins: multi-purpose cAMP targets

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7 January 2021

Epac and PKA: a tale of two intracellular cAMP receptors

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7 January 2021

Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase

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7 January 2021

Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition

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7 January 2021

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

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7 January 2021

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

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7 January 2021

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

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7 January 2021

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

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7 January 2021

Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B

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7 January 2021

Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases.

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7 January 2021

Hypertrophy of the heart: a new therapeutic target?

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Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies

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Ras proteins: different signals from different locations

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7 January 2021

The epidemiology of heart failure: the Framingham Study

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Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell

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7 January 2021

Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

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7 January 2021

Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart

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7 January 2021

Signaling pathways for cardiac hypertrophy and failure

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7 January 2021

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

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7 January 2021

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

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7 January 2021

A family of cAMP-binding proteins that directly activate Rap1

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7 January 2021

Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors

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7 January 2021

Calcium and cardiomyopathies.

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PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways

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7 January 2021

Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study

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7 January 2021

The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane

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7 January 2021

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

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7 January 2021

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

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7 January 2021

AKAP signaling complexes: getting to the heart of the matter

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7 January 2021

Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy

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7 January 2021

cAMP-binding protein Epac induces cardiomyocyte hypertrophy.

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7 January 2021

Alterations in cAMP-mediated signaling and their role in the pathophysiology of dilated cardiomyopathy

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7 January 2021

Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes

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7 January 2021

The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes

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7 January 2021

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

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7 January 2021

Cyclic nucleotide analogs as probes of signaling pathways.

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7 January 2021

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

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7 January 2021

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

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7 January 2021

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

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7 January 2021

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

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7 January 2021

Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

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7 January 2021

Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac

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7 January 2021

Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.

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7 January 2021

Epac: effectors and biological functions

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7 January 2021

Integration of calcium with the signaling network in cardiac myocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970017-9

7 January 2021

A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970017-9

7 January 2021

Epac and the cardiovascular system

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970017-9

7 January 2021

Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970017-9

7 January 2021

Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970017-9

7 January 2021

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970017-9

7 January 2021

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970017-9

7 January 2021

The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2809%2970017-9

7 January 2021

10.1016/S1734-1140(09)70017-9

Identifiers

DOI

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20 August 2017

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