Nuclear receptors: the controlling force in drug metabolism of the liver? (Q37557625)

21 August 2017

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title

Nuclear receptors: the controlling force in drug metabolism of the liver? (English)

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21 August 2017

N Plant

1

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author name string

S Aouabdi

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

1 August 2009

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21 August 2017

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21 August 2017

volume

39

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21 August 2017

issue

8

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21 August 2017

page(s)

597-605

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Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors

21 August 2017

cites work

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21 January 2018

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A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

21 January 2018

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FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

21 January 2018

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Transcriptional corepression by SHP: molecular mechanisms and physiological consequences

21 January 2018

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Localization and differential induction of cytochrome P450IVA and acyl-CoA oxidase in rat liver

21 January 2018

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

21 January 2018

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Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene

21 January 2018

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Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

21 January 2018

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Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.

21 January 2018

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Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

21 January 2018

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Gene expression profiling of the PPAR-alpha agonist ciprofibrate in the cynomolgus monkey liver

21 January 2018

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Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1α)-deficient mice

21 January 2018

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Species differences in peroxisome proliferation; mechanisms and relevance.

21 January 2018

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Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth

21 January 2018

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Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha

21 January 2018

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Regulation of a transcription factor network required for differentiation and metabolism

21 January 2018

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The PXR crystal structure: the end of the beginning

21 January 2018

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Coordinate transcriptional regulation of transport and metabolism

21 January 2018

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Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element

21 January 2018

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Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling

21 January 2018

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Nuclear receptors and the control of metabolism

21 January 2018

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On the mechanism of DNA binding by nuclear hormone receptors: a structural and functional perspective

21 January 2018

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Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor

21 January 2018

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Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

21 January 2018

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Transcriptional regulation of the human pregnane-X receptor

21 January 2018

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Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer

21 January 2018

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Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression

21 January 2018

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Thioesterase activity and acyl-CoA/fatty acid cross-talk of hepatocyte nuclear factor-4{alpha}

21 January 2018

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

21 January 2018

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Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

21 January 2018

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Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

21 January 2018

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DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region

21 January 2018

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Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor

21 January 2018

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Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development

21 January 2018

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

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Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

21 January 2018

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Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

21 January 2018

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

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Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors

21 January 2018

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Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

21 January 2018

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The SRC family of nuclear receptor coactivators

21 January 2018

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The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily

21 January 2018

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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

21 January 2018

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Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

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Identification of a nuclear receptor for bile acids

21 January 2018

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The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse

21 January 2018

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Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator

21 January 2018

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Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

21 January 2018

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

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Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3.

21 January 2018

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Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element

21 January 2018

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The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

21 January 2018

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Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?

21 January 2018

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Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth

21 January 2018

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The human cytochrome P450 sub-family: transcriptional regulation, inter-individual variation and interaction networks

21 January 2018

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The peroxisome proliferators are hepatocyte mitogens in chemically-defined media: glucocorticoid-induced PPAR alpha is linked to peroxisome proliferator mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098218

The coordinate regulation of DNA synthesis and suppression of apoptosis is differentially regulated by the liver growth agents, phenobarbital and methylclofenapate

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098218

Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098218

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098218

Identification of novel estrogen receptor alpha antagonists

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098218

Regulation of nuclear retention of glucocorticoid receptor by nuclear Hsp90.

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

21 January 2018

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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

21 January 2018

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Major events in the genome evolution of vertebrates: paranome age and size differ considerably between ray-finned fishes and land vertebrates

21 January 2018

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Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098218

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

Interaction networks: coordinating responses to xenobiotic exposure

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250903098218

HNF4: A central regulator of hepatocyte differentiation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098218

10.1080/00498250903098218

21 January 2018

Identifiers

DOI

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21 August 2017

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