Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits (Q37615991)

21 August 2017

Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits (English)

1 reference

21 August 2017

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0 references

0 references

Jogender Mehla

1

1 reference

21 August 2017

Balwantsinh C Chauhan

series ordinal

2

1 reference

21 August 2017

Neelima B Chauhan

series ordinal

3

1 reference

21 August 2017

1 January 2014

1 reference

Journal of Alzheimer's Disease

21 August 2017

1 reference

21 August 2017

39

1 reference

21 August 2017

1

1 reference

21 August 2017

145-162

1 reference

describes a project that uses

21 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3941701/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Protein oxidation in metabolic syndrome

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The impairment of insulin signaling in Alzheimer's disease

23 August 2017

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Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

23 August 2017

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Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells

23 August 2017

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The inflammation highway: metabolism accelerates inflammatory traffic in obesity

23 August 2017

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Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition

23 August 2017

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Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcZNO10/LTJ mice

23 August 2017

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NF-κB in Aging and Disease

23 August 2017

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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity

23 August 2017

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Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease

23 August 2017

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IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation

23 August 2017

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Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

23 August 2017

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Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model

23 August 2017

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23 August 2017

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Linking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators

23 August 2017

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The role of insulin receptor signaling in synaptic plasticity and cognitive function

23 August 2017

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Why pleiotropic interventions are needed for Alzheimer's disease.

23 August 2017

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GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.

23 August 2017

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Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes

23 August 2017

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Insulin receptor signaling in the development of neuronal structure and function.

23 August 2017

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The relationship between Alzheimer's disease and diabetes: Type 3 diabetes?

23 August 2017

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Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis.

23 August 2017

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The role of IGF-1 receptor and insulin receptor signaling for the pathogenesis of Alzheimer's disease: from model organisms to human disease

23 August 2017

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23 August 2017

Insulin and the brain

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Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

23 August 2017

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Regulated proteolysis of RAGE and AbetaPP as possible link between type 2 diabetes mellitus and Alzheimer's disease

23 August 2017

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Common pathological processes and transcriptional pathways in Alzheimer's disease and type 2 diabetes

23 August 2017

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Classification and basic pathology of Alzheimer disease

23 August 2017

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Epidemilogical trends strongly suggest exposures as etiologic agents in the pathogenesis of sporadic Alzheimer's disease, diabetes mellitus, and non-alcoholic steatohepatitis.

23 August 2017

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Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study

23 August 2017

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The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged

23 August 2017

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Senescence-accelerated mouse (SAM) with special references to neurodegeneration models, SAMP8 and SAMP10 mice

23 August 2017

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(Pre)diabetes, brain aging, and cognition

23 August 2017

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The relationship between dysglycemia and cognitive dysfunction.

23 August 2017

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Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis

23 August 2017

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From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8).

23 August 2017

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23 August 2017

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Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

23 August 2017

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Mouse models of Alzheimer's dementia: current concepts and new trends

23 August 2017

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Diabetes mellitus and cognition: is there a link?

23 August 2017

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Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats.

23 August 2017

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Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair

23 August 2017

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Criteria for creating and assessing mouse models of diabetic neuropathy

23 August 2017

1 reference

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Role of insulin metabolism disturbances in the development of Alzheimer disease: mini review.

23 August 2017

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Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach

23 August 2017

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Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency

23 August 2017

1 reference

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Small animal models of cardiovascular disease: tools for the study of the roles of metabolic syndrome, dyslipidemia, and atherosclerosis

23 August 2017

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The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease

23 August 2017

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Insulin signaling in the central nervous system: learning to survive

23 August 2017

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The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's disease

23 August 2017

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Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

23 August 2017

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Pathological aging of the brain: an overview

23 August 2017

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The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease

23 August 2017

1 reference

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

23 August 2017

1 reference

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Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.

23 August 2017

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The glamour and gloom of glycogen synthase kinase-3

23 August 2017

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The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease

23 August 2017

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Insulin and the insulin receptor in experimental models of learning and memory.

23 August 2017

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Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

23 August 2017

1 reference

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Potential roles of insulin and IGF-1 in Alzheimer's disease.

23 August 2017

1 reference

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GSK-3: tricks of the trade for a multi-tasking kinase

23 August 2017

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Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly

23 August 2017

1 reference

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Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele

23 August 2017

1 reference

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Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta

23 August 2017

1 reference

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The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review

23 August 2017

1 reference

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Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta

23 August 2017

1 reference

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Neuroinflammation and neurodegeneration in overnutrition-induced diseases

23 August 2017

1 reference

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The immunopathogenic role of reactive oxygen species in Alzheimer disease.

6 September 2017

1 reference

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Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection

6 September 2017

1 reference

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Insulin and Alzheimer's disease: untangling the web.

6 September 2017

1 reference

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Inflammation in aging: cause, effect, or both?

6 September 2017

1 reference

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Insulin resistance in the brain: an old-age or new-age problem?

6 September 2017

1 reference

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Insulin resistance and pathological brain ageing

6 September 2017

1 reference

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Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis

6 September 2017

1 reference

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The role of GLP-1 in neuronal activity and neurodegeneration

6 September 2017

1 reference

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Alzheimer's Disease: A General Introduction and Pathomechanism

6 September 2017

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Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus.

6 September 2017

1 reference

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Insulin promotes survival of amyloid-beta oligomers neuroblastoma damaged cells via caspase 9 inhibition and Hsp70 upregulation.

6 September 2017

1 reference

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Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site

14 September 2017

1 reference

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Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice

28 September 2017

1 reference

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Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice.

28 September 2017

1 reference

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Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin

25 June 2018

1 reference

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Antisense inhibition at the beta-secretase-site of beta-amyloid precursor protein reduces cerebral amyloid and acetyl cholinesterase activity in Tg2576.

25 June 2018

1 reference

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Increased Aβ production prompts the onset of glucose intolerance and insulin resistance.

25 June 2018

1 reference

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Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Restoration of cognitive deficits after statin feeding in TBI.

1 September 2018

1 reference

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Central insulin resistance and synaptic dysfunction in intracerebroventricular-streptozotocin injected rodents.

1 September 2018

1 reference

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The n-terminal 5-MER peptide analogue P165 of amyloid precursor protein exerts protective effects on SH-SY5Y cells and rat hippocampus neuronal synapses.

1 September 2018

1 reference

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Synergistic benefits of erythropoietin and simvastatin after traumatic brain injury.

1 September 2018

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Neuroanatomical correlation of behavioral deficits in the CCI model of TBI.

1 September 2018

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A novel model of type 2 diabetes mellitus based on obesity induced by high-fat diet in BDF1 mice

1 September 2018

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Amyloid precursor protein expression is upregulated in adipocytes in obesity.

1 September 2018

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Impaired insulin secretion increases the risk of Alzheimer disease

1 September 2018

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The pathological interaction between diabetes and presymptomatic Alzheimer's disease

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Amelioration of early cognitive deficits by aged garlic extract in Alzheimer's transgenic mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Intracerebroventricular passive immunization with anti-oligoAbeta antibody in TgCRND8.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Insulin resistance and type 2 diabetes in high-fat-fed mice are linked to high glycotoxin intake

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Effects of lovastatin and pravastatin on amyloid processing and inflammatory response in TgCRND8 brain

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Involvement of glycogen synthase kinase-3beta and tau phosphorylation in neuronal Golgi disassembly

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Brain Abeta amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Abeta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941701

Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24121970

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3233/JAD-131238

1 reference

21 August 2017

1 reference

21 August 2017

PubMed publication ID

24121970

1 reference