Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus (Q37429069)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19880748%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus (English)

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11 February 2020

2

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11 February 2020

Malin Flodström-Tullberg

4

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11 February 2020

Cecile King

6

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11 February 2020

5

Jonathan Sprent

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11 February 2020

author name string

Helen M McGuire

1

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11 February 2020

Natasha Hill

3

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11 February 2020

language of work or name

English

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publication date

30 October 2009

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11 February 2020

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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11 February 2020

volume

106

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issue

46

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11 February 2020

page(s)

19438-19443

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Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.

11 February 2020

cites work

1 reference

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Interleukin-21 is required for the development of type 1 diabetes in NOD mice

23 August 2017

1 reference

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The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

IL-21 signaling is critical for the development of type I diabetes in the NOD mouse

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

23 August 2017

1 reference

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Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes

23 August 2017

1 reference

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Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

23 August 2017

1 reference

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IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes

23 August 2017

1 reference

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

CD25+ regulatory T cell depletion augments immunotherapy of micrometastases by an IL-21-secreting cellular vaccine

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Calcium-dependent activation of interleukin-21 gene expression in T cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Transgenic mice expressing constitutive levels of IL-2 in islet beta cells develop diabetes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases

28 September 2017

1 reference

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Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4+ CD25+ Foxp3+ regulatory T cells.

2 September 2018

1 reference

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Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

2 September 2018

1 reference

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Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2780811

DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

2 September 2018

1 reference

12 December 2020

Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses

1 reference

12 December 2020

Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies

1 reference

12 December 2020

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex

1 reference

12 December 2020

Interleukin 2 receptor targeted fusion toxin (DAB486-IL-2) treatment blocks diabetogenic autoimmunity in non-obese diabetic mice

1 reference

12 December 2020

Genetic requirements for acceleration of diabetes in non-obese diabetic mice expressing interleukin-2 in islet beta-cells

1 reference

12 December 2020

Alternative pathways for the selection of antigen-specific peripheral T cells

1 reference

12 December 2020

A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0903561106

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11 February 2020

0 references

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11 February 2020

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