Targeting histone deacetylases for heart failure (Q37494673)

20 August 2017

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title

Targeting histone deacetylases for heart failure (English)

1 reference

20 August 2017

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Erik W Bush

1

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PubMed ID

19466913

20 August 2017

Timothy A McKinsey

series ordinal

2

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PubMed ID

19466913

20 August 2017

language of work or name

English

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publication date

1 July 2009

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Expert Opinion on Therapeutic Targets

20 August 2017

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20 August 2017

13

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20 August 2017

767-784

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20 August 2017

7

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Acetylation and deacetylation of non-histone proteins

20 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Class II histone deacetylases: versatile regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

HDAC6 is a microtubule-associated deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Sirtuins in aging and age-related disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Prognostic significance of left ventricular mass change during treatment of hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Hypertrophy of the heart: a new therapeutic target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

MEF2: a calcium-dependent regulator of cell division, differentiation and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Calcium/calmodulin-dependent protein kinase activates serum response factor transcription activity by its dissociation from histone deacetylase, HDAC4. Implications in cardiac muscle gene regulation during hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Myocardin induces cardiomyocyte hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Roles of cardiac transcription factors in cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

14-3-3 regulates the nuclear import of class IIa histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Protein kinase D signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Regulation of cardiac stress signaling by protein kinase d1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Requirement of protein kinase D1 for pathological cardiac remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

An expression screen reveals modulators of class II histone deacetylase phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Derepression of pathological cardiac genes by members of the CaM kinase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Cardiomyocyte calcium and calcium/calmodulin-dependent protein kinase II: friends or foes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

PP2A regulates HDAC4 nuclear import

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Shuttling of HDAC5 in H9C2 cells regulates YY1 function through CaMKIV/PKD and PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Caspase-mediated specific cleavage of human histone deacetylase 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Dephosphorylation and caspase processing generate distinct nuclear pools of histone deacetylase 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Requirement of protein kinase D tyrosine phosphorylation for VEGF-A165-induced angiogenesis through its interaction and regulation of phospholipase Cgamma phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Interleukin-2 transcriptional block by multifunctional Ca2+/calmodulin kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Control of muscle development by dueling HATs and HDACs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

SUMOylation substrates in neuronal intranuclear inclusion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

HDAC4 regulates neuronal survival in normal and diseased retinas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

HDAC4 inhibits cell-cycle progression and protects neurons from cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Neuroprotection by histone deacetylase-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Bone morphogenetic protein-2 stimulates Runx2 acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

MEF-2 function is modified by a novel co-repressor, MITR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Kinetics and comparative reactivity of human class I and class IIb histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Activation of histone deacetylase 2 by inducible heat shock protein 70 in cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Myocyte apoptosis in heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Epigenetic regulation of airway inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Myosin heavy chain isoform expression in the failing and nonfailing human heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Myosin heavy chain gene expression in human heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Small amounts of alpha-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Power output is linearly related to MyHC content in rat skinned myocytes and isolated working hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Forced expression of alpha-myosin heavy chain in the rabbit ventricle results in cardioprotection under cardiomyopathic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Control of cardiac myosin heavy chain gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Effect of serum triiodothyronine on regulation of cardiac gene expression: role of histone acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Anticancer activities of histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

A review of depsipeptide and other histone deacetylase inhibitors in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Transcription therapy for acute promyelocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Transcription therapy for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

New therapeutic targets in cancer: the epigenetic connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Regulatory cross-talk between lysine acetylation and ubiquitination: role in the control of protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase inhibition and estrogen signalling in human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Potentiation of androgen receptor transcriptional activity by inhibition of histone deacetylation--rescue of transcriptionally compromised mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone deacetylase inhibitors: a novel therapeutic approach to Huntington's disease (complex mechanism of neuronal death).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Challenges and opportunities in clinical trials for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Microtubule stabilization in pressure overload cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

The role of the cytoskeleton in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

The ubiquitin-proteasome system: focus on the heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Into the heart: the emerging role of the ubiquitin-proteasome system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Using Yeast to Discover the Fountain of Youth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

DNA repair, genome stability, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Sirt1 regulates aging and resistance to oxidative stress in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Inhibitory effect of resveratrol on angiotensin II-induced cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Effects of intravenous ABT-870 (iron (III)-hydroxide oligosaccharide) on mean arterial pressure and heart rate in the anaesthetized beagle: comparison with other iron-containing haematinic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Resveratrol: one molecule, many targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Myocyte Enhancer Factors 2A and 2C Induce Dilated Cardiomyopathy in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

Protein kinase D directly phosphorylates histone deacetylase 5 via a random sequential kinetic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902939161

10.1517/14728220902939161

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19466913