Therapeutic interventions ameliorating prion disease (Q37557690)

21 August 2017

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title

Therapeutic interventions ameliorating prion disease (English)

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21 August 2017

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4

Colin L Masters

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21 August 2017

Marcus W Brazier

1

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21 August 2017

Vanessa A Wall

series ordinal

2

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21 August 2017

Barry W Brazier

series ordinal

3

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21 August 2017

Steven J Collins

series ordinal

5

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21 August 2017

publication date

1 February 2009

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Expert Review of Anti-infective Therapy

21 August 2017

published in

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21 August 2017

volume

7

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21 August 2017

issue

1

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21 August 2017

page(s)

83-105

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Prion agent diversity and species barrier.

21 August 2017

cites work

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https://api.crossref.org/works/10.1586%2F14787210.7.1.83

21 January 2018

Prion Protein Biology

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Iatrogenic Creutzfeldt-Jakob disease: the waning of an era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: background, evolution, and current concerns

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Increased susceptibility to Kuru of carriers of the PRNP 129 methionine/methionine genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Kuru in the 21st century--an acquired human prion disease with very long incubation periods

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Pathologic conformations of prion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

PrP(C) association with lipid rafts in the early secretory pathway stabilizes its cellular conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

The prion protein requires cholesterol for cell surface localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Physiology of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Identification of a protein that purifies with the scrapie prion

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

In vitro generation of infectious scrapie prions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Synthetic mammalian prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Formation of native prions from minimal components in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Protein-only transmission of three yeast prion strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Mice devoid of PrP are resistant to scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Prions: protein only or something more? Overview of potential prion cofactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Structural changes of the prion protein in lipid membranes leading to aggregation and fibrillization

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

RNA molecules stimulate prion protein conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Deadly conformations--protein misfolding in prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

The most infectious prion protein particles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

N-terminal domain of yeast Hsp104 chaperone is dispensable for thermotolerance and prion propagation but necessary for curing prions by Hsp104 overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Porphyrin and phthalocyanine antiscrapie compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Prions and transmissible spongiform encephalopathy (TSE) chemotherapeutics: A common mechanism for anti-TSE compounds?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Potent inhibition of scrapie-associated PrP accumulation by congo red

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

The anti-prion activity of Congo red. Putative mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Delineating common molecular mechanisms in Alzheimer's and prion diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Dominant-negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Dominant-negative inhibition of prion replication in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Intracerebroventricular delivery of dominant negative prion protein in a mouse model of iatrogenic Creutzfeldt-Jakob disease after dura graft transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Histopathological similarities between scrapie and cuprizone toxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Location and properties of metal-binding sites on the human prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

The cellular prion protein binds copper in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Aberrant metal binding by prion protein in human prion disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Copper stimulates endocytosis of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Normal prion protein has an activity like that of superoxide dismutase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Consequences of manganese replacement of copper for prion protein function and proteinase resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Copper binding to the prion protein: structural implications of four identical cooperative binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Copper chelation delays the onset of prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Copper binding to PrPC may inhibit prion disease propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Prion clearance in bigenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Suppression of prion protein in livestock by RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Chaperoning prions: the cellular machinery for propagating an infectious protein?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Immunotherapy as a therapeutic treatment for neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Immunization delays the onset of prion disease in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Mucosal vaccination delays or prevents prion infection via an oral route.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Intranasal immunization of Balb/c mice against prion protein attenuates orally acquired transmissible spongiform encephalopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

DNA vaccination can break immunological tolerance to PrP in wild-type mice and attenuates prion disease after intracerebral challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Postexposure prophylaxis against prion disease with a stimulator of innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Complete Freund's adjuvant immunization prolongs survival in experimental prion disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Immunoaffinity purification and neutralization of scrapie prion infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

KDEL-tagged anti-prion intrabodies impair PrP lysosomal degradation and inhibit scrapie infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

CNS delivery of vectored prion-specific single-chain antibodies delays disease onset

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Impaired prion replication in spleens of mice lacking functional follicular dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Effect of intraventricular infusion of anti-prion protein monoclonal antibodies on disease progression in prion-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Toxic effects of intracerebral PrP antibody administration during the course of BSE infection in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Effective gene therapy in a mouse model of prion diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

A systematic review of prion therapeutics in experimental models

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Evaluation of drugs for treatment of prion infections of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Locally disordered conformer of the hamster prion protein: a crucial intermediate to PrPSc?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Hot spots in prion protein for pathogenic conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Simvastatin prolongs survival times in prion infections of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Dimethyl sulfoxide delays PrP sc accumulation and disease symptoms in prion-infected hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Prolongation of scrapie incubation period by an injection of dextran sulphate 500 within the month before or after infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Chemoprophylaxis of scrapie in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Enhanced antiscrapie effect using combination drug treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Genetic prion disease: the EUROCJD experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Compassionate use of quinacrine in Creutzfeldt-Jakob disease fails to show significant effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Quinacrine does not prolong survival in a murine Creutzfeldt-Jakob disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Correlative studies support lipid peroxidation is linked to PrPres propagation as an early primary pathogenic event in prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Strain-specific prion-protein conformation determined by metal ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Treatment by CpG or Flt3-ligand does not affect mouse susceptibility to BSE prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

Monoclonal antibodies inhibit prion replication and delay the development of prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.7.1.83

21 January 2018

Identifiers

DOI

10.1586/14787210.7.1.83

1 reference

21 August 2017

1 reference