Executioners of apoptosis in pancreatic {beta}-cells: not just for cell death (Q37661239)

21 August 2017

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title

Executioners of apoptosis in pancreatic {beta}-cells: not just for cell death (English)

1 reference

21 August 2017

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Diana Choi

1

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PubMed ID

20028968

21 August 2017

Minna Woo

series ordinal

2

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21 August 2017

22 December 2009

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American Journal of Physiology - Endocrinology and Metabolism

21 August 2017

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21 August 2017

298

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21 August 2017

E735-41

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21 August 2017

4

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Human ICE/CED-3 protease nomenclature

21 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Inhibition of Bax channel-forming activity by Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Life and death of the pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspase-3 has a nonapoptotic function in erythroid maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Molecular cloning of the interleukin-1 beta converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Deletion of Fas in the pancreatic beta-cells leads to enhanced insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspases: the executioners of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

XIAP overexpression in islet beta-cells enhances engraftment and minimizes hypoxia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspase 3 activity is required for skeletal muscle differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Endoplasmic reticulum stress and the development of diabetes: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Sequential activation of caspases and synergistic beta-cell cytotoxicity by palmitate and anti-Fas antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Transmembrane TNF and IFNgamma induce caspase-independent death of primary mouse pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

The caspase inhibitor z-VAD is more effective than CD18 adhesion blockade in reducing muscle ischemia-reperfusion injury: implication for clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Programmed cell death in animal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspase-3-mediated cleavage of the NF-kappa B subunit p65 at the NH2 terminus potentiates naphthoquinone analog-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspase-8 serves both apoptotic and nonapoptotic roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspase function in programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Beta-cell apoptosis in the pathogenesis of human type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

The pancreatic beta-cell in human Type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

beta-Cell death during progression to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Nobel Prize in Physiology or Medicine. Tiny worm takes a star turn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Short-term culture with the caspase inhibitor z-VAD.fmk reduces beta cell apoptosis in transplanted islets and improves the metabolic outcome of the graft

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Autoimmune type 1 diabetes: resolved and unresolved issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Mitochondria: regulating the inevitable.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Type 2 diabetes-a matter of beta-cell life and death?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

IAP proteins: blocking the road to death's door

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

The role of c-FLIP in modulation of CD95-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

The Fas pathway is involved in pancreatic beta cell secretory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Potentiation of neuroblastoma metastasis by loss of caspase-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Active caspase-3 is required for osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Apoptosis in the pathogenesis and treatment of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspase-10 is an initiator caspase in death receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Essential role of caspase-3 in apoptosis of mouse beta-cells transfected with human Fas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Autophagic programmed cell death by selective catalase degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00696.2009

10.1152/AJPENDO.00696.2009

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

20028968