The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics (Q37631442)

21 August 2017

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title

The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics (English)

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21 August 2017

Tracy A Brooks

1

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21 August 2017

Laurence H Hurley

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

12 November 2009

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21 August 2017

published in

Nature Reviews Cancer

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21 August 2017

volume

9

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21 August 2017

issue

12

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21 August 2017

page(s)

849-861

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Formation of (dA-dT)n cruciforms in Escherichia coli cells under different environmental conditions

21 August 2017

cites work

1 reference

Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo

21 January 2018

1 reference

Heterogeneous nuclear ribonucleoprotein K is a transcription factor

21 January 2018

1 reference

Over-expression of the c-myc proto-oncogene in colorectal carcinoma

21 January 2018

1 reference

Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia.

21 January 2018

1 reference

DNA and its associated processes as targets for cancer therapy

21 January 2018

1 reference

Targeting cancer with small molecule kinase inhibitors

31 March 2020

1 reference

Reflecting on 25 years with MYC.

31 March 2020

1 reference

Transcriptional regulation and transformation by Myc proteins

31 March 2020

1 reference

Extreme instability of myc mRNA in normal and transformed human cells.

31 March 2020

1 reference

c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells

31 March 2020

1 reference

Transcription control and differentiation: the HLH family, c-myc and C/EBP.

31 March 2020

1 reference

The protein encoded by the human proto-oncogene c-myc

31 March 2020

1 reference

Genomic targets of the human c-Myc protein

31 March 2020

1 reference

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

31 March 2020

1 reference

Global mapping of c-Myc binding sites and target gene networks in human B cells

31 March 2020

1 reference

Analysis of genomic targets reveals complex functions of MYC.

31 March 2020

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Transcription-independent functions of MYC: regulation of translation and DNA replication

31 March 2020

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c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry

31 March 2020

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c-Myc induces changes in higher order rDNA structure on stimulation of quiescent cells

31 March 2020

1 reference

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

31 March 2020

1 reference

Apoptotic signaling by c-MYC.

31 March 2020

1 reference

The c-myc promoter: still MysterY and challenge

31 March 2020

1 reference

31 March 2020

1 reference

The Myc oncoprotein as a therapeutic target for human cancer

31 March 2020

1 reference

The role of c-myc in the proliferation of normal and neoplastic cells

31 March 2020

1 reference

MYC is a metastasis gene for non-small-cell lung cancer

31 March 2020

1 reference

Estrogen regulation of vascular endothelial growth factor in breast cancer in vitro and in vivo: the role of estrogen receptor alpha and c-Myc.

31 March 2020

1 reference

Myc regulates embryonic vascular permeability and remodeling.

31 March 2020

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Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation

31 March 2020

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myc function and regulation

31 March 2020

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c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

31 March 2020

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c-MYC: more than just a matter of life and death

31 March 2020

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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

31 March 2020

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Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

31 March 2020

1 reference

Mechanisms of tamoxifen-induced apoptosis

31 March 2020

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Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer

31 March 2020

1 reference

31 March 2020

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Modelling Myc inhibition as a cancer therapy

31 March 2020

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Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance

31 March 2020

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Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

31 March 2020

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Topological domain structure of the Escherichia coli chromosome

31 March 2020

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DNA supercoiling - a global transcriptional regulator for enterobacterial growth?

31 March 2020

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Large-scale effects of transcriptional DNA supercoiling in vivo

31 March 2020

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Transcriptionally driven cruciform formation in vivo

31 March 2020

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Rapid spontaneous accessibility of nucleosomal DNA.

31 March 2020

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Structural plasticity of single chromatin fibers revealed by torsional manipulation

31 March 2020

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Bidirectional gene organization: a common architectural feature of the human genome.

31 March 2020

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An abundance of bidirectional promoters in the human genome

31 March 2020

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DNA topoisomerases: structure, function, and mechanism

31 March 2020

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Differential control of transcription-induced and overall DNA supercoiling by eukaryotic topoisomerases in vitro.

31 March 2020

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Measurement of unrestrained negative supercoiling and topological domain size in living human cells

31 March 2020

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The functional response of upstream DNA to dynamic supercoiling in vivo

31 March 2020

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Targeted melting and binding of a DNA regulatory element by a transactivator of c-myc

31 March 2020

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The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression

31 March 2020

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Transcription is associated with Z-DNA formation in metabolically active permeabilized mammalian cell nuclei

31 March 2020

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The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression

31 March 2020

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Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum

31 March 2020

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Cellular nucleic acid binding protein regulates the CT element of the human c-myc protooncogene

31 March 2020

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Molecular basis of sequence-specific single-stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single-stranded DNA

31 March 2020

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Structure and dynamics of KH domains from FBP bound to single-stranded DNA

31 March 2020

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hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation

31 March 2020

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DNA tetraplex formation in the control region of c-myc

31 March 2020

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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

31 March 2020

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The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4

31 March 2020

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Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter

31 March 2020

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Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization

31 March 2020

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Tetraplex DNA transitions within the human c-myc promoter detected by multivariate curve resolution of fluorescence resonance energy transfer

31 March 2020

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Biophysical studies of the c-MYC NHE III1 promoter: model quadruplex interactions with a cationic porphyrin

31 March 2020

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The i-motif in nucleic acids

31 March 2020

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A nuclease hypersensitive element in the human c-myc promoter adopts several distinct i-tetraplex structures

31 March 2020

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A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes

31 March 2020

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Loop-length-dependent folding of G-quadruplexes

31 March 2020

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Influence of loop size on the stability of intramolecular DNA quadruplexes

31 March 2020

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NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1

31 March 2020

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Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression

31 March 2020

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Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein

31 March 2020

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Novel molecular mechanism for actinomycin D activity as an oncogenic promoter G-quadruplex binder

31 March 2020

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Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives

31 March 2020

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NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells

31 March 2020

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Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb)

31 March 2020

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Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter

31 March 2020

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Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene

31 March 2020

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Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4

31 March 2020

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Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands

31 March 2020

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Prevalence of quadruplexes in the human genome

31 March 2020

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G-quadruplexes in promoters throughout the human genome

31 March 2020

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Genome-wide computational and expression analyses reveal G-quadruplex DNA motifs as conserved cis-regulatory elements in human and related species.

31 March 2020

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Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells.

31 March 2020

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Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation

31 March 2020

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DNA and associated targets for drug design

31 March 2020

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The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer

31 March 2020

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Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

31 March 2020

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DNA torsional stress propagates through chromatin fiber and participates in transcriptional regulation

31 March 2020

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G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo

31 March 2020

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Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter

31 March 2020

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Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter

31 March 2020

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Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins

31 March 2020

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Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription

31 March 2020

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Protein hnRNPA1 binds to a critical G-rich element of KRAS and unwinds G-quadruplex structures: implications in transcription

31 March 2020

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MYC oncogenes and human neoplastic disease

31 March 2020

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Myc pathways provoking cell suicide and cancer

31 March 2020

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The myc oncogene: MarvelouslY Complex

31 March 2020

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31 March 2020

The many faces of c-MYC.

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Reversible tumorigenesis by MYC in hematopoietic lineages

31 March 2020

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Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations

31 March 2020

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Sustained loss of a neoplastic phenotype by brief inactivation of MYC

31 March 2020

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Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis

31 March 2020

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MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

31 March 2020

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Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation

31 March 2020

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The FBP interacting repressor targets TFIIH to inhibit activated transcription

31 March 2020

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Loss of FBP function arrests cellular proliferation and extinguishes c-myc expression

31 March 2020

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Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization

31 March 2020

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8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas

31 March 2020

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Overexpression of cyclin D1 and c-Myc gene products in human primary epithelial ovarian cancer

31 March 2020

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c-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: incidence, mechanisms, and clinical significance

31 March 2020

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Comparative immunohistochemical analysis of pediatric Burkitt lymphoma and diffuse large B-cell lymphoma

31 March 2020

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Transformation of follicular lymphoma to diffuse large B-cell lymphoma proceeds by distinct oncogenic mechanisms

31 March 2020

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Abnormal expression of apoptosis-related genes in haematological malignancies: overexpression of MYC is poor prognostic sign in mantle cell lymphoma.

31 March 2020

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A far upstream element stimulates c-myc expression in undifferentiated leukemia cells

31 March 2020

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12 December 2020

Mechanisms of transcriptional repression by Myc.

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12 December 2020

Metabolism of c-myc gene products: c-myc mRNA and protein expression in the cell cycle

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12 December 2020

Function of the c-Myc oncoprotein

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12 December 2020

c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo.

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12 December 2020

Genomic effects of tamoxifen.

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12 December 2020

Supercoil-driven DNA structures regulate genetic transactions

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12 December 2020

C-myc and the yeast transcription factor PHO4 share a common CACGTG-binding motif

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12 December 2020

Quartets in G-major. The First International Meeting on Quadruplex DNA.

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12 December 2020

Altered gene expression and oncogenesis of B-cell neoplasia

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12 December 2020

Control of c-myc regulation in normal and neoplastic cells.

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12 December 2020

Contributions of Myc to tumorigenesis

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12 December 2020

Identifiers

DOI

10.1038/NRC2733

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Dimensions Publication ID

21 August 2017

1025071837

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