The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation (Q37627659)

21 August 2017

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title

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation (English)

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21 August 2017

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Thomas Mandrup-Poulsen

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T Mandrup-Poulsen

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2

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author name string

H Kolb

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1

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21 August 2017

5 November 2009

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21 August 2017

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21 August 2017

53

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21 August 2017

10-20

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21 August 2017

1

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https://scigraph.springernature.com/pub.10.1007/s00125-009-1573-7

21 August 2017

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Obesity is associated with macrophage accumulation in adipose tissue

21 January 2018

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Metabolic obesity: the paradox between visceral and subcutaneous fat.

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Cholera toxin B pretreatment of macrophages and monocytes diminishes their proinflammatory responsiveness to lipopolysaccharide

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Exercise as a mean to control low-grade systemic inflammation

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N-acetylcysteine supplementation and oxidative damage and inflammatory response after eccentric exercise

21 January 2018

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Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

21 January 2018

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Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

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Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression

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12 December 2020

Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk.

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12 December 2020

High glucose induces toll-like receptor expression in human monocytes: mechanism of activation

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The metabolic syndrome sensitizes leukocytes for glucose-induced immune gene expression.

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The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study.

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Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals.

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Persistent hypoglycemia in a patient with diabetes taking etanercept for the treatment of psoriasis

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Evidence for a cytokine model of cognitive function

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Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors

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Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression

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Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells.

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Adipocyte death, adipose tissue remodeling, and obesity complications

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Cytokines derived from cultured skeletal muscle cells after mechanical strain promote neutrophil chemotaxis in vitro.

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12 December 2020

IKK-beta links inflammation to obesity-induced insulin resistance

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12 December 2020

Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes

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Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes

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12 December 2020

Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart

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12 December 2020

Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects

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Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects

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Palmitic acid induces IP-10 expression in human macrophages via NF-kappaB activation

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Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

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Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women.

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12 December 2020

TLR4 links innate immunity and fatty acid-induced insulin resistance

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12 December 2020

High glucose induces IL-1beta expression in human monocytes: mechanistic insights

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12 December 2020

A meal rich in oleic acid beneficially modulates postprandial sICAM-1 and sVCAM-1 in normotensive and hypertensive hypertriglyceridemic subjects

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12 December 2020

Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects.

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12 December 2020

Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance

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12 December 2020

An immune origin of type 2 diabetes?

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12 December 2020

Insulin sensitivity: modulation by nutrients and inflammation

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12 December 2020

Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins.

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12 December 2020

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12 December 2020

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

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12 December 2020

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

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12 December 2020

Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-α, and C-reactive protein to a high-fat dietary load

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12 December 2020

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

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12 December 2020

Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus.

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12 December 2020

Diet-induced inflammation of the hypothalamus in obesity.

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12 December 2020

Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis

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12 December 2020

High-glycemic index carbohydrate increases nuclear factor-kappaB activation in mononuclear cells of young, lean healthy subjects

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12 December 2020

Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study

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12 December 2020

Effects of tumor necrosis factor-alpha blockade on metabolic syndrome components in psoriasis and psoriatic arthritis and additional lessons learned from rheumatoid arthritis

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12 December 2020

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12 December 2020

The adipose triglyceride lipase, adiponectin and visfatin are downregulated by tumor necrosis factor-alpha (TNF-alpha) in vivo

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12 December 2020

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

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12 December 2020

Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells

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12 December 2020

Diabetes and the vitamin d connection

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12 December 2020

Salicylates increase insulin secretion in healthy obese subjects

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12 December 2020

Nutrient sensing and inflammation in metabolic diseases

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12 December 2020

Reduced sleep duration or quality: relationships with insulin resistance and type 2 diabetes

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12 December 2020

Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity

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12 December 2020

Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

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12 December 2020

Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese.

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12 December 2020

Hyperglycemia increases the levels of vascular cellular adhesion molecule-1 and monocyte-chemoattractant-protein-1 in the diabetic endothelial cell

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12 December 2020

Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States

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12 December 2020

Interaction of beta-cell activity and IL-1 concentration and exposure time in isolated rat islets of Langerhans.

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12 December 2020

Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}.

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12 December 2020

Salsalate improves glycemia and inflammatory parameters in obese young adults

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12 December 2020

Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase

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12 December 2020

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

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12 December 2020

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia.

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12 December 2020

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

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12 December 2020

Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress

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12 December 2020

Changes in circulating postprandial proinflammatory cytokine concentrations in diet-controlled type 2 diabetes and the effect of ingested fat

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12 December 2020

Sleep loss activates cellular inflammatory signaling

1 reference

12 December 2020

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance

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12 December 2020

Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway

1 reference

12 December 2020

Diabetes mellitus, glycemic control, and incident depressive symptoms among 70- to 79-year-old persons: the health, aging, and body composition study.

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12 December 2020

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality.

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12 December 2020

Fatty acids potentiate interleukin-1beta toxicity in the beta-cell line INS-1E.

1 reference

12 December 2020

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

1 reference

12 December 2020

Modulation of C-reactive protein, tumor necrosis factor-alpha, and adiponectin by diet, exercise, and weight loss

1 reference

12 December 2020

Inflammation and race and gender differences in computerized tomography-measured adipose depots

1 reference

12 December 2020

Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect.

1 reference

12 December 2020

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

1 reference

12 December 2020

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

1 reference

12 December 2020

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets

1 reference

12 December 2020

Exaggerated expression of skeletal muscle-derived interleukin-6, but not TNFalpha, in mice lacking interleukin-10.

1 reference

12 December 2020

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

1 reference

12 December 2020

The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease

1 reference

12 December 2020

10.1007/S00125-009-1573-7

Identifiers

DOI

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21 August 2017

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PubMed ID

19890624