The IL-1 family: regulators of immunity (Q37676929)

21 August 2017

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title

The IL-1 family: regulators of immunity (English)

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21 August 2017

John E Sims

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author name string

Dirk E Smith

series ordinal

2

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21 August 2017

18 January 2010

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Nature Reviews Immunology

21 August 2017

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21 August 2017

10

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21 August 2017

89-102

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21 August 2017

2

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Interleukin-1-receptor antagonist in type 2 diabetes mellitus

21 August 2017

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Immunological and inflammatory functions of the interleukin-1 family

31 March 2020

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The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

31 March 2020

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The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases

31 March 2020

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A new nomenclature for IL-1-family genes

31 March 2020

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Genomic organization of the interleukin-1 locus

31 March 2020

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A sequence-based map of the nine genes of the human interleukin-1 cluster

31 March 2020

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The inflammasomes: guardians of the body

31 March 2020

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Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

31 March 2020

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Interleukin-33 is biologically active independently of caspase-1 cleavage

31 March 2020

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Identification of a membrane-associated interleukin 1 in macrophages

31 March 2020

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Transcriptional and translational regulation of IL-1 alpha and IL-1 beta account for the control of IL-1 in experimental yersiniosis

31 March 2020

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Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion

31 March 2020

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IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity

31 March 2020

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IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response

31 March 2020

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Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes.

31 March 2020

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The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription

31 March 2020

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Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex

31 March 2020

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Interleukin-1 receptor antagonist: role in biology

31 March 2020

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Type I IL-1 receptor mediates IL-1 and intracellular IL-1 receptor antagonist effects in skin inflammation

31 March 2020

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Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4

31 March 2020

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The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action

31 March 2020

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Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme

31 March 2020

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IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

31 March 2020

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Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules

31 March 2020

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Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket

31 March 2020

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The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

31 March 2020

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Mature interleukin-33 is produced by calpain-mediated cleavage in vivo

31 March 2020

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The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33.

31 March 2020

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Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs

31 March 2020

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Annotating genes with potential roles in the immune system: six new members of the IL-1 family

31 March 2020

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Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2

31 March 2020

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High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity

31 March 2020

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Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production

31 March 2020

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IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp

31 March 2020

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A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity

31 March 2020

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The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines

31 March 2020

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Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity

31 March 2020

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Cloning and characterization of IL-1HY2, a novel interleukin-1 family member

31 March 2020

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SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

31 March 2020

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Lack of Toll IL-1R8 Exacerbates Th17 Cell Responses in Fungal Infection

31 March 2020

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TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization

31 March 2020

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Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils

31 March 2020

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Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

31 March 2020

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T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses

31 March 2020

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T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis

31 March 2020

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Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system

31 March 2020

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Cutting edge: The ST2 ligand IL-33 potently activates and drives maturation of human mast cells

31 March 2020

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The cytokine interleukin-33 mediates anaphylactic shock

31 March 2020

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Basophils trump dendritic cells as APCs for T(H)2 responses

31 March 2020

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Roles of IL-18 in basophils and mast cells

31 March 2020

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IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production

31 March 2020

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IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

31 March 2020

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An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor

31 March 2020

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Cutting edge: Priming of NK cells by IL-18.

31 March 2020

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IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells.

31 March 2020

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The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.

31 March 2020

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IL-18 time-dependently modulates Th1/Th2 cytokine production by ligand-activated NKT cells

31 March 2020

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Critical regulation of early Th17 cell differentiation by interleukin-1 signaling

31 March 2020

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Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression

31 March 2020

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IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

31 March 2020

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IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

31 March 2020

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IL-18 together with anti-CD3 antibody induces human Th1 cells to produce Th1- and Th2-cytokines and IL-8.

31 March 2020

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IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

31 March 2020

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Role of interleukin 1 in the activation of T lymphocytes

31 March 2020

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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

31 March 2020

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Development, cytokine profile and function of human interleukin 17-producing helper T cells

31 March 2020

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A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.

31 March 2020

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IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease

31 March 2020

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ATP drives lamina propria T(H)17 cell differentiation

31 March 2020

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A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses

31 March 2020

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The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4

31 March 2020

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Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

31 March 2020

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IL-17-producing human peripheral regulatory T cells retain suppressive function

31 March 2020

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Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1

31 March 2020

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The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT

31 March 2020

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Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

31 March 2020

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Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells

31 March 2020

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Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen

31 March 2020

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IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells

31 March 2020

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The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model

31 March 2020

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Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells.

31 March 2020

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IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

31 March 2020

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Anakinra for rheumatoid arthritis: a systematic review

31 March 2020

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Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

31 March 2020

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The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis

31 March 2020

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Gout-associated uric acid crystals activate the NALP3 inflammasome

31 March 2020

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A pilot study of IL-1 inhibition by anakinra in acute gout

31 March 2020

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Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis

31 March 2020

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IL-33 exacerbates antigen-induced arthritis by activating mast cells

31 March 2020

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TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.

31 March 2020

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Early molecular events in the induction phase of contact sensitivity

31 March 2020

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Langerhans cells are the major source of mRNA for IL-1 beta and MIP-1 alpha among unstimulated mouse epidermal cells

31 March 2020

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Interleukin (IL)-18 induces Langerhans cell migration by a tumour necrosis factor-alpha- and IL-1beta-dependent mechanism

31 March 2020

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Contribution of Langerhans cell-derived IL-18 to contact hypersensitivity

31 March 2020

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Interleukin-1 but not tumour necrosis factor alpha synergistically upregulates the granulocyte-macrophage colony-stimulating factor-induced B7-1 expression of murine Langerhans cells

31 March 2020

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Interleukin-1 beta and granulocyte-macrophage colony-stimulating factor mediate Langerhans cell maturation differently

31 March 2020

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Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone.

31 March 2020

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IL-18 binding protein protects against contact hypersensitivity

31 March 2020

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Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity

31 March 2020

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Pathogenesis and therapy of psoriasis

31 March 2020

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Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene.

31 March 2020

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Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array

31 March 2020

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Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation

31 March 2020

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Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers -- IL-12, IL-18 and IL-23

31 March 2020

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TNF Inhibition Rapidly Down-Regulates Multiple Proinflammatory Pathways in Psoriasis Plaques

31 March 2020

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Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis

31 March 2020

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Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice

31 March 2020

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Exacerbated and prolonged allergic and non-allergic inflammatory cutaneous reaction in mice with targeted interleukin-18 expression in the skin

31 March 2020

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IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions

31 March 2020

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Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis

31 March 2020

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IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis

31 March 2020

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Circulating serum levels of IL-1ra in patients with relapsing remitting multiple sclerosis are normal during remission phases but significantly increased either during exacerbations or in response to IFN-beta treatment

31 March 2020

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Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1beta in human monocytes and multiple sclerosis.

31 March 2020

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IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells

31 March 2020

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Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation

31 March 2020

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IL-18 activity in systemic lupus erythematosus

31 March 2020

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High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein

31 March 2020

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Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma.

31 March 2020

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IL-18 might reflect disease activity in mild and moderate asthma exacerbation

31 March 2020

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Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse

31 March 2020

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Interleukin-18-deficient mice exhibit diminished chronic inflammation and airway remodelling in ovalbumin-induced asthma model

31 March 2020

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Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation

31 March 2020

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Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology

31 March 2020

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Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway

31 March 2020

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Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

31 March 2020

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Crohn's disease: innate immunodeficiency?

31 March 2020

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Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease

31 March 2020

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IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-gamma dependent manner

31 March 2020

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Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice

31 March 2020

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Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL-2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes.

31 March 2020

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Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice

31 March 2020

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Purification and biochemical characterization of an invertebrate interleukin 1

31 March 2020

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Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)

31 March 2020

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

31 March 2020

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De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

31 March 2020

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Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition

31 March 2020

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Use of canakinumab in the cryopyrin-associated periodic syndrome

31 March 2020

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Interleukin-1-receptor antagonist in the Muckle-Wells syndrome.

31 March 2020

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Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies

31 March 2020

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An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

31 March 2020

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An autoinflammatory disease due to homozygous deletion of the IL1RN locus

31 March 2020

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Anakinra for flares of pyogenic arthritis in PAPA syndrome

31 March 2020

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Resistant Behçet disease responsive to anakinra

31 March 2020

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Treatment with anakinra in the hyperimmunoglobulinemia D/periodic fever syndrome

31 March 2020

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The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever

31 March 2020

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Persistent efficacy of anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome

31 March 2020

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Beneficial response to anakinra and thalidomide in Schnitzler's syndrome

31 March 2020

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Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease?

31 March 2020

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Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

31 March 2020

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Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent

31 March 2020

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Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures

31 March 2020

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Interleukin-1 and inflammatory neurodegeneration

31 March 2020

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Interleukin-1 receptor antagonist attenuates the severity of spinal cord ischemic injury in rabbits

31 March 2020

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Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling.

31 March 2020

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Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice.

31 March 2020

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Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra

31 March 2020

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A functional interleukin-1 receptor antagonist polymorphism influences atherosclerosis development. The interleukin-1beta:interleukin-1 receptor antagonist balance in atherosclerosis

31 March 2020

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Increased plasma concentrations of interleukin-18 in acute coronary syndromes.

31 March 2020

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Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina

31 March 2020

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Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding

31 March 2020

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IL-18 Accelerates Atherosclerosis Accompanied by Elevation of IFN-γ and CXCL16 Expression Independently of T Cells

31 March 2020

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Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice

31 March 2020

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Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death

31 March 2020

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Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study).

31 March 2020

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Recombinant human IL-1 alpha and -1 beta potentiate IgE-mediated histamine release from human basophils

31 March 2020

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12 December 2020

Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR.

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12 December 2020

Cytokine receptors and B cell functions. I. Recombinant soluble receptors specifically inhibit IL-1- and IL-4-induced B cell activities in vitro

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12 December 2020

Expression and function of OX40 ligand on human dendritic cells

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12 December 2020

Regulation of E-cadherin-mediated adhesion in Langerhans cell-like dendritic cells by inflammatory mediators that mobilize Langerhans cells in vivo

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12 December 2020

Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation

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12 December 2020

Imbalance of interleukin 18 and interleukin 18 binding protein in patients with lupus nephritis

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12 December 2020

An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin

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12 December 2020

Cytokine pattern of Langerhans cells isolated from murine epidermal cell cultures

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12 December 2020

IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.

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12 December 2020

Interleukin-18/Interleukin-18 Binding Protein Signaling Modulates Atherosclerotic Lesion Development and Stability

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12 December 2020

Biologic basis for interleukin-1 in disease

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12 December 2020

Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively

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12 December 2020

IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor.

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12 December 2020

Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritis.

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12 December 2020

IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma

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12 December 2020

Cross-talk between interleukin 1beta (IL-1beta) and IL-6 signalling pathways: IL-1beta selectively inhibits IL-6-activated signal transducer and activator of transcription factor 1 (STAT1) by a proteasome-dependent mechanism

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12 December 2020

NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype.

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12 December 2020

Identifiers

DOI

10.1038/NRI2691

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21 August 2017

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PubMed ID

20081871